An insight into the role of citrus bioactives in modulation of colon cancer

Kaur, Jasleen; Kaur, Gurpreet

doi:10.1016/j.jff.2014.12.043

Cited by 51 publications

(19 citation statements)

References 201 publications

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“…Newly isolated limonoids will be reported and a wide (but not exhaustive) overview on recent findings concerning limonoid bioactivity will be given. Further references focusing on limonoid biological activities may be found in several excellent previous reviews [1,15,[29][30][31][32][33][34][35][36]. Most of the references reviewed herein derive from Reaxys database.…”

Section: Complexity and Evolution Of Citrus Limonoid Researchmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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Section: Complexity and Evolution Of Citrus Limonoid Researchmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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“…Among other secondary plant metabolites, polyphenols are believed to contribute to the health protective effect of many food commodities. Therefore, they have even been named “vitamins of the 21st century” [ 180 ]. Yamanaka et al reported that guava ( Psidium guajava L.) leaf showed strong depression effect against Vibrio and Aeromonas species [ 181 ].…”

Section: Polyphenol Bioactive Ingredients In Other Plant Foodsmentioning

confidence: 99%

A Review of Polyphenolics in Oak Woods

Zhang

Jian

Duan

et al. 2015

IJMS

144

113

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Polyphenolics, which are ubiquitous in plants, currently are among the most studied phytochemicals because of their perceptible chemical properties and antioxidant activity. Oak barrels and their alternatives, which are widely used in winemaking nowadays, contribute polyphenolics to wines and are thought to play crucial roles in the development of wines during aging. This study summarizes the detailed information of polyphenolics in oak woods and their products by examining their structures and discussing their chemical reactions during wine aging. This paper evaluates the most recent developments in polyphenolic chemistry by summarizing their extraction, separation, and their identification by the use of chromatographic and spectral techniques. In addition, this paper also introduces polyphenol bioactive ingredients in other plant foods.

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“…In the past few decades, plant essential oils (EOs) have attracted a lot of interest due to their safety and pharmacological properties including bacteriostatic, free radical scavenging, anti-inflammatory, and inhibitory effects on malignant tumor cell proliferation [1][2][3][4]. Citrus Eos are the main aromatic by-products of the juice extraction industry and are widely used in food, cosmetics and pharmaceutical industry [5][6][7]. The annual global production of citrus EO is approximately 16,000 tons, and the cost is about $14,000/ton on the international market.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

et al. 2020

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Grapefruit essential oil has been proven to have wide range of bioactivities. However, bioactivity of its molecular distillate has not been well studied. In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify its chemical composition. The antimicrobial activity of the light phase oil was tested by filter paper diffusion method, and the anticancer activity was determined by the Cell Counting Kit-8 (CCK-8) assay. Twenty-four components were detected with a total relative content of 99.74%, including 97.48% of terpenes and 1.66% of oxygenated terpenes. The light phase oil had the best antimicrobial effect on Bacillus subtilis, followed by Escherichia coli, Staphylococcus aureus and Salmonellaty phimurium. DPPH and ABTS assays demonstrated that the light phase oil had good antioxidant activity. The CCK-8 assay of cell proliferation showed that the light phase oil had a good inhibitory effect on the proliferation of HepG2 liver cancer cells and HCT116 colon cancer cells.

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An insight into the role of citrus bioactives in modulation of colon cancer

Cited by 51 publications

References 201 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

A Review of Polyphenolics in Oak Woods

Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

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