Functional Core/Shell Drug Nanoparticles for Highly Effective Synergistic Cancer Therapy

Abstract

Gold (Au)-nanoshelled 10-hydroxycamptothecin nanoparticles (HCPT NPs) are developed with combination of photothermal therapy and chemotherapy for highly effective cancer therapy. The strong near-infrared (NIR) absorbance from Au nanoshells endows the nanocomposites photothermal effects and on-demand drug release. Notably, the drug-loading content reaches up to 63.7 wt%, which is much higher than that in the previously reported nanovehicles systems. Both in vitro and in vivo studies indicate that the combined local specific chemotherapy with external NIR photothermal therapy demonstrates a synergistic effect, which is significantly better than either of them alone. More importantly, due to the high drug-loading content and efficient photothermal effects of the nanocomposites, 100% in vivo tumor elimination is achieved at a low laser irradiation power density of 1 W cm(-) (2) without weight loss and tumor recurrence. No obvious systematic toxicity is observed for the injected mice, indicating the good biocompatibility of this kind of multifunctional drug nanocomposites. This work highlights the great potential of drug-nanostructure-based multifunctional core/shell nanpocomposite for highly efficient cancer therapy.

Enhanced Targeted Delivery of Cyclodextrin‐Based Supermolecules by Core–Shell Nanocapsules for Magnetothermal Chemotherapy

“…The tumor sizes and body weight of mice were measured every day lasting for 15 d after treatment. The tumor volume and relative tumor volume were calculated by the following equations . All measurements were performed in triplicatewhere L stands for the longest diameter and W is the shortest diameterwhere V is the tumor volume after treatment and V ′ is the initial tumor volume.…”

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

“…Upon laser irradiation, the photothermal heating of the gold nanoshells induced the micelles to collapse and resulted in doxorubicin release [63]. This photothermal approach can be used to induce deformation and rupture of gold nanoshells, where the therapeutic payload has been encapsulated, thus triggering its controlled release [84,[86][87][88]. A mechanism describing how drugs are released from these AuNMs when combined with laser-induced thermal therapy has also been proposed [89].…”

Dual-Targeted Multifunctional Nanoparticles for Magnetic Resonance Imaging Guided Cancer Diagnosis and Therapy

“…[8][9][10] Photothermal therapy (PTT) is an approach to employ photothermal agents with a strong absorbance in the near-infrared (NIR) region to produce heat to kill target cells with minimal side effects. During last decades, a wide range of PTT agents such as gold nanomaterials (e.g., gold nanorods, nanocages, and nanoshells), [11][12][13][14][15] carbon nanomaterials (e.g., carbon nanotubes, and graphene) [16][17][18][19][20] and many other materials (e.g., polydopamine, poly(4-styrenesulfonate), and indocyanine green (ICG)) [21][22] have been widely explored. Chemotherapy is to use drugs to destroy cancer cells.…”