Functional imaging in radiation therapy planning for head and neck cancer

Treatment delays in completing radiotherapy (RT) for many neoplasms are a major problem affecting treatment outcome, as increasingly shown in the literature. Overall treatment time (OTT) could be a critical predictor of local tumor control and/or survival. In an attempt to establish a protocol for managing delays during RT, especially for heavily overloaded units, we have extensively reviewed the available literature on head and neck cancer. We confirmed a large deleterious effect of prolonged OTT on both local control and survival of these patients.

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“…78,79 It is of vital importance to prevent, if possible, any part of that gain from being lost by OTT delays.…”

Section: Discussionmentioning

confidence: 99%

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Ferreira¹,

Olásolo²,

Azinovic³

et al. 2015

Reports of Practical Oncology & Radiotherapy

113

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“…The use of advanced pretreatment imaging is increasing in radiotherapy (RT). Magnetic resonance imaging (MRI) and positron emission tomography (PET) are today widely used for target definition for several common indications for radiotherapy, for example, prostate cancer, lung cancer, intracranial malignances, and head and neck cancer . Potential novel applications include quantitative PET and MR imaging to facilitate dose painting by numbers, objective or automatic identification of target volumes, or stratification of patients to different treatment regimens …”

Section: Introductionmentioning

confidence: 99%

Technical Note: Adapting a GE SIGNA PET/MR scanner for radiotherapy

et al. 2018

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“…The interobserver contouring uncertainties of organs with electron density similar to organs at risk in human body were measured using KVCT and MVCT. 18,19 Additionally, the subjective image quality for perception and delineation of structures was assessed. This paper provides an opportunity to explore differences of contouring structures with different densities in a water phantom.…”

Section: Discussionmentioning

confidence: 99%

Influence of the type of imaging on the delineation process during the treatment planning

Jackowiak

Bąk

Kowalik

et al. 2015

Reports of Practical Oncology & Radiotherapy

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a b s t r a c tAim: The aim of this study was to compare the intra-and interobserver contouring variability for structures with density of organ at risk in two types of tomography: kilovoltage computed tomography (KVCT) versus megavoltage computed tomography (MVCT). The intraand interobserver differences were examined on both types of tomography for structures which simulate human tissue or organs. Materials and methods:Six structures with density of the liver, bone, trachea, lung, soft tissue and muscle were created and used. For the measurements, the special water phantom with all structures was designed. To evaluate interobserver variability, five observers delineated the structures in both types of computed tomography (CT).Results: Intraobserver variability was in the range of 1-14% and was the largest for the liver. (51.86 vs. 67.97), the volume on MVCT was smaller than KVCT. The statistically significant differences between observers were observed for structures with density of the liver, bone and soft tissue on KVCT and for the liver, lung and soft tissue on MVCT. For the structures with density of the trachea and muscles, there were no significant differences for both types of tomography.Conclusions: During the contouring process the interobserver and intraobserver contouring uncertainty was larger on MVCT, especially for structures with HU near 80, compared with KVCT.

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Functional imaging in radiation therapy planning for head and neck cancer

Cited by 11 publications

References 70 publications

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature

Technical Note: Adapting a GE SIGNA PET/MR scanner for radiotherapy

Influence of the type of imaging on the delineation process during the treatment planning

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