A B S T R AC T :Postural abnormalities such as postural deviations affect nearly all patients with advanced Parkinson's disease and represent an important source of disability. Although their existence has long been known, their management remains a challenge as they respond poorly to medication, brain surgery, or physiotherapy. Improving management strategies will require better understanding of the mechanisms underlying such postural deformities.In this review on the pathophysiology of Pisa syndrome, we examine the data supporting the central and peripheral hypotheses that attempt to explain these lateral trunk deviations. Although the pathophysiology is very probably multifactorial, the bulk of the data supports central, rather than peripheral, hypotheses. The central hypotheses that are best supported by both animal studies and clinical data include asymmetry of basal ganglia output and abnormalities in the central integration of sensory information. Further studies are needed to elucidate the pathophysiology underlying Pisa syndrome. V C 2014 International Parkinson and Movement Disorder Society
ObjectiveTo test the hypothesis that the impaired body orientation with respect to gravity (lateropulsion) would play a key role in post-stroke balance and gait disorders.MethodsCohort study of 220 individuals consecutively admitted to a neurorehabilitation ward after a first hemisphere stroke (Cohort DOBRAS 2012-2018, ClinicalTrials.gov: NCT03203109), with clinical data systematically collected at 1 month, then at discharge. Primary outcomes were balance and gait disorders, quantified by the Postural Assessment Scale for Stroke (PASS) and the modified Fugl-Meyer Gait Assessment (mFMA), to be explained by all deficits on day 30, including lateropulsion assessed with the Scale for Contraversive Pushing (SCP). Statistics comprised linear regression analysis, uni- and multivariate analyses, and receiver operating characteristic curves.ResultsLateropulsion was frequent, especially after right hemisphere stroke (RHS, D30, 48%; discharge 24%), almost always in right-handers. Among all deficits, impaired body orientation (lateropulsion) had the most detrimental effect on balance and gait. After RHS, balance disorders were proportional to lateropulsion severity, which alone explained almost all balance disorders at initial assessment (90%; 95% confidence interval [CI] [86–94], p<0.001) and at discharge (92%, 95%CI [89–95], p<0.001) and also the greatest part of gait disorders at initial assessment (66%, 95%CI [56–77], p<0.001) and at discharge (68%, 95%CI [57–78], p<0.001).ConclusionsLateropulsion is the primary factor altering post-stroke balance and gait at the subacute stage and therefore should be systematically assessed. Post-stroke balance and gait rehabilitation should incorporate techniques devoted to misorientation with respect to gravity.
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