Functional distention of the kidney in perinephritic hypertension

The Effect of Partial Clamping of the Renal Artery on Pressures in the Proximal and Distal Tubules and Peritubular Capillaries of the Rat Kidney

“…The present data allow serious doubt to be raised to the general concept of a determinant role of the interstitial pressure to the pressure inside the proximal tubules under normal conditions and would seem quite incompatible with the hypothesis of the kidney as "an inflatable balloon" proposed by Swann (1960Swann ( , 1961. Provided the peritubular or interstitial pressure determines the proximal luminal pressure, it would be expected that the peritubular capillary pressure and hence the proximal intratubular pressure would be significantly lower than normal after clamping the renal artery to such a degree that the filtration pressure is significantly lowered.…”

“…However, any compression of the thin-walled arcuate veins is a most unlikely consequence of a partial arterial obstruction. A venous constriction elicited by angiotensin is not likely either, since it has been demonstrated by Folkow, Johansson and Mellander (1961) that angiotensin is a typical arteriolar or plain muscle cell constrictor with no or insignificant effect on the postarteriolar section of the vascular system, and since the "sinusoidal cushions", described by Swann and co-workers (see Swann 1960), near the junction of the arcuate and interlobular veins almost completely lack smooth muscle cells. A significant pressure drop was found across this effluent constriction, which was thought to maintain the venous pressure peripheral to the constriction equal to or slightly above the interstitial pressure.…”

Renin and angiotensin. A survey of some aspects

“…Both the macula densa (Goormaghtigh, 1937(Goormaghtigh, , 1939Hess and Gross, 1959;Fisher, 1961;Latta, Maunsbach and Cook, 1962;Guyton. 1963;Brown and others, 1964 g;Thurau, 1964;Vander and Miller, 1964) and the afferent glomerular arterioles (Tobian, 1960 a, b;Skinner, McCubbin and Page, 1964;Brown and others, 1964 g) have been considered, as also have more complex functions of renal distensibility (Ogden, 1944;Swann, Railey and Carmignani, 1959;Lowe, 1964).…”