Functional characteristics of the intercellular adhesion molecule-1 (CD54) expressed on cytotoxic human blood lymphocytes

Wang, P.; Vánky, Farkas; Li, S.-L.; Patarroyo, Manuel Elkín; Klein, Eva

doi:10.1016/0008-8749(90)90261-o

Cited by 23 publications

(9 citation statements)

References 39 publications

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“…Its function has been widely studied in NK target cells but little in NK effector cells. NK cell expressed CD54 strengthens the NK-target cell and the NK-leukocyte interactions and may influence several events during lytic interplay [ 33 ]. After activation, both control and patient cells up-regulated CD54 expression with mean values higher on patient NK cells.…”

Section: Discussionmentioning

confidence: 99%

Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG)

et al. 2016

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BackgroundPMM2-CDG is the most common N-glycosylation defect and shows an increased risk of recurrent and/or severe, sometimes fatal, infections in early life. We hypothesized that natural killer (NK) cells, as important mediators of the immune response against microbial pathogens and regulators of adaptive immunity, might be affected in this genetic disorder.ObjectiveTo evaluate possible defects on PMM2-CDG NK peripheral blood cell number, killing activity and expression of membrane receptors.MethodsWe studied fresh and activated NK cells from twelve PMM2-CDG cells. The number and expression of lymphoid surface receptors were studied by flow cytometry. The NK responsiveness (frequency of degranulated NK cells) and killing activity against K562 target cells was determined in the NK cytotoxicity assay.ResultsWe found an increase of blood NK cells in three patients with a severe phenotype. Two of them, who had suffered from moderate/severe viral infections during their first year of life, also had reduced T lymphocyte numbers. Patient activated NK cells showed increased expression of CD54 adhesion molecule and NKG2D and NKp46 activating receptors. NKp46 and 2B4 expression was inversely correlated with the expression of NKG2D in activated PMM2-CDG cells. Maximal NK activity against K562 target cells was similar in control and PMM2-CDG cells. Interestingly, the NK cell responsiveness was higher in patient cells. NKG2D and specially CD54 increased surface expression significantly correlated with the increased NK cell cytolytic activity according to the modulation of the killer activity by expression of triggering receptors and adhesion molecules.ConclusionsOur results indicate that hypoglycosylation in PMM2-CDG altered NK cell reactivity against target cells and the expression of CD54 and NKG2D, NKp46 and 2B4 activating receptors during NK cell activation. This suggests a defective control of NK cell killing activity and the overall anti-viral immune response in PMM2-CDG patients. The present work improves our understanding of the immunological functions in PMM2-CDG and possibly in other CDG-I types.

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Section: Discussionmentioning

confidence: 99%

Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG)

et al. 2016

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“…(28) Therefore, ICAM-1 is important for the local immune response, i.e. the activity of NK and LAK cells is suppressed by administration of anti-ICAM-1 antibody(8,9) and serum circulating ICAM-1 suppresses the adhesion of T cells by binding to LFA-1 and inhibits NK and LAK cell activity. (7,29) Based on these reports, we can hypothesize that ICAM-1 has an important immunosuppressive effect and is involved in carcinogenesis and aggravates cancer progression and this can be applied to our analysis.…”

Section: Discussionmentioning

confidence: 99%

Expression of Intercellular Adhesion Molecule-1 and E-Selectin in Gastric Cancer and Their Clinical Significance

et al. 2012

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PurposeAmong cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer.Materials and MethodsThe protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients.ResultsIn western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).ConclusionsIntercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

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“…6 The LFA-1/ICAM-1 pair serves as major adherence receptor required for intercellular interaction and communication of immune contact cells. 46,47 It has been reported that CD30 stimulation induces homotypic cell aggregation of human lymphoma line. 48 It has been reported recently that CD30 signals strongly upregulate ICAM-1 expression and increase ICAM-1-dependent cell clustering of lymphocytes in normal activated murine lymph node cells.…”

Section: Cd30 Induces Binding Of Nf-jb Family Proteins To the Nf-jb Ementioning

confidence: 99%

Retracted: Transactivation of the ICAM‐1 gene by CD30 in Hodgkin's lymphoma

Uchihara

Matsuda

Okudaira

et al. 2005

Intl Journal of Cancer

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Functional characteristics of the intercellular adhesion molecule-1 (CD54) expressed on cytotoxic human blood lymphocytes

Cited by 23 publications

References 39 publications

Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG)

Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG)

Expression of Intercellular Adhesion Molecule-1 and E-Selectin in Gastric Cancer and Their Clinical Significance

Retracted: Transactivation of the ICAM‐1 gene by CD30 in Hodgkin's lymphoma

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