Functional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State Fluctuations

Lowe, Mark J.; Mock, Bruce H.; Sorenson, James A.

doi:10.1006/nimg.1997.0315

Cited by 1,273 publications

(1,078 citation statements)

References 28 publications

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“…Similarly, participation of these regions for left-hand movements to the recovery of motor skills has amply been documented in stroke patients Rossini et al, 2003;Ward, 2005) or patients with a tumor or undergoing surgery (Duffau, 2000;Duffau and Capelle, 2001a,b;Krainik et al, 2004), or with multiple sclerosis (Rocca et al, 2005). More recently, studies of functional connectivity, particularly on healthy subjects in resting state (Biswal et al, 1995;Lowe et al, 1998;Xiong et al, 1999) have confirmed that these regions of the motor network are strongly correlated to one another.…”

Section: Discussionmentioning

confidence: 94%

Partial correlation for functional brain interactivity investigation in functional MRI

et al. 2006

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Section: Discussionmentioning

confidence: 94%

Partial correlation for functional brain interactivity investigation in functional MRI

et al. 2006

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“…The training‐related monotonic increases in rsFC of the SMART group yielded greater connectivity strength of the SMART than the BHW at TP 3 ( p NBS = 0.0004). The map for the ROIs overlaid onto the Yeo atlas (Yeo et al., 2011) revealed that the ROIs were affiliated with the default‐mode network (DMN) (Greicius, Krasnow, Reiss, & Menon, 2002; Raichle et al., 2001), somatomotor network (SMN) (Smith et al., 2009), and visual network (VN) (Lowe, Mock, & Sorenson, 1998) (Figure S6). The subsequent large‐scale network‐based assessment of connectivity increases over time for the SMART group relative to the BHW group exhibited that increases in connectivity primarily occurred between the DMN and SMN, and between the DMN and VN (Figure 7a).…”

Section: Resultsmentioning

confidence: 99%

Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

et al. 2017

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IntroductionPrior studies have demonstrated training‐induced changes in the healthy adult brain. Yet, it remains unclear how the injured brain responds to cognitive training months‐to‐years after injury.MethodsSixty individuals with chronic traumatic brain injury (TBI) were randomized into either strategy‐based (N = 31) or knowledge‐based (N = 29) training for 8 weeks. We measured cortical thickness and resting‐state functional connectivity (rsFC) before training, immediately posttraining, and 3 months posttraining.ResultsRelative to the knowledge‐based training group, the cortical thickness of the strategy‐based training group showed diverse temporal patterns of changes over multiple brain regions (p vertex < .05, p cluster < .05): (1) increases followed by decreases, (2) monotonic increases, and (3) monotonic decreases. However, network‐based statistics (NBS) analysis of rsFC among these regions revealed that the strategy‐based training group induced only monotonic increases in connectivity, relative to the knowledge‐based training group (|Z| > 1.96, pNBS < 0.05). Complementing the rsFC results, the strategy‐based training group yielded monotonic improvement in scores for the trail‐making test (p < .05). Analyses of brain–behavior relationships revealed that improvement in trail‐making scores were associated with training‐induced changes in cortical thickness (p vertex < .05, p cluster < .05) and rsFC (p vertex < .05, p cluster < .005) within the strategy‐based training group.ConclusionsThese findings suggest that training‐induced brain plasticity continues through chronic phases of TBI and that brain connectivity and cortical thickness may serve as markers of plasticity.

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“…As noise removal was performed in the time‐domain (frequency band pass filtering; e.g., 0.01–0.08 Hz) and a model of the CSF (by regressing out the covariate of CSF signals), it may be difficult to completely remove effects of vascular components (such as cardiac pulsation and blood vessels) in a variation in signals in brain tissues (Lowe et al. 1998; Shmueli et al. 2007; Murphy et al.…”

Section: Methodsmentioning

confidence: 99%

Long‐term acclimatization to high‐altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain

Chen

Li²,

Han³

et al. 2016

Brain and Behavior

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BackgroundStructural and functional networks can be reorganized to adjust to environmental pressures and physiologic changes in the adult brain, but such processes remain unclear in prolonged adaptation to high‐altitude (HA) hypoxia. This study aimed to characterize the interhemispheric functionally and structurally coupled modifications in the brains of adult HA immigrants.MethodsWe performed resting‐state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in 16 adults who had immigrated to the Qinghai‐Tibet Plateau (2300–4400 m) for 2 years and in 16 age‐matched sea‐level (SL) controls. A recently validated approach of voxel‐mirrored homotopic connectivity (VMHC) was employed to examine the interhemispheric resting‐state functional connectivity. Areas showing changed VMHC in HA immigrants were selected as regions of interest for follow‐up DTI tractography analysis. The fiber parameters of fractional anisotropy and fiber length were obtained. Cognitive and physiological assessments were made and correlated with the resulting image metrics.ResultsCompared with SL controls, VMHC in the bilateral visual cortex was significantly increased in HA immigrants. The mean VMHC value extracted within the visual cortex was positively correlated with hemoglobin concentration. Moreover, the path length of the commissural fibers connecting homotopic visual areas was increased in HA immigrants, covarying positively with VMHC.ConclusionsThese observations are the first to demonstrate interhemispheric functional and structural connectivity resilience in the adult brain after prolonged HA acclimatization independent of inherited and developmental effects, and the coupled modifications in the bilateral visual cortex indicate important neural compensatory mechanisms underlying visual dysfunction in physiologically well‐acclimatized HA immigrants. The study of human central adaptation to extreme environments promotes the understanding of our brain's capacity for survival.

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Functional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State Fluctuations

Cited by 1,273 publications

References 28 publications

Partial correlation for functional brain interactivity investigation in functional MRI

Partial correlation for functional brain interactivity investigation in functional MRI

Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

Long‐term acclimatization to high‐altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain

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