Functional asymmetry in schizophrenic patients during auditory speech processing

Mohr, Bettina; Heim, Sabine; Pulvermüller, Friedemann; Rockstroh, Brigitte

doi:10.1016/s0920-9964(00)00183-3

Cited by 18 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the older group, 11 out of 20 target words were monosyllabic (e.g., Dorf = village, Mund = mouth), and nine disyllabic (e.g., Foto = photo, König = king). Their lemma-frequency varied between 216 and 1137 per one million words in the CELEX database (Baayen et al, 1995), thus being considered high-frequent (Mohr et al, 2001). The distractor set ( n = 60) included 39 two-syllable words (e.g., Fenster = window, Sommer = summer) and 21 three-syllable exemplars (e.g., Kartoffel = potato, Nachmittag = afternoon).…”

Section: Methodsmentioning

confidence: 99%

Competition for Cognitive Resources During Rapid Serial Processing: Changes Across Childhood

2011

View full text Add to dashboard Cite

The ability to direct cognitive resources to target objects despite distraction by competing information plays an important role for the development of mental aptitudes and skills. We examined developmental changes of this ability in a cross-sectional design, using the “attentional blink” (AB) paradigm. The AB is a pronounced impairment of T2 report, which occurs when a first (T1) and second target (T2) embedded in a rapid stimulus sequence are separated by at least one distractor and occur within 500 ms of each other. Two groups of children (6- to 7-year-olds and 10- to 11-year-olds; ns = 21 and 24, respectively) were asked to identify green targets in two AB tasks: one using non-linguistic symbols and the other letters or words. The temporal distance or stimulus-onset asynchrony (SOA) between T1 and T2 varied between no intervening distractor (Lag 1, 116-ms SOA) and up to 7 intervening distractors (Lag 8, 928-ms SOA). In the symbol task, younger children linearly increased T2 identification with increasing lag. Older children, however, displayed a hook-shaped pattern as typically seen in adults, with lowest identification reports in T2 symbols at the critical blink interval (Lag 2, 232-ms SOA), and a slight performance gain for the Lag 1 condition. In the verbal task, the older group again exhibited a prominent drop in T2 identification at Lag 2, whereas the younger group showed a more alleviated and temporally diffuse AB impairment. Taken together, this pattern of results suggests that the control of attention allocation and/or working memory consolidation of targets among distractors represents a cognitive skill that emerges during primary school age.

show abstract

Section: Methodsmentioning

confidence: 99%

Competition for Cognitive Resources During Rapid Serial Processing: Changes Across Childhood

2011

View full text Add to dashboard Cite

show abstract

“…The distinct pattern of right‐handedness and left hemisphere dominance for language is robust and consistent enough that atypical patterns of asymmetries are often considered a consequence of early developmental insult or genetic mutation, and thereby often linked to a variety of neurological and neurodevelopmental disorders. For instance, it has been fairly well established that atypical rightward patterns of neuroanatomical and functional asymmetries in the brain, particularly in the planum temporale, and increased incidences of left‐ or mixed‐handedness are associated with schizophrenia . Similar patterns of atypical functional and neuroanatomical asymmetries as well as handedness have been reported to be associated with autism, stuttering, specific language impairment, and other neurological conditions.…”

Section: Introductionmentioning

confidence: 96%

Behavioral and brain asymmetries in primates: a preliminary evaluation of two evolutionary hypotheses

Hopkins

Misiura

Pope

et al. 2015

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Contrary to many historical views, recent evidence suggest that species-level behavioral and brain asymmetries are evident in nonhuman species. Here, we briefly present evidence of behavioral, perceptual, cognitive, functional, and neuroanatomical asymmetries in nonhuman primates. In addition, we describe two historical accounts of the evolutionary origins of hemispheric specialization and present data from nonhuman primates that address these specific theories. Specifically, we first discuss the evidence of that genes play specific roles in determining left–right differences in anatomical and functional asymmetries in primates. We next consider and present data on the hypothesis that hemispheric specialization evolved as a by-product of increasing brain size relative to the size of the corpus callosum in different primate species. Lastly, we discuss some of the challenges in the study of hemispheric specialization in primates and offer some suggestions on how to advance the field.

show abstract

“…This structure interconnects left and right hemispheres, and plays a primary role in sensory, as well as high-level cognitive integration(Gazzaniga, 2000). Neuropsychological schizophrenia studies provide evidence of interhemispheric information transfer impairment(Coger and Serafetinides, 1990;Bruder et al, 1995;Mohr et al, 2001;Seymour et al, 1994;Gruzelier, 1999). Additional evidence regarding interhemispheric connectivity abnormalities comes from electrophysiological studies demonstrating differences in latency and coherence between patients with schizophrenia and healthy controls(Norman et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum

Kubicki

Styner

Bouix

et al. 2008

Schizophrenia Research

100

View full text Add to dashboard Cite

Background A reduction in interhemispheric connectivity is thought to contribute to the etiology of schizophrenia. Diffusion Tensor Imaging (DTI) measures the diffusion of water and can be used to describe the integrity of the corpus callosum white matter tracts, thereby providing information concerning possible interhemispheric connectivity abnormalities. Previous DTI studies in schizophrenia are inconsistent in reporting decreased Fractional Anisotropy (FA), a measure of anisotropic diffusion, within different portions of the corpus callosum. Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions. Methods DTI and structural MRI scans were obtained from 32 chronic schizophrenic subjects and 42 controls. Corpus callosum cross sectional area and its probabilistic subdivisions were determined automatically from structural MRI scans using a model based deformable contour segmentation. These subdivisions employ a previously generated probabilistic subdivision atlas, based on fiber tractography and anatomical lobe subdivision. The structural scan was then co-registered with the DTI scan and the anatomical corpus callosum subdivisions were propagated to the associated FA map. Results Results revealed decreased FA within parts of the corpus interconnecting frontal regions in schizophrenia compared with controls, but no significant changes for callosal fibers interconnecting parietal and temporo-occipital brain regions. In addition, integrity of the anterior corpus was statistically significantly correlated with negative as well as positive symptoms, while posterior measures correlated with positive symptoms only. Conclusions This study provides quantitative evidence for a reduction of interhemispheric brain connectivity in schizophrenia, involving corpus callosum, and further points to frontal connections as possibly disrupted in schizophrenia.

show abstract

Functional asymmetry in schizophrenic patients during auditory speech processing

Cited by 18 publications

References 33 publications

Competition for Cognitive Resources During Rapid Serial Processing: Changes Across Childhood

Competition for Cognitive Resources During Rapid Serial Processing: Changes Across Childhood

Behavioral and brain asymmetries in primates: a preliminary evaluation of two evolutionary hypotheses

Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum

Contact Info

Product

Resources

About