Functional characterization of BcrR: a one-component transmembrane signal transduction system for bacitracin resistance

Darnell, Rachel L.; Nakatani, Yoshio; Knottenbelt, Melanie K.; Gebhard, Susanne; Cook, Gregory M.

doi:10.1099/mic.0.000781

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…While combining input and output domains on one protein leads to sterical constraints on responses to extracellular cues, membrane-spanning 1CSs-which respond to extracellular cueshave been described, and approximately 5% of all 1CSs are predicted to be membrane-anchored proteins (70). Examples include BcrR, which mediates bacitracin resistance in Enterococcus faecalis (13), and CadC, which is involved in the acid stress response of Escherichia coli (8).…”

Section: Bacterial Signal Transduction: Connecting Stimuli With Cellu...mentioning

confidence: 99%

Past, Present, and Future of Extracytoplasmic Function σ Factors: Distribution and Regulatory Diversity of the Third Pillar of Bacterial Signal Transduction

Mascher

2023

Annu. Rev. Microbiol.

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Responding to environmental cues is a prerequisite for survival in the microbial world. Extracytoplasmic function σ factors (ECFs) represent the third most abundant and by far the most diverse type of bacterial signal transduction. While archetypal ECFs are controlled by cognate anti-σ factors, comprehensive comparative genomics efforts have revealed a much higher abundance and regulatory diversity of ECF regulation than previously appreciated. They have also uncovered a diverse range of anti-σ factor–independent modes of controlling ECF activity, including fused regulatory domains and phosphorylation-dependent mechanisms. While our understanding of ECF diversity is comprehensive for well-represented and heavily studied bacterial phyla—such as Proteobacteria, Firmicutes, and Actinobacteria (phylum Actinomycetota)—our current knowledge about ECF-dependent signaling in the vast majority of underrepresented phyla is still far from complete. In particular, the dramatic extension of bacterial diversity in the course of metagenomic studies represents both a new challenge and an opportunity in expanding the world of ECF-dependent signal transduction. Expected final online publication date for the Annual Review of Microbiology, Volume 77 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Bacterial Signal Transduction: Connecting Stimuli With Cellu...mentioning

confidence: 99%

Past, Present, and Future of Extracytoplasmic Function σ Factors: Distribution and Regulatory Diversity of the Third Pillar of Bacterial Signal Transduction

Mascher

2023

Annu. Rev. Microbiol.

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“…It is typically administered in the form of bacitracin methylene disalicylate (BMD) or zinc-bacitracin (BACN-Z) [ 95 , 96 ]. Bacitracin resistance has been correlated with the presence of the bcrR gene encoding a unique membrane-bound one-component system through a putative ATP-binding cassette ( bcrAB ) transporter [ 97 , 98 ].…”

Section: Some Antimicrobials Used In Conventional Poultrymentioning

confidence: 99%

Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review

Mak

Rehman

Kiarie

et al. 2022

J Animal Sci Biotechnol

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Economic losses and market constraints caused by bacterial diseases such as colibacillosis due to avian pathogenic Escherichia coli and necrotic enteritis due to Clostridium perfringens remain major problems for poultry producers, despite substantial efforts in prevention and control. Antibiotics have been used not only for the treatment and prevention of such diseases, but also for growth promotion. Consequently, these practices have been linked to the selection and spread of antimicrobial resistant bacteria which constitute a significant global threat to humans, animals, and the environment. To break down the antimicrobial resistance (AMR), poultry producers are restricting the antimicrobial use (AMU) while adopting the antibiotic-free (ABF) and organic production practices to satisfy consumers’ demands. However, it is not well understood how ABF and organic poultry production practices influence AMR profiles in the poultry gut microbiome. Various Gram-negative (Salmonella enterica serovars, Campylobacter jejuni/coli, E. coli) and Gram-positive (Enterococcus spp., Staphylococcus spp. and C. perfringens) bacteria harboring multiple AMR determinants have been reported in poultry including organically- and ABF-raised chickens. In this review, we discussed major poultry production systems (conventional, ABF and organic) and their impacts on AMR in some potential pathogenic Gram-negative and Gram-positive bacteria which could allow identifying issues and opportunities to develop efficient and safe production practices in controlling pathogens.

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“…The adaptive responses to peripheral signals are mainly generated by transcriptional regulators through two systems, one-component, and two-component signal transmission systems. These systems scan small molecular proteins inside and outside the cell and modulate gene expression to provide the appropriate physiological response to the prevailing conditions [88].…”

Section: Gi-tract Prokaryotes Signalingmentioning

confidence: 99%

Large Association of GI Tract Microbial Community with Immune and Nervous Systems

Kazempour¹

2022

Immunology of the GI Tract - Recent Advances

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The gut microbial community has amazing effects on our immune system and nervous system through three pathways: cell signaling, electron transfer, and biological cycles. However, this relationship is two-way and has its own risks or benefits. Except for the brain, there is no place in the body that does not have cytokines (but not all of them). Cytokines are one of the most important immune molecules that play an important role in maintaining homeostasis in our body and the connection between the central nervous system and our immune system. So it is clear that many beneficial microbes in the gut are stimulated when we are hungry or when our nervous system is under pressure from external stimuli. These microbes die or damage intestinal epithelial tissues and stimulate immune molecules such as interleukins or IFNs upstream.

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Functional characterization of BcrR: a one-component transmembrane signal transduction system for bacitracin resistance

Cited by 7 publications

References 27 publications

Past, Present, and Future of Extracytoplasmic Function σ Factors: Distribution and Regulatory Diversity of the Third Pillar of Bacterial Signal Transduction

Past, Present, and Future of Extracytoplasmic Function σ Factors: Distribution and Regulatory Diversity of the Third Pillar of Bacterial Signal Transduction

Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review

Large Association of GI Tract Microbial Community with Immune and Nervous Systems

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