Functional constipation as a risk factor for pyelonephritis and recurrent urinary tract infection in children

Axelgaard, Sofie; Kristensen, Rasmus; Kamperis, Konstantinos; Hagstrøm, Søren; Jessen, Alexander Slot; Borch, Luise

doi:10.1111/apa.16608

Cited by 4 publications

(3 citation statements)

References 31 publications

(81 reference statements)

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“…Many authors observed a positive correlation of BBD and rUTI [ 43 , 44 , 45 , 46 ]. Axelgaard et al found that constipation was positively associated with rUTI in children, particularly girls aged 4 to 18 years without CAKUT [ 47 ]. In our study group, we observed a similar dependence.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

Daniel,

Szymanik-Grzelak,

Sierdziński

et al. 2024

Microorganisms

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Urinary tract infections (UTIs) rank among the most prevalent bacterial infections in children. Probiotics appear to reduce the risk of recurrence of UTIs. This study aimed to evaluate whether probiotics containing Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 therapy prevent UTIs in the pediatric population compared to a placebo. A superiority, double-blind, randomized, controlled trial was conducted. In total, 54 children aged 3–18 years with recurrent UTIs or ≥one acute pyelonephritis and ≥one risk factor of recurrence of UTIs were randomly assigned (27 patients in each arm) to a 90-day probiotic or placebo arm. The age, sex, diagnosis, renal function, risk factors, and etiology of UTIs did not vary between the groups. During the intervention, 26% of children taking the probiotic had episodes of UTI, and it was not significantly less than in the placebo group. The number of UTI episodes during the intervention and the follow-up period decreased significantly in both groups, but the difference between them was insignificant. We observed a decrease in UTIs during the study of almost 50% in the probiotic group compared to the placebo group. Probiotics can be used as natural, safe prophylaxis for children with risk factors for UTIs in whom antibiotic prevention is not indicated.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

Daniel,

Szymanik-Grzelak,

Sierdziński

et al. 2024

Microorganisms

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“…It impacts children, family members, caregivers, and medical professionals [11,31,138,139]. Reduced stool frequency causes fecal incontinence (FI) [140], anal fissures [141], recurrent urinary tract infections (RUTI) [142], and enuresis in children [143]. In individuals with severe constipation, stool became solid.…”

Section: Impact Of Constipationmentioning

confidence: 99%

“…Multiple research projects reported that pediatric patients with chronic constipation often concurrently suffer from RUTI and pyelonephritis. These patients frequently had diverse kidney and urinary tract anatomical abnormalities revealed through X-ray and ultrasonographic examination [142,151,152]. Longstanding constipation has the potential to alter the detrusor muscle activity of the urinary bladder and augment excitatory serotoninergic function, increasing the likelihood of enuresis or urine incontinence [143,[153][154][155][156].…”

Section: Impact Of Constipationmentioning

confidence: 99%

Constipation: A Pristine Universal Pediatric Health Delinquent

Chowdhury,

Sinha,

Kumar

et al. 2024

Cureus

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Constipation suffered by children is a global public health problem. Functional constipation (FC) brings about deteriorating effects in the children's lives who suffer from it. The risk factors for the development of constipation include the consumption of a diet low in fiber and high in calories (such as the consumption of fast food), a sedentary lifestyle with a lack of exercise, a family history of constipation, and emotional and psychological stress endured by children in their families. It is one of the most common causes of stomachaches in children. FC may lead to fecal incontinence (FI), anal fissures, recurrent urinary tract infections (RUTI), and enuresis in children. Severe constipation may result in stool becoming rock-hard and inflexible in the rectum, which is clinically identified as fecal impaction. It is imperative to perform clinical evaluation and treatment, including pharmacological (the use of stimulant and osmotic laxatives) and nonpharmacological (education, changes in diet, intervention to promote positive behavior and address any emotional issues, toilet training, and physiotherapy for the pelvic floor) interventions. In the case of refractory patients, neuromodulation, the irrigation of the anal canal, and surgical management may be needed. It is essential to lead a healthy, stress-free lifestyle with plenty of exercise and a balanced diet rich in fiber (such as fruits and vegetables) so children can have regular bowel habits and thrive.

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Functional constipation as a risk factor for pyelonephritis and recurrent urinary tract infection in children

et al. 2022

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Urinary tract infection (UTI) is among the most common bacterial infections in childhood affecting up to 8.4% of girls and 1.7% of boys within the first 6 years of life. 1,2 Pyelonephritis is defined as an upper UTI involving the upper urinary tract and kidney parenchyma. This potentially serious condition can lead to renal scarring, 3,4 which can further result in loss of kidney function and long-term sequelae such as hypertension. 5 Approximately 85-95% of upper and lower UTIs are caused by Escherichia coli (E. coli). Klebsiella, Proteus, Enterococcus and Enterobacter species are other common organisms. 6 Kidney or urinary tract (UT) abnormalities, for example vesicoureteral reflux, (VUR) are well-established risk factors associated with UTI. 3,7 However, our knowledge on risk factors associated with UTI in children without kidney or UT abnormalities is limited. Few

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Functional constipation as a risk factor for pyelonephritis and recurrent urinary tract infection in children

Cited by 4 publications

References 31 publications

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

Constipation: A Pristine Universal Pediatric Health Delinquent

Functional constipation as a risk factor for pyelonephritis and recurrent urinary tract infection in children

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