2021
DOI: 10.3390/ijms22063177
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Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells

Abstract: TRPV1, known as a capsaicin receptor, is the best-described transient receptor potential (TRP) ion channel. Recently, it was shown to be expressed by non-excitable cells such as lymphocytes. However, the data regarding the functional expression of the TRPV1 channel in the immune cells are often contradictory. In the present study, we performed a phylogenetical analysis of the canine TRP ion channels, we assessed the expression of TRPV1 in the canine peripheral blood mononuclear cells (PBMC) by qPCR and Western… Show more

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Cited by 4 publications
(1 citation statement)
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“…Macrophages of the skin of the AD-dogs showed GPR55-IR, a finding consistent with those obtained in the macrophages of rodents, humans ( 101 , 102 ) and dogs ( 43 ). Macrophages of the skin of the AD-dogs also expressed TRPV1-IR; this finding supported a recent study which showed the expression of TRPV1 on both the mRNA and the protein levels in canine peripheral blood mononuclear cells and indicated that this ion channel was functional ( 103 ). In addition, there is a study on mice supporting the role of the TRPV1 channel in macrophage activation and the effectiveness of a subset of TRPV1 channel antagonists in suppressing inflammatory responses ( 104 ).…”
Section: Discussionsupporting
confidence: 88%
“…Macrophages of the skin of the AD-dogs showed GPR55-IR, a finding consistent with those obtained in the macrophages of rodents, humans ( 101 , 102 ) and dogs ( 43 ). Macrophages of the skin of the AD-dogs also expressed TRPV1-IR; this finding supported a recent study which showed the expression of TRPV1 on both the mRNA and the protein levels in canine peripheral blood mononuclear cells and indicated that this ion channel was functional ( 103 ). In addition, there is a study on mice supporting the role of the TRPV1 channel in macrophage activation and the effectiveness of a subset of TRPV1 channel antagonists in suppressing inflammatory responses ( 104 ).…”
Section: Discussionsupporting
confidence: 88%