Functional connectivity within the network of verticality

Lemaire, Camille; Jaillard, Assia; Gornushkina, I.; Piscicelli, Céline; Dai, Shenhao; Pichat, Cédric; Detante, Olivier; Hommel, Marc; Baciu, Monica; Pérennou, Dominic

doi:10.1016/j.rehab.2020.101463

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…An interhemispheric connection of the PIVC has been described by DTI in humans via the splenium of the CC and might be involved in the reorganization of verticality perception after ischemic infarcts. (Kirsch et al 2016;Wirth et al 2018;Lemaire et al 2021). Indeed, in patients with subcortical ischemic strokes presenting with vestibular symptoms, vestibular recovery/compensation took place over time and was accompanied by volumetric changes in the splenium of the CC using voxel-based morphometry (Conrad et al 2022a, b).…”

Section: Corpus Callosummentioning

confidence: 99%

“…A lesion that interrupts interhemispheric connectivity between the multisensory vestibular cortex (PIVC) of both hemispheres might suffice to disturb interhemispheric alignment of multisensory signals and thus induce cortical vertigo (Dieterich and Brandt 2015 ). One candidate structure could be the splenium of the corpus callosum as it contains the interhemispheric connection between both PIVCs (Kirsch et al 2016 ; Wirth et al 2018 ; Lemaire et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the rare cases of cortical vertigo using disconnectome mapping

et al. 2022

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In rare cases, cortical infarcts lead to vertigo. We evaluated structural and functional disconnection in patients with acute vertigo due to unilateral ischemic cortical infarcts compared to infarcts without vertigo in a similar location with a focus on the connectivity of the vestibular cortex, i.e., the parieto-opercular (retro-)insular cortex (PIVC). Using lesion maps from the ten published case reports, we computed lesion–functional connectivity networks in a set of healthy individuals from the human connectome project. The probability of lesion disconnection was evaluated by white matter disconnectome mapping. In all ten cases with rotational vertigo, disconnections of interhemispheric connections via the corpus callosum were present but were spared in lesions of the PIVC without vertigo. Further, the arcuate fascicle was affected in 90% of the lesions that led to vertigo and spared in lesions that did not lead to vertigo. The lesion–functional connectivity network included vestibulo-cerebellar hubs, the vestibular nuclei, the PIVC, the retro-insular and posterior insular cortex, the multisensory vestibular ventral intraparietal area, motion-sensitive areas (temporal area MT+ and cingulate visual sulcus) as well as hubs for ocular motor control (lateral intraparietal area, cingulate and frontal eye fields). However, this was not sufficient to differentiate between lesions with and without vertigo. Disruption of interhemispheric connections of both PIVC via the corpus callosum and intra-hemispheric disconnection via the arcuate fascicle might be the distinguishing factor between vestibular cortical network lesions that manifest with vertigo compared to those without vertigo.

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Section: Corpus Callosummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluating the rare cases of cortical vertigo using disconnectome mapping

et al. 2022

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“…However, this suggestion remains to be demonstrated by further studies. How can we explain that although the graviceptive network is potentially bilateral, 8,12 the internal model of verticality is strongly lateralized in the right hemisphere? As suggested for other functions, 46 one may assume that this is due to human evolution and the need to increase function efficiency, which led to the specialization of each hemisphere.…”

Section: Lateropulsion Prevalence As a Function Of Stroke Sidementioning

confidence: 99%

“…This definitively advocates for the strong right hemispheric predominance for the control of the body upright, as suggested in some studies. 1,7,8,10,17,43,44 The fact that lateropulsion prevalence is not negligible in the acute phase after a left hemispheric stroke may be explained in part by a potential bilateral graviceptive network 8,12 and also by the existence of a diaschisis altering the function of both hemispheres during the days after the stroke, 45 whatever the side. Then the release of the diaschisis might explain why the ratio of lateropulsion after right vs left hemispheric stroke increases with time, multiplied by 4 between acute and late subacute phases.…”

Section: Lateropulsion Prevalence As a Function Of Stroke Sidementioning

confidence: 99%

“…7,10 Individuals align their body onto this erroneous reference of verticality 7,10 in relation to a damaged graviceptive network. 7,8,[10][11][12] The increasing interest in lateropulsion mechanisms and consequences is starting to be translated into efforts to design specific interventional studies. 4,5,13 These efforts require some basic knowledge of epidemiology, which is insufficient because many studies focused on a few severe forms in individuals called pushers.…”

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confidence: 99%

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Lateropulsion Prevalence After Stroke

et al. 2022

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Background and Objectives:Lateropulsion is a deficit of active body orientation with respect to gravity in the frontal plane, mostly observed after a stroke. It magnifies mobility limitations and so represents an emerging target in rehabilitation. Efforts to design specific interventional studies require some basic knowledge of epidemiology, which is insufficient today because many studies focused on a few severe forms in individuals called pushers. The objectives of this study were to bridge this gap.Methods:We systematically searched MEDLINE, EMBASE, CINAHL, and Cochrane Clinical Trials up to 31 May 2021 for original research reporting a prevalence or incidence of post-stroke lateropulsion. We followed MOOSE and PRISMA guidelines. Eligibility for inclusion, data extraction, and study quality (Joanna Briggs Institute guidelines) were evaluated by two reviewers who used a standardized protocol: PROSPERO (CRD42020175037). A random-effects meta-analysis was used to obtain the pooled prevalence, whose heterogeneity was investigated by subgroup analysis (stroke locations and post-stroke phases) and meta-regression.Results:We identified 22 studies (5125 individuals; mean age 68.5 years; 42.6% female; assessed 24 days, on average, after stroke), most published after 2000. The studies’ quality was adequate, with only 8 (36.4%) showing risk of bias. The pooled lateropulsion prevalence was 55.1% (95% confidence interval [CI] [35.9–74.2]) and was consistent across assessment tools. After supratentorial stroke, lateropulsion prevalence was 41% (95%CI [33.5–48.5]), and only 12.5% (95%CI [9.2–15.9]) in individuals with severe lateropulsion, called pushers. Meta-regression did not reveal any effect of age, sex, geographic region, publication year, or study quality. Lateropulsion prevalence progressively decreased from 52.8% (95%CI [40.7–65]) in the acute phase to 37% (95%CI [26.3–47.7]) in the early subacute phase and 22.8% (95%CI [0–46.3]) in the late subacute phase. The ratio of right- to left-hemispheric stroke with lateropulsion increased as a function of time: 1.7 in the acute phase to 7.7 in the late subacute phase. After infratentorial stroke, lateropulsion prevalence was very high, reaching 83.2% (95%CI [63.9–100.3]).Conclusions:Post-stroke lateropulsion prevalence is high, which appeals for its systematic detection to guide early interventions. Uprightness is predominantly controlled from the right hemisphere.

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