<i>Retracted:</i> Transactivation of the <i>ICAM‐1</i> gene by CD30 in Hodgkin's lymphoma

Uchihara, Jun-Nosuke; Matsuda, Takehiro; Okudaira, Taeko; Ishikawa, Chie; Masuda, Masato; Horie, Ryouichi; Watanabe, Toshiki; Ohta, Takao; Takasu, Nobuyuki; Mori, Nozomu

doi:10.1002/ijc.21427

Cited by 6 publications

(6 citation statements)

References 51 publications

(97 reference statements)

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“…Additionally, the expression of MMP9 by human promyelocytic leukemia HL-60 cell line has been associated with intercellular adhesion molecule-1 (ICAM-1) shedding into the cell medium [28], which would suggest another explanation. ICAM-1, which is overexpressed by HRS cells [29], regulates leukocyte homing, activation, and effector functions like T-cell and Natural Killer (NK) cell-mediated cytotoxicity. ICAM-1 shedding by tumor cells into the microenvironment might be associated with T/NK-cell mediated death resistance, since soluble ICAM-1 would act as a decoy ligand, binding surface receptors of NK-cells and preventing them from recognizing molecules displayed on the surface of the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

2013

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Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma.

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Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

2013

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Section: Discussionmentioning

confidence: 94%

“…In addition, the remarkable correlation between CD69 and ICAM-1 expression indicates that the latter molecule may be used as a sensitive NK cell activation marker. However, an exception was observed by the TLR2 agonist, Pam 3 CyS, which was able to induce CD69 expression but failed to up-regulate ICAM-1, suggesting an independent mechanism for modulation of these two activation markers [47].Recent studies have demonstrated that human NK cells efficiently enhance CD4 1 as well as CD8 1 T-cell proliferation. This process is dependent on direct contact-mediated interactions between ligands for TCR co-stimulatory receptors expressed on stimulated human NK cells such as CD80, CD86, CD70, OX40L and 2B4 receptors [16,17,48].…”

mentioning

confidence: 99%

NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

et al. 2009

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Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T-cell-mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross-talk among T and NK cells in human tuberculous pleurisy. We found that endogenously activated pleural fluidderived NK cells express high ICAM-1 levels and induce T-cell activation ex vivo through ICAM-1. Besides, upon in vitro stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM-1 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti-ICAM-1 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cellcontact-dependent mechanism in the context of Mycobacterium tuberculosis infection.Key words: ICAM-1 . NK cells . Pleurisy . Th1 . Tuberculosis Supporting Information available online IntroductionPleuritis is the most frequent clinical manifestation of extrapulmonary tuberculosis (TB) among young adults, and is normally considered a relatively benign form of disease since it may resolve without chemotherapy [1]. Tuberculous pleurisy is caused by a severe delayed-type hypersensitivity reaction in response to the rupture of a subpleural focus of Mycobacterium tuberculosis (Mtb) infection, but it may also be developed as a complication of primary pulmonary TB [2,3]. This pleural effusion is characterized by a strong granulomatous inflammatory response to Mtb together with high levels of . NK cells are CD56 1 CD16 1/À /CD3 À CD19 À lymphocytes of the innate immune system whose function is controlled by an array of germline-encoded activator/inhibitory receptors [5,6]. Two subsets of NK cells have been identified in humans according to CD56 expression differing in phenotype and function, and also in terms of chemokine receptors and adhesion molecules expression [7,8,9]. Functionally, CD56 bright cells are effective cytokine producers, whereas CD56 dim cells are efficient effectors of natural and Ab-dependent target cell lysis. Recently, we have described that an endogenously activated pleural fluid NK (PF-NK) population is a major source of IFN-g in response to Mtb [10,11]. Consistently, PF-NK are enriched in CD56 bright cells, as has been observed in other chronic inflammatory sites [12,13] or in tumor-affected tissues [14]. Together with the classical NK functions (i.e. cytotoxicity and cytokine production), novel skills have recently been described in niche-specific and in vitro-activated human NK cells. These unconventional capabilities include [16,17,18] and direct pathogen recognition [19,20]. In this regard, a novel innate immune cell population called Interferon-producing killer dendritic cells has been recently described in mice [21,22].ICAM-1/CD54 is the major ligand of costimulatory a L b 2 integrin (CD11a/CD18), commonly known as lymphocyte function-associated antigen (LFA-1) [23,24]. The surface enhancement of ICAM-1 on endothelial, APC and...

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“…Despite the presence of overlapping bands, probably due to heterogeneity of glycans present on individual glycoproteins, multiple glycoproteins were identified, including the dendritic and epithelial cell receptor DEC-205 (CD205) and intercellular adhesion molecule 1 (ICAM-1) (Figure 3 and Additional file 1). DEC-205 and ICAM-1 are both heavily glycosylated proteins known to be expressed in HRS cells [13,14]. The heavy chain of the cell surface molecule CD98 (CD98hc) was identified across a region of the gel between approximately 75 and 100 kDa and the accompanying small chain LAT1 was also detected, but below confidence levels for the analysis (Additional file 1).…”

Section: Resultsmentioning

confidence: 99%

Glycoproteomic characterization of carriers of the CD15/Lewisx epitope on Hodgkin's Reed-Sternberg cells

et al. 2011

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BackgroundThe Lewisx trisaccharide, also referred to as the CD15 antigen, is a diagnostic marker used to distinguish Hodgkin's lymphoma from other lymphocytic cancers. However, the role of such fucosylated structures remains poorly understood, in part because carriers of Lewisx structures on Hodgkin's Reed-Sternberg cells have not been identified.MethodsGalMBP, an engineered carbohydrate-recognition protein that binds selectively to oligosaccharides with paired terminal galactose and fucose residues, has been used in conjunction with proteomic and glycomic analysis to identify glycoprotein carriers of Lewisx and related glycan structures in multiple Hodgkin's Reed-Sternberg cell lines.ResultsMultiple glycoproteins that bind to GalMBP and carry CD15/Lewisx have been identified in a panel of six Reed-Sternberg cell lines. The most commonly identified Lewisx-bearing glycoproteins are CD98hc, which was found in all six cell lines tested, and intercellular adhesion molecule-1 and DEC-205, which were detected in five and four of the lines, respectively. Thus, several of the most prominent cell adhesion molecules on the lymphomas carry this characteristic glycan epitope. In addition, the Hodgkin's Reed-Sternberg cell lines can be grouped into subsets based on the presence or absence of less common Lewisx-bearing glycoproteins.ConclusionsCD98 and intercellular adhesion molecule-1 are major carriers of CD15/Lewisx on Reed-Sternberg cells. Binding of DC-SIGN and other glycan-specific receptors to the Lewisx epitopes on CD98 and intercellular adhesion molecule-1 may facilitate interaction of the lymphoma cells with lymphocytes and myeloid cells in lymph nodes.

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Retracted: Transactivation of the ICAM‐1 gene by CD30 in Hodgkin's lymphoma

Cited by 6 publications

References 51 publications

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

NK cells from tuberculous pleurisy express high ICAM‐1 levels and exert stimulatory effect on local T cells

Glycoproteomic characterization of carriers of the CD15/Lewisx epitope on Hodgkin's Reed-Sternberg cells

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