Functional comparison of annexin V analogues labeled indirectly and directly with iodine-124

Radiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma

“…However similar differences in radioiodination yields due to a change in radioisotope have previously been reported. For example, the radioiodination of N -hydroxysuccinimidyl-4-tributylstannylbenzoate proceeds in 60–70 % yield when labelled with [ 125 I] compared to 20–40 % with [ 124 I] [19]. However in this case the [ 124 I]iodination yield remains high for the synthesis of [ 124 I] m IBG and generates ample amount of [ 124 I]product for PET application.…”

Radiohalogenated Prostate-Specific Membrane Antigen (PSMA)-Based Ureas as Imaging Agents for Prostate Cancer

“…To a solution of 1 (0.120 g, 0.148 mmol) in CH 2 Cl 2 (6 mL) was added triethylamine (0.1 mL, 0.712 mmol), followed by N -hydroxysuccinimidyl-4-tributylstannylbenzoate 48 (0.075 g, 0.147 mmol). After stirring for 2 h at room temperature, the reaction mixture was condensed on a rotary evaporator.…”

In Vivo Detection of Apoptosis

“…In addition, researchers have tested chemically modified annexin V with a variety of different in vitro assays and have generally concluded that the protein can withstand up to average derivatization stoichiometry of 2 mol/mol without a loss in PS binding affinity (77)(78)(79)(80)(81). However, these results have been called into question by the work of Bazzi and Nelsestuen (82), who found that the binding of annexins to membranes is negatively cooperative (i.e., a negative Hill effect) with respect to protein.…”