Functional assessment of skeletal muscle ventricles after pumping for up to four years in circulation

Thomas, Gregory A.; Hammond, Robert L.; Greer, Kevin; Lu, Huiren; Jarvis, Jonathan C.; Shortland, Adam P; Pullan, D. Mark; Salmons, Stanley; Stephenson, Larry W.

doi:10.1016/s0003-4975(00)01732-x

Cited by 27 publications

(28 citation statements)

References 23 publications

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“…Pericardium may be used to line the auxiliary ventricle, and the connection with the aorta made with a bifurcated conduit; partial ligation of the aorta between the limbs of the graft then generates obligatory flow through the SMV. Such SMVs have pumped in circulation in dogs for up to 4 years [21].…”

Section: Skeletal Muscle Ventriclementioning

confidence: 99%

Cardiac assistance from skeletal muscle: a reappraisal☆

Salmons

2009

European Journal of Cardio-Thoracic Surgery

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SummaryCardiac assistance from skeletal muscle offers an attractive surgical solution to the problem of end-stage heart failure, yet it is widely regarded as a failed approach. I argue here that this is an outdated assessment. Systematic progress has been made over the last 25 years in understanding the relevant basic science. In the light of these advances we should be reconsidering the place of skeletal muscle assist in the surgical armamentarium. #

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Section: Skeletal Muscle Ventriclementioning

confidence: 99%

Cardiac assistance from skeletal muscle: a reappraisal☆

Salmons

2009

European Journal of Cardio-Thoracic Surgery

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“…6 SMVs provide category 2 assist, and the hemodynamic performance of several configurations has been demonstrated. 5,[7][8][9][10] Previous SMV models have used linings made from synthetic materials, autologous pericardium, 11 or aortic homograft. 12 The current model includes a lining made from pulmonary artery homograft.…”

Section: Smv Designmentioning

confidence: 99%

“…The inherent elasticity of the pulmonary artery also serves to reduce the effective preload pressure on the muscle of the SMV wall. 13 Earlier SMV configurations 10,12,14 used an inflow and an outflow that required 2 vascular anastomoses. Blood circulated through the device in parallel with the systemic circulation.…”

Section: Smv Designmentioning

confidence: 99%

Counterpulsation From the Skeletal Muscle Ventricle and the Intraaortic Balloon Pump in the Normal and Failing Circulations

et al. 2006

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Background-The intra-aortic balloon pump (IABP) is the device that is in most common use to provide cardiovascular support. A skeletal muscle ventricle (SMV) was configured to produce counterpulsation in the thoracic aorta similar to that obtained with an IABP. The hemodynamic effects of an IABP and a SMV in the same animal and in both normal and failing circulations were assessed. Methods and Results-SMVs were connected to and IABPs were placed in the thoracic aorta of 12 anesthetized pigs.Hemodynamic parameters during the IABP-or the SMV-assisted beat were compared with those during the preassist beat. Acute heart failure was induced in 6 of the pigs by snaring the left anterior descending coronary artery (LAD). The hemodynamic effects of the IABP and the SMV were then reassessed. In the assisted cycles, SMV activation increased the mean aortic diastolic pressure (MADP) by 26.5Ϯ3.5%, the mean diastolic LAD flow by 48.4Ϯ7.2%, and endocardial viability ratio (EVR) by 31.6Ϯ3.8% (PϽ0.0001). In the same animals, IABP assist increased MADP by 19.8Ϯ2.3%, mean diastolic LAD flow by 37.2Ϯ3.9%, and EVR by 21.4Ϯ3.0% (PϽ0.0001). Under acute heart failure conditions, both SMV and IABP assist significantly increased MADP, mean diastolic LAD flow, and EVR. Conclusions-In both the normal and failing circulations, the SMV was an effective counterpulsator, providing cardiac assist that was at least equal to that available from an IABP. The SMV may therefore provide the proven benefits of an IABP in ambulant patients.

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“…SMVs and BMHs basically have two main limitations: firstly muscle damage after electrical muscle fiber transformation from a fast twitched into a slow twitched non-fatigue muscle and secondly thromboembolic complications from the blood contacting surface especially when a muscular blood pump works on demand. Former investigators developed sack-ventricles within circulation in dogs pumping up to 4 years [1][2][3][4][5]. …”

Section: Introductionmentioning

confidence: 99%