Functional Electrospun Fibers for Local Therapy of Cancer

Zhao, Jingwen; Cui, Wenguo

doi:10.1007/s42765-020-00053-9

Cited by 117 publications

(66 citation statements)

References 115 publications

(133 reference statements)

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“…The structural characteristics of SMPFs make it suitable for the delivery and release of different drugs. It can simulate the extracellular matrix used in tissue engineering and provide more opportunities for fixing functional groups in medical diagnosis and other applications [99,100]. Furthermore, the research on SMPFs in other areas has also attracted wide attention, including energy harvesting and stress sensors.…”

Section: Applications Of Shape Memory Polymer Fibersmentioning

confidence: 99%

Shape Memory Polymer Fibers: Materials, Structures, and Applications

et al. 2021

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Shape memory polymer (SMP) is a kind of material that can sense and respond to the changes of the external environment, and its behavior is similar to the intelligent reflection of life. Electrospinning, as a versatile and feasible technique, has been used to prepare shape memory polymer fibers (SMPFs) and expand their structures. SMPFs show some advanced features and functions in many fields. In this review, we give a comprehensive overview of SMPFs, including materials, fabrication methods, structures, multifunction, and applications. Firstly, the mechanism and characteristics of SMP are introduced. We then discuss the electrospinning method to form various microstructures, like non-woven fibers, core/shell fibers, hollow fibers and oriented fibers. Afterward, the multiple functions of SMPFs are discussed, such as multi-shape memory effect, reversible shape memory effect and remote actuation of composites. We also focus on some typical applications of SMPFs, including biomedical scaffolds, drug carriers, self-healing, smart textiles and sensors, as well as energy harvesting devices. At the end, the challenges and future development directions of SMPFs are proposed.

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Section: Applications Of Shape Memory Polymer Fibersmentioning

confidence: 99%

Shape Memory Polymer Fibers: Materials, Structures, and Applications

et al. 2021

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“…As mentioned before, electrospinning can produce fibers from nanoscale to microscale continuously [ [50] , [51] , [52] ]. Scaffolds produced by electrospinning with porous 3D network structure and excellent pore interconnection [ 53 , 54 ], which will facilitate the migration of cells into the electrospinning scaffold and the transportation of nutrients.…”

Section: Fabrication Techniques To Control Various Geometries Of Polyester/ha Compositesmentioning

confidence: 99%

An overview of polyester/hydroxyapatite composites for bone tissue repairing

Cui

Zhao

et al. 2021

Journal of Orthopaedic Translation

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Objectives The polyester/hydroxyapatite (polyester/HA) composites play an important role in bone tissue repairing, mostly because they mimic the composition and structure of naturally mineralized bone tissue. This review aimed to discuss commonly used geometries of polyester/HA composites, including microspheres, membranes, scaffolds and bulks, and their applications in bone tissue repairing and to discuss existed restrictions and developing trends of polyester/HA. Methods The current review was conducted by searching Web of Science, and Google Scholar for relevant studies published related with polyester/HA composites. Selected studies were analyzed with a focus on the fabrication techniques, properties (mechanical properties, biodegradable properties and biological properties) and applications of polyester/HA composites in bone repairing. Results A total of 111 articles were introduced to discuss the review. Different geometries of polyester/HA composites were discussed. In addition, properties and applications of polyester/HA composites were evaluated. The addition of HA into polyester can adjust the mechanical and biodegradability of composites. Besides, the addition of HA into polyester can improve its osteogenic abilities. The results showed that polyester/HA composites can ideal candidate for bone tissue repairing. Conclusion Polyester/HA composites have many remarkable properties, such as appropriate mechanical strength, biodegradability, favorable biological properties. Diverse geometries of polyester/HA composites have been used in bone repairing, drug delivery and implant fixation. Further work needs to be done to investigate existed restrictions, including the controlled degradation rate, controlled drug release performance, well-matched mechanical properties, and novel fabrication techniques. The translational potential of this article The present review reveals the current state of the polyester/HA composites used in bone tissue repairing, contributing to future trends of polyester/HA composites in the forthcoming future.

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“…[ 1 ] With the continuous advances in nanotechnology, a wide variety of nanomaterials possessing remarkable biocompatibility, targeting specificity, prolonged blood circulation time, and enhanced tumor penetration ability have exhibited great potentials in the area of biomedicine. [ 2 ] Although different nanomaterials including but not limited to nanogels, [ 3 ] micelles, [ 4 ] mesoporous silica, [ 5 ] carbon nanotubes, [ 6 ] nanofibers, [ 7 ] carbon dots (CDs), [ 8 ] and dendrimers [ 9 ] have been developed for sensing, bioimaging, or drug delivery applications, hybrid nanoparticles (NPs) that can integrate both diagnostic and therapeutic components are necessary to be developed for precision medicine purposes. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

Guo

Shen

Shi

2021

Macromolecular Bioscience

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Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.

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Functional Electrospun Fibers for Local Therapy of Cancer

Cited by 117 publications

References 115 publications

Shape Memory Polymer Fibers: Materials, Structures, and Applications

Shape Memory Polymer Fibers: Materials, Structures, and Applications

An overview of polyester/hydroxyapatite composites for bone tissue repairing

Construction of Poly(amidoamine) Dendrimer/Carbon Dot Nanohybrids for Biomedical Applications

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