Functional benefits of citrus fruits in the management of diabetes

Aruoma, Okezie I.; Landes, Bernie; Ramful-Baboolall, Deena; Bourdon, Emmanuel; Neergheen-Bhujun, Vidushi S.; Wagner, Karl‐Heinz; Bahorun, Theeshan

doi:10.1016/j.ypmed.2012.02.012

Cited by 83 publications

(53 citation statements)

References 33 publications

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“…flavanones, flavones and flavonols (in low concentration) and anthocyanidins (only in blood oranges) (Fig. 3) (Aruoma et al, 2012;Benavente-Garcia & Castillo, 2008;Khan & Dangles, 2014;Tripoli, Guardia, Giammanco, Majo, & Giammanco, 2007). Flavanones, naturally present as diglycosidic forms, are the most abundant citrus flavonoids which provide them their typical sour taste.…”

Section: Citrus Flavonoidsmentioning

confidence: 99%

“…Citrus flavanones are present mostly in citrus albedo (white spongy inner portion of citrus peel) (e.g. naringin, neohesperidin, neoeriocitrin) while flavones and flavonols are present in flavedo (coloured peripheral part of peel) and juice sacs (Aruoma et al, 2012;Berhow, Tisserat, Kanes, & Vandercook, 1998). Seeds are rich in glycosylated flavanones e.g.…”

Section: Citrus Flavonoidsmentioning

confidence: 99%

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An insight into the role of citrus bioactives in modulation of colon cancer

Kaur

2015

Journal of Functional Foods

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Section: Citrus Flavonoidsmentioning

confidence: 99%

Section: Citrus Flavonoidsmentioning

confidence: 99%

An insight into the role of citrus bioactives in modulation of colon cancer

Kaur

2015

Journal of Functional Foods

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“…Its fruit is among the world's most economically important fruit crops consumed as both fresh products and processed juices. Its aromatic peels (rind) are used in several different ways, as are the blossoms (the flowers), leaves and wood of the tree (Kalim et al 2015;Aruoma et al 2012;Wang et al 2014). The draft genome sequencing and annotation project of C. sinensis were finished in recent years providing beneficial information to the researcher of this species (Wang et al 2014;Xu et al 2013a, b).…”

Section: Introductionmentioning

confidence: 99%

Systems biology study of transcriptional and post-transcriptional co-regulatory network sheds light on key regulators involved in important biological processes in Citrus sinensis

Khodadadi¹,

Mehrabi²,

Najafi

et al. 2017

Physiol Mol Biol Plants

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Transcriptional and post-transcriptional regulators including transcription regulator, transcription factor and miRNA are the main endogenous molecular elements which control complex cellular mechanisms such as development, growth and response to biotic and abiotic stresses in a coordinated manner in plants. Utilizing the most recent information on such relationships in a plant species, obtained from high-throughput experimental technologies and advanced computational tools, we can reconstruct its co-regulatory network which consequently sheds light on key regulators involved in its important biological processes. In this article, combined systems biology approaches such as mining the literatures, various databases and network reconstruction, analysis, and visualization tools were employed to infer and visualize the coregulatory relationships between miRNAs and transcriptional regulators in Citrus sinensis. Using computationally and experimentally verified miRNA-target interactions and constructed co-expression networks on array-based data, 10 coregulatory networks and 10 corresponding subgraphs include FFL motifs were obtained for 10 distinct tissues/conditions. Then PPI subnetworks were extracted for transcripts/genes included in mentioned subgraphs in order to the functional analysis of extracted coregulatory circuits. These proposed coregulatory connections shed light on precisely identifying C. sinensis metabolic pathways key switches, which are demanded for ultimate goals such as genome editing.

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“…They are well-known for their flavor, nutritional value and medicinal features. The medicinal activities for this genus are attributed to the presence of many medicinally active secondary metabolites such as essential oils (Caccioni et al, 1998;Lota et al, 2000Lota et al, , 2001Dugo and Di Giacomo, 2002;Sutthanont et al, 2010;Espina et al, 2010), flavonoids (Tripoli et al, 2007;Abeysinghe et al, 2007;Du and Chen, 2010), limonoids (Rouseff and Nagy, 1982;Jayaprakasha et al, 1997), furanocoumarins, sterols, carotenoids and alkaloids (Ladaniya, 2008;He et (Chutia et al, 2009;Espina et al, 2010;Sultana et al, 2012;Tao et al, 2014), antioxidant (Goulas and Manganaris, 2011;Barros et al, 2012;Zhang et al, 2014), anti-inflammatory (Menichini et al, 2011), anticancer (Manthey and Guthrie, 2002;Benavente-Garcia and Castillo, 2008), antiproliferative (Du and Chen, 2010), anti-pulmonary fibrosis (Zhou et al, 2013), hypoglycemic (Aruoma et al, 2012) and insecticidal (Jayaprakasha et al, 1997;Sutthanont et al, 2010) activities.…”

Section: Introductionmentioning

confidence: 99%

Citrus reticulata Blanco cv. Santra leaf and fruit peel: A common waste products, volatile oils composition and biological activities

Hamdan¹,

Mohamed²,

El-Shazly³

2016

J. Med. Plants Res.

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The components of essential oils from the leaf and fruit peel of Citrus reticulata Blanco cv. Santra (santra mandarin) cultivated in Egypt were explored qualitatively and quantitatively using GLC and GLC/MS and 131 components were identified and quantified. In the leaf oil, one hundred and nine (109) compounds were determined with sabinene (23.10%) and linalool (21.20%) as a major component. The total identified components in the fruit peel oil were sixty-four and limonene (79.64%) was the most abundant. Santra mandarin volatile components showed good anti-inflammatory activity represented by its effect on tumor necrosis factor-α and nitric oxide. Egyptian santra mandarin chemotype was distinguished as limonene for peel oil while sabinene/linalool was observed for leaf oil. This study could be the milestone for the reuse and recycling of Egyptian santra mandarin leaves and fruit peel as a common waste products. The study also suggests the use of these wastes for the production of more valuable pure compounds such as limonene, sabinene and linalool.

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Functional benefits of citrus fruits in the management of diabetes

Cited by 83 publications

References 33 publications

An insight into the role of citrus bioactives in modulation of colon cancer

An insight into the role of citrus bioactives in modulation of colon cancer

Systems biology study of transcriptional and post-transcriptional co-regulatory network sheds light on key regulators involved in important biological processes in Citrus sinensis

Citrus reticulata Blanco cv. Santra leaf and fruit peel: A common waste products, volatile oils composition and biological activities

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