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Introduction. The high prevalence of functional dyspepsia in the population requires detailing the mechanisms of its development with the definition of the role of hormones of the gastrointestinal tract in the development of clinical symptoms.Purpose of the study: to clarify the pathogenetic role of cholecystokinin in functional dyspepsia.Materials and methods. A prospective examination of 90 people aged 22.3 ± 0.17 years, divided into 3 groups, was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. The participants of the study were questioned according to the GSRS questionnaire, their anthropometric data, the concentration of cholecystokinin in the blood before and after the drinking test were determined. Statistical processing included calculation of means, their errors, Mann-Whitney U-test for independent samples and Wilcoxon W-test for related samples, Spearman’s rank correlation test.Results. Patients with EPS are characterized by a statistically significantly greater severity of abdominal pain syndrome (4.33 ± 0.51 points) than those suffering from PDS (2.47 ± 0.38 points) and healthy people (2.19 ± 0.22 points). Dyspeptic syndrome is more typical for patients with PDS (2.07 ± 0.12 points) than those with EPS (1.10 ± 0.04 points). Patients with PDS are characterized by higher values of height, hip volume, lean mass, waist to hip ratio than patients with EPS. The concentration of cholecystokinin in the blood on an empty stomach in patients with EPS (213.37 ± 14.35 pg/ml) is statistically significantly higher than in those examined with PDS (129.45 ± 10.44 pg/ml) and healthy people (146.99 ± 5.17 pg/ml). The level of cholecystokinin in the blood after water exercise in patients with PDS increased statistically significantly to 176.14 ± 8.16 pg/ml, with EPS – decreased to 187.98 ± 7.26 pg/ml. Correlations between the magnitude of cholecystokininemia and the main anthropometric data in EPS and PDS are multidirectional.Conclusion. Cholecystokinin plays an important role in the pathogenesis of gastroduodenal motility disorders in patients with functional dyspepsia.
Introduction. The high prevalence of functional dyspepsia in the population requires detailing the mechanisms of its development with the definition of the role of hormones of the gastrointestinal tract in the development of clinical symptoms.Purpose of the study: to clarify the pathogenetic role of cholecystokinin in functional dyspepsia.Materials and methods. A prospective examination of 90 people aged 22.3 ± 0.17 years, divided into 3 groups, was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. The participants of the study were questioned according to the GSRS questionnaire, their anthropometric data, the concentration of cholecystokinin in the blood before and after the drinking test were determined. Statistical processing included calculation of means, their errors, Mann-Whitney U-test for independent samples and Wilcoxon W-test for related samples, Spearman’s rank correlation test.Results. Patients with EPS are characterized by a statistically significantly greater severity of abdominal pain syndrome (4.33 ± 0.51 points) than those suffering from PDS (2.47 ± 0.38 points) and healthy people (2.19 ± 0.22 points). Dyspeptic syndrome is more typical for patients with PDS (2.07 ± 0.12 points) than those with EPS (1.10 ± 0.04 points). Patients with PDS are characterized by higher values of height, hip volume, lean mass, waist to hip ratio than patients with EPS. The concentration of cholecystokinin in the blood on an empty stomach in patients with EPS (213.37 ± 14.35 pg/ml) is statistically significantly higher than in those examined with PDS (129.45 ± 10.44 pg/ml) and healthy people (146.99 ± 5.17 pg/ml). The level of cholecystokinin in the blood after water exercise in patients with PDS increased statistically significantly to 176.14 ± 8.16 pg/ml, with EPS – decreased to 187.98 ± 7.26 pg/ml. Correlations between the magnitude of cholecystokininemia and the main anthropometric data in EPS and PDS are multidirectional.Conclusion. Cholecystokinin plays an important role in the pathogenesis of gastroduodenal motility disorders in patients with functional dyspepsia.
Objective: to study the mechanism of action of low-mineralized sulfate-chloride-sodium mineral water on the clinical picture and motor function of the stomach in patients with epigastric pain syndrome using the regulatory peptide motilin as an example. Materials and methods: 113 people of both sexes were examined, the average age was 22.3±0.21 years. The observation group (57 people) included individuals with functional dyspepsia in the variant of epigastric pain syndrome, the comparison group included practically healthy individuals (56 people). The questionnaire method was used according to the Gastrointestinal Symptom Rating Scale questionnaire; ELISA method for determining the concentration of motilin in the blood. Mineral water in a volume of 200 ml was taken once by both groups of patients, patients with EPS additionally received a course. Results: in persons with epigastric pain syndrome, abdominal pain prevails. The course intake of mineral water provides a positive clinical trend, confirmed by a decrease in the syndromes of lesions of the upper gastrointestinal tract. A single and course intake of mineral water provides a stable increase in the level of motilin in functional dyspepsia. Conclusion: patients suffering from functional dyspepsia in the variant of epigastric pain syndrome have persistent disorders of motilin secretion compared with healthy individuals. Stimulation of the stomach on a drinking test model showed inadequacy of changes in the level of this hormone. Both a single and a course intake of low-mineralized sulfate-chloride-sodium mineral water contributes to an increase in the concentration of motilin, which should be considered as a physical adaptogenic factor leading to a stable ordering of the body’s functional relationships.
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