Functional development of the meso- and metanephros

Moritz, Karen M.; Wintour, E. M.

doi:10.1007/s004670050587

Cited by 124 publications

(115 citation statements)

References 41 publications

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“…The mesonephros consists of a small number of relatively large glomeruli but no loops of Henle. Its contribution to renal function is unclear but it may be involved in the production of hypotonic urine, erythropoietin and enzymes of the renin-angiotensin system and nitrogen metabolism in the embryo (Dingemanse & Lamers, 1994 ;Moritz & Wintour, 1999). Cells of the mesonephros also contribute to the testis and adrenal glands (Moritz & Wintour, 1999).…”

Section: mentioning

confidence: 99%

Differences between human and mouse alpha‐fetoprotein expression during early development

et al. 2001

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Alpha-fetoprotein (AFP) is the major serum protein during development. AFP is one of the earliest proteins to be synthesised by the embryonic liver. The synthesis of AFP decreases dramatically after birth and only trace amounts are expressed in the adult liver. The tissue distribution of AFP in early human embryogenesis has not been defined. We have studied the expression pattern of AFP mRNA in human and mouse embryos by in situ hybridisation. In humans, AFP is expressed in the hepatic diverticulum at 26 d postovulation as it differentiates from the foregut endoderm (i.e. in the most primitive hepatocytes). It is also expressed in the endoderm of the gastrointestinal tract and in the yolk sac at this age. AFP is subsequently expressed in the mesonephros and transiently in the developing pancreas. In the mouse, no expression of AFP was observed in the mesonephros but other sites of expression were similar. Thus AFP has a distinct temporospatial expression pattern during the embryonic period and this differs between human and mouse species. It is interesting that AFP is expressed by tumours such as primitive gastrointestinal, renal cell and pancreatic tumours as well as those of hepatocyte origin. This distribution reflects the sites of AFP expression during development.

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Section: mentioning

confidence: 99%

Differences between human and mouse alpha‐fetoprotein expression during early development

et al. 2001

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“…In these species, nephrogenesis continues for a limited period after birth (Moritz & Wintour, 1999), so postnatal ligation in these animals may have some relevance to congenital ureteral obstructions. Even though postnatal models do not reproduce the fetal environment, the delay in renal maturation in rodents versus humans permits relative comparisons of the effects of obstruction on kidney development to be made.…”

Section: Ureteral Ligation/unilateral Ureteral Obstructionmentioning

confidence: 99%

Congenital Obstructive Nephropathy: Clinical Perspectives and Animal Models

Ingraham¹,

McHugh²

2012

Novel Insights on Chronic Kidney Disease, Acute Kidney Injury and Polycystic Kidney Disease

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“…The permanent kidney development start at approximately the 7 th week of gestation with the outgrowth of the ureteric but from caudal end of the mesonephric duct, meeting the metanephric blastema which together will differentiate into nephrons. (Moritz & Wintour, 1999) In addition, integration of small vessel growth is required in nephron formation. The first urine producing nephrons are developed within the first ten weeks of gestation and the amount is increasing with age.…”

Section: Normal Kidney Developmentmentioning

confidence: 99%