Functional Fermented Probiotics, Prebiotics, and Synbiotics from Non‐Dairy Products: A Perspective from Nutraceutical

Kumar, Dharmendra; Lal, Milan Kumar; Dutt, Som; Raigond, Pinky; Changan, Sushil; Tiwari, Rahul Kumar; Chourasia, Kumar Nishant; Mangal, Vikas

doi:10.1002/mnfr.202101059

Cited by 33 publications

(12 citation statements)

References 96 publications

(94 reference statements)

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“…Recent studies have found that probiotics not only regulate intestinal microbial balance ( Li et al, 2018 ; Kumar et al, 2022 ), but are also relevant to diseases that are harmful to human health, such as inflammation ( Yilmaz et al, 2022 ), tumors ( Mohd et al, 2022 ), and leukemia ( Fric, 2007 ). The micro-ecological imbalance of intestinal flora should not be ignored.…”

Section: Discussionmentioning

confidence: 99%

Composition analysis and prebiotics properties of polysaccharides extracted from Lepista sordida submerged cultivation mycelium

et al. 2023

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In this paper, Lepista sordida polysaccharides (LSP) were separated from Lepista sordida (L. sordida) mainly using the Ultrasonic-Micro Wave Synergy Extraction (UMSE) method and purified by graded alcohol precipitation. Three polysaccharide components: 40%-LSP-UMSE, 60%-LSP-UMSE, and 80%-LSP-UMSE were obtained and further analyzed the physicochemical properties, structural characteristics, and antioxidant activity. And the effects on the proliferation of Lactobacillus casei of three polysaccharide components were studied. The characteristic absorption peaks and the β-glycosidic bond of three polysaccharide components were the direct expression at UV 200 nm using UV and FT-IR spectroscopy. The three polysaccharide components were mainly composed of glucose, mannose, galactose, and ribose using high-performance liquid chromatography (HPLC) analysis. The antioxidant activity study revealed that the polysaccharides obtained by the UMSE method had better antioxidant activity compared to the traditional “Hot Water Extraction (HWE)” method. In addition, the polysaccharide components promoted the proliferation of L. casei to some extent. 40%-LSP-UMSE, 80%-LSP-UMSE as the carbon source had better acid production than the control inulin. Three LSP-UMSE used as a carbon source compared with glucose for culturing L. casei could significantly improve its tolerance to bile salts. Results are helpful to develop the bioactive polysaccharides from Lepista sordida and beneficial to develop a unique health and functional product in the future.

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Section: Discussionmentioning

confidence: 99%

Composition analysis and prebiotics properties of polysaccharides extracted from Lepista sordida submerged cultivation mycelium

et al. 2023

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“…Therefore, the shelf life of probiotics cannot be accurately predicted. As a result, the industry has to struggle alot to substantiate the label’s claims[ 94 ].…”

Section: Obstacles Challenges and Future Prospectsmentioning

confidence: 99%

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

Roy¹,

Dhaneshwar²

2023

World J Gastroenterol

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Experimental evidence supports the fact that changes in the bowel microflora due to environmental or dietary factors have been investigated as implicating factors in the etiopathogenesis of inflammatory bowel disease (IBD). The amassing knowledge that the inhabited microbiome regulates the gut physiology and immune functions in IBD, has led researchers to explore the effectiveness of prebiotics, probiotics, and synbiotics in treating IBD. This therapeutic approach focuses on restoring the dynamic balance between the microflora and host defense mechanisms in the intestinal mucosa to prevent the onset and persistence of intestinal inflammation. Numerous microbial strains and carbohydrate blends, along with their combinations have been examined in experimental colitis models and clinical trials, and the results indicated that it can be an attractive therapeutic strategy for the suppression of inflammation, remission induction, and relapse prevention in IBD with minimal side effects. Several mechanisms of action of probiotics (for e.g., Lactobacillus species, and Bifidobacterium species) have been reported such as suppression of pathogen growth by releasing certain antimicrobial mediators (lactic and hydrogen peroxide, acetic acid, and bacteriocins), immunomodulation and initiation of an immune response, enhancement of barrier activity, and suppression of human T-cell proliferation. Prebiotics such as lactulose, lactosucrose, oligofructose, and inulin have been found to induce the growth of certain types of host microflora, resulting in an enriched enteric function. These non-digestible food dietary components have been reported to exert anti-inflammatory effects by inhibiting the expression of tumor necrosis factor-α-related cytokines while augmenting interleukin-10 levels. Although pro-and prebiotics has established their efficacy in healthy subjects, a better understanding of the luminal ecosystem is required to determine which specific bacterial strain or combination of probiotics and prebiotics would prove to be the ideal treatment for IBD. Clinical trials, however, have given some conflicting results, requiring the necessity to cite the more profound clinical effect of these treatments on IBD remission and prevention. The purpose of this review article is to provide the most comprehensive and updated review on the utility of prebiotics, probiotics, and synbiotics in the management of active Crohn’s disease and ulcerative colitis/pouchitis.

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“…The intestinal microbiota plays a vital role in human physiology through the production of metabolites that regulate essential activities that facilitate a symbiotic relationship between the microbes and the host. Polysaccharides are key regulators of colon physiology and the changing intestinal environment [ 101 ], and they are selectively used by gut microbiota to enhance the selection, colonization, and survival of probiotic bacteria acting as prebiotics [ 102 ].…”

Section: Human Studies Examining Polysaccharide Modulation Of Gut Mic...mentioning

confidence: 99%

Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health

Álvarez‐Mercado

Plaza‐Díaz

2022

Nutrients

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A polysaccharide is a macromolecule composed of more than ten monosaccharides with a wide distribution and high structural diversity and complexity in nature. Certain polysaccharides are immunomodulators and play key roles in the regulation of immune responses during the progression of some diseases. In addition to stimulating the growth of certain intestinal bacteria, polysaccharides may also promote health benefits by modulating the gut microbiota. In the last years, studies about the triad gut microbiota–polysaccharides–health have increased exponentially. In consequence, in the present review, we aim to summarize recent knowledge about the function of dietary polysaccharides on gut microbiota composition and how these effects affect host health.

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Functional Fermented Probiotics, Prebiotics, and Synbiotics from Non‐Dairy Products: A Perspective from Nutraceutical

Cited by 33 publications

References 96 publications

Composition analysis and prebiotics properties of polysaccharides extracted from Lepista sordida submerged cultivation mycelium

Composition analysis and prebiotics properties of polysaccharides extracted from Lepista sordida submerged cultivation mycelium

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health

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