Functional connectivity differences in the amygdala are related to the antidepressant efficacy of ketamine in patients with anxious depression

Yuan, Shiqi; Luo, Xin; Chen, Xiaoyu; Wang, Mingqia; Hu, Yiru; Zhou, Yanling; Ning, Yuping; Zhang, Bin

doi:10.1016/j.jad.2022.09.125

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…In addition, our study revealed that the stronger RSFC between the left LBA and the precuneus was related to the antidepressant effect of ketamine. This finding was similar to the result reported by Yuan et al [ 22 ]. Their study showed that in all anxiety depression patients, the RSFC between the LBA and left precuneus of ketamine responders at baseline was stronger than that in nonresponders, and this RSFC was related to the reduction in depressive symptoms.…”

Section: Discussionsupporting

confidence: 93%

“…One study reported that the strength of the RSFC between the left SFA and the left posterior fusiform gyrus increased with improvements in depressive symptoms after electroconvulsive therapy in MDD patients [ 21 ]. Additionally, another study showed that the baseline RSFC of the left LBA and left precuneus in treatment responders was stronger than that in nonresponders in patients with anxiety-related depression, and the RSFC between the left LBA and left precuneus could predict treatment outcome [ 22 ]. However, the role of RSFC in the amygdala subregion during ketamine treatment remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

Liu,

Wang,

Lan

et al. 2024

Eur. Psychiatr.

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Background. Amygdala subregion-based network dysfunction has been determined to be centrally implicated in major depressive disorder (MDD). Little is known about whether ketamine modulates amygdala subarea-related networks. We aimed to investigate the relationships between changes in the resting-state functional connectivity (RSFC) of amygdala subregions and ketamine treatment and to identify important neuroimaging predictors of treatment outcomes. Methods. Thirty-nine MDD patients received six doses of ketamine (0.5 mg/kg). Depressive symptoms were assessed, and magnetic resonance imaging (MRI) scans were performed before and after treatment. Forty-five healthy controls underwent one MRI scan. Seed-tovoxel RSFC analyses were performed on the amygdala subregions, including the centromedial amygdala (CMA), laterobasal amygdala (LBA), and superficial amygdala subregions. Results. Abnormal RSFC between the left LBA and the left precuneus in MDD patients is related to the therapeutic efficacy of ketamine. There were significant differences in changes in bilateral CMA RSFC with the left orbital part superior frontal gyrus and in changes in the left LBA with the right middle frontal gyrus between responders and nonresponders following ketamine treatment. Moreover, there was a difference in the RSFC of left LBA and the right superior temporal gyrus/middle temporal gyrus (STG/MTG) between responders and nonresponders at baseline, which could predict the antidepressant effect of ketamine on Day 13. Conclusions. The mechanism by which ketamine improves depressive symptoms may be related to its regulation of RSFC in the amygdala subregion. The RSFC between the left LBA and right STG/MTG may predict the response to the antidepressant effect of ketamine.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

Liu,

Wang,

Lan

et al. 2024

Eur. Psychiatr.

Self Cite

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“…Neuroimaging studies 24 have also found that patients with depression may experience structural and functional abnormalities in the amygdala, such as gray matter volume reduction and changes in connection strength. Some antidepressant treatments, 25 such as pharmacotherapy and cognitive behavioral therapy, 26 may improve symptoms of depression by altering amygdala activity.…”

Section: Pathogenesismentioning

confidence: 99%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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Depression is a prevalent mental disorder and has a profound impact on an individual’s psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on. In the incidence of depression, covering all ages, but still mainly young and middle-aged women. Traditional treatments for depression mainly rely on medication and psychotherapy, but these methods are not effective for all patients and are often accompanied by certain side effects. Therefore, finding safe and effective alternative or adjuvant treatments has become a priority. Here we highlight the research progress of acupuncture in the treatment of depression and to explore the mechanism of acupuncture in the treatment of depression. Acupuncture treatment of depression is an ancient and effective method, the mechanism involves multiple biological pathways, for example, by regulating neurotransmitter levels, regulating the neuroendocrine axis, improving neuroplasticity, anti-inflammatory and other effects, improving emotional state and play an antidepressant role. To provide evidence to support the widespread use of acupuncture in clinical practice. We hope to provide new treatment ideas and methods for patients with depression, and even reduce the incidence of depression.

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Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study

Luo,

Wang,

Gou

et al. 2024

J Neural Transm

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Functional connectivity differences in the amygdala are related to the antidepressant efficacy of ketamine in patients with anxious depression

Cited by 6 publications

References 44 publications

Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study

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