Functional and structural network changes related with cognition in semantic dementia longitudinally

Lin, Hai; Cui, Liang; Chen, Keliang; Han, Zaizhu; Guo, Qihao

doi:10.1002/hbm.26345

Cited by 4 publications

(1 citation statement)

References 54 publications

(76 reference statements)

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“…The area under the curve was calculated for each network metric across a sparsity threshold ranging from 0.05 to 0.40 with an interval of 0.01. 29 Furthermore, global and node properties were determined alongside the computation of detailed graph metrics. Detailed graph features are presented in Appendix S1 : Method 3.…”

Section: Methodsmentioning

confidence: 99%

Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Li,

Long,

Liu

et al. 2024

CNS Neurosci Ther

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PurposeTo investigate dynamic functional connectivity (dFC) within the cerebellar‐whole brain network and dynamic topological properties of the cerebellar network in obstructive sleep apnea (OSA) patients.MethodsSixty male patients and 60 male healthy controls were included. The sliding window method examined the fluctuations in cerebellum‐whole brain dFC and connection strength in OSA. Furthermore, graph theory metrics evaluated the dynamic topological properties of the cerebellar network. Additionally, hidden Markov modeling validated the robustness of the dFC. The correlations between the abovementioned measures and clinical assessments were assessed.ResultsTwo dynamic network states were characterized. State 2 exhibited a heightened frequency, longer fractional occupancy, and greater mean dwell time in OSA. The cerebellar networks and cerebrocerebellar dFC alterations were mainly located in the default mode network, frontoparietal network, somatomotor network, right cerebellar CrusI/II, and other networks. Global properties indicated aberrant cerebellar topology in OSA. Dynamic properties were correlated with clinical indicators primarily on emotion, cognition, and sleep.ConclusionAbnormal dFC in male OSA may indicate an imbalance between the integration and segregation of brain networks, concurrent with global topological alterations. Abnormal default mode network interactions with high‐order and low‐level cognitive networks, disrupting their coordination, may impair the regulation of cognitive, emotional, and sleep functions in OSA.

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Section: Methodsmentioning

confidence: 99%

Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Li,

Long,

Liu

et al. 2024

CNS Neurosci Ther

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Temporo‐frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross‐cohort comparison

Huang,

Hu,

Cui

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWhether brain functional connectivity (FC) is consistently disrupted in individuals with mild cognitive impairment (MCI) with isolated language impairment (ilMCI), and its potential to differentiate between MCI subtypes remains uncertain.METHODSCross‐sectional data from 404 participants in two cohorts (the Chinese Preclinical Alzheimer's Disease Study and the Alzheimer's Disease Neuroimaging Initiative) were analyzed, including neuropsychological tests, resting‐state functional magnetic resonance imaging (fMRI), cerebral amyloid positivity, and apolipoprotein E (APOE) status.RESULTSTemporo‐frontoparietal FC, particularly between the bilateral superior temporal pole and the left inferior frontal/supramarginal gyri, was consistently decreased in ilMCI compared to amnestic MCI (aMCI) and normal controls, which was correlated with semantic impairment. Using mean temporo‐frontoparietal FC as a classifier could improve accuracy in identifying ilMCI subgroups with positive cerebral amyloid deposition and APOE risk alleles.DISCUSSIONTemporal‐frontoparietal hypoconnectivity was observed in individuals with ilMCI, which may reflect semantic impairment and serve as a valuable biomarker to indicate potential mechanisms of underlying neuropathology.Highlights Temporo‐frontoparietal hypoconnectivity was observed in impaired language mild cognitive impairment (ilMCI). Temporo‐frontoparietal hypoconnectivity may reflect semantic impairment. Temporo‐frontoparietal functional connectivity can classify ilMCI subtypes.

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Functional and structural network changes related with cognition in semantic dementia longitudinally

Lin

Cui

Chen

et al. 2023

Human Brain Mapping

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Longitudinal changes in the white matter/functional brain networks of semantic dementia (SD), as well as their relations with cognition remain unclear. Using a graph‐theoretic method, we examined the neuroimaging (T1, diffusion tensor imaging, functional MRI) network properties and cognitive performance in processing semantic knowledge of general and six modalities (i.e., object form, color, motion, sound, manipulation and function) from 31 patients (at two time points with an interval of 2 years) and 20 controls (only at baseline). Partial correlation analyses were carried out to explore the relationships between the network changes and the declines of semantic performance. SD exhibited aberrant general and modality‐specific semantic impairment, and gradually worsened over time. Overall, the brain networks showed a decreased global and local efficiency in the functional network organization but a preserved structural network organization with a 2‐year follow‐up. With disease progression, both structural and functional alterations were found to be extended to the temporal and frontal lobes. The regional topological alteration in the left inferior temporal gyrus (ITG.L) was significantly correlated with general semantic processing. Meanwhile, the right superior temporal gyrus and right supplementary motor area were identified to be associated with color and motor‐related semantic attributes. SD manifested disrupted structural and functional network pattern longitudinally. We proposed a hub region (i.e., ITG.L) of semantic network and distributed modality‐specific semantic‐related regions. These findings support the hub‐and‐spoke semantic theory and provide targets for future therapy.

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Functional and structural network changes related with cognition in semantic dementia longitudinally

Cited by 4 publications

References 54 publications

Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea

Temporo‐frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross‐cohort comparison

Functional and structural network changes related with cognition in semantic dementia longitudinally

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