Functional Genetic Variants of PPAR&amp;#947; and PPARα Encoding Peroxisome Proliferator-Activated Receptors and Susceptibility to Ischemic Stroke in Chinese Han Population

Tong, Yeqing; Cai, Li; Han, Shirong; Lü, Qing; Guan, Xiaohong; Ying, Xiaoxv; Hou, Shuangyi; Zhan, Fanxian; Cheng, Jinquan; Liu, Jiafa

doi:10.1159/000442306

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…CYP2C19 gene polymorphisms are associated with long-term recurrent risk of ischemic stroke [45]. Peroxisome proliferator-activated receptors could be a protective factor for ischemic stroke in the Chinese Han population [46]. A previous study showed that genetic factors are associated with age at stroke onset and sex [47].…”

Section: Discussionmentioning

confidence: 99%

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

2016

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BackgroundIschemic stroke and myocardial infarction are fatal diseases and are among the top 10 causes of death in Korea, including arterial thromboembolic events. Many previous studies have described the function of interleukin-6 (IL-6) in arterial thromboembolic events and the association between promoter single-nucleotide polymorphism (SNP) (rs1800795; −174, G/C) of the IL-6 gene. However, these results were controversial. Therefore, we performed a meta-analysis to more precisely assess the association between the SNP of the IL-6 gene and susceptibility to arterial thromboembolic events.Material/MethodsWe used PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases. Comprehensive Meta-analysis software (Corporation, NJ) was used to evaluate the relationship between rs1800795 SNP of IL-6 gene and risk of arterial thromboembolic events. Odds ratio (OR), 95% confidence interval (CI), and P value were also calculated. The 13 eligible studies were analyzed in the meta-analysis.ResultsThe present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model).ConclusionsWe found that rs1800795 SNP of IL-6 gene was not related to arterial thromboembolic events. However, further study will be needed to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

2016

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“…Tong et al. (2016) additionally reported a protective effect against IS formation in a Chinese population. In contrast, another study by Wang et al.…”

Section: Discussionmentioning

confidence: 96%

“…Li et al, 2016;Z. J. Liu et al, 2010;Lu et al, 2009;Shen & Ha, 2005;Sun, 2010;Tong et al, 2015Tong et al, , 2016Wang et al, 2019;Wei et al, 2013;Yuan, 2008;Zafarmand et al, 2008). Of these, 10 case-control studies focused on rs1801282 C/G polymorphism (Bazina et al, 2015;L.…”

Section: Study Characteristicsmentioning

confidence: 99%

Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

Cheng

Yang

et al. 2021

Brain and Behavior

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Background: Published researches have suggested some associations between PPARγ and ischemic stroke (IS) development. This meta-analysis was conducted to evaluate the association between PPAR-γ gene polymorphisms and IS risk. Materials and methods:A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR-γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted.Result: Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09-4.35, p = .03, I 2 = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07-4.32, p = .03, I 2 = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk. Conclusion:In conclusion, our study showed that PPAR-γ rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.

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“…The 162Leu/Val genotype is more frequent in the German, Danish, Czech, and Brazilian population, whereas the 162Val/Val is more frequent only in the Tunisian population [47]. It is possible to demonstrate a much stronger association between this polymorphism (V162 allele), than the intron 7 G/C polymorphisms with stage C heart failure.…”

Section: Single Nucleotides Polymorphisms (Snps)mentioning

confidence: 99%

Impact of PPAR-Alpha Polymorphisms—The Case of Metabolic Disorders and Atherosclerosis

Ruscica

Busnelli

Runfola

et al. 2019

IJMS

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Peroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes, from reduced triglyceridemia to improvement in the metabolic syndrome. Polymorphisms of PPARα are of interest in order to improve our understanding of metabolic disorders associated with a raised or reduced risk of diseases. PPARα polymorphisms are mainly characterized by two sequence changes, L162V and V227A, with the latter occurring only in Eastern nations, and by numerous SNPs (Single nucleotide polymorphisms) with a less clear biological role. The minor allele of L162V associates with raised total cholesterol, LDL-C (low-density lipoprotein cholesterol), and triglycerides, reduced HDL-C (high-density lipoprotein metabolism), and elevated lipoprotein (a). An increased cardiovascular risk is not clear, whereas a raised risk of diabetes or of liver steatosis are not well supported. The minor allele of the V227A polymorphism is instead linked to a reduction of steatosis and raised γ-glutamyltranspeptidase levels in non-drinking Orientals, the latter being reduced in drinkers. Lastly, the minor allele of rs4353747 is associated with a raised high-altitude appetite loss. These and other associations indicate the predictive potential of PPARα polymorphisms for an improved understanding of human disease, which also explain variability in the clinical response to specific drug treatments or dietary approaches.

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Functional Genetic Variants of PPARγ and PPARα Encoding Peroxisome Proliferator-Activated Receptors and Susceptibility to Ischemic Stroke in Chinese Han Population

Cited by 5 publications

References 10 publications

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

Impact of PPAR-Alpha Polymorphisms—The Case of Metabolic Disorders and Atherosclerosis

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