Functional and morphological alterations in small intestine mucosa of chronic alcoholics

Bhonchal, Sonia; Nain, C. K.; Prasad, Kaushal Kishor; Nada, Ritambhra; Sharma, Arun; Sinha, Saroj Kant; Singh, Kartar

doi:10.1111/j.1440-1746.2007.05080.x

Cited by 37 publications

(42 citation statements)

References 24 publications

(27 reference statements)

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“…These results suggest that chronical alcohol consumption could induce IEB disruption, which is consistent with previous studies (Banan, Choudhary, Zhang, Fields, & Keshavarzian, 1999;Zhang, Hu, Yuan, & Wu, 2009;Zhong et al, 2010). Although alcohol exposure can cause gut leakiness, as demonstrated by detection of intestinal barrier dysfunction, previous light-microscopy studies found that chronic alcohol exposure did not affect intestinal histology (Bhonchal et al, 2008). There was also no obvious difference in intestinal histology between the alcoholfed mice and the control mice in the present study.…”

Section: Discussionsupporting

confidence: 90%

Abnormal ultrastructure of intestinal epithelial barrier in mice with alcoholic steatohepatitis

Wang

et al. 2014

Alcohol

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Section: Discussionsupporting

confidence: 90%

Abnormal ultrastructure of intestinal epithelial barrier in mice with alcoholic steatohepatitis

Wang

et al. 2014

Alcohol

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“…Either loss of the epithelial cells or disruption of the tight junctions will lead to an increase in intestinal permeability. Clinical studies demonstrated that acute alcohol administration can cause apparent histopathological changes in the proximal part of the small intestine, whereas chronic alcohol consumption only induces minor histopathological changes (9,12,34). Our previous study (30) also showed that intestinal histopathological alterations, such as loss of epithelial cells at the top of the intestinal villi, were associated with acute alcohol intoxication-induced intestinal barrier disruption in mice (30).…”

Section: Discussionmentioning

confidence: 83%

The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction

Zhong

McClain²,

Cave

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

186

165

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Disruption of the intestinal barrier is a causal factor in the development of alcoholic endotoxemia and hepatitis. This study was undertaken to determine whether zinc deficiency is related to the deleterious effects of alcohol on the intestinal barrier. Mice were pair fed an alcohol or isocaloric liquid diet for 4 wk, and hepatitis was detected in association with elevated blood endotoxin level. Alcohol exposure significantly increased the permeability of the ileum but did not affect the barrier function of the duodenum or jejunum. Reduction of tight-junction proteins at the ileal epithelium was detected in alcohol-fed mice although alcohol exposure did not cause apparent histopathological changes. Alcohol exposure significantly reduced the ileal zinc concentration in association with accumulation of reactive oxygen species. Caco-2 cell culture demonstrated that alcohol exposure increases the intracellular free zinc because of oxidative stress. Zinc deprivation caused epithelial barrier disruption in association with disassembling of tight junction proteins in the Caco-2 monolayer cells. Furthermore, minor zinc deprivation exaggerated the deleterious effect of alcohol on the epithelial barrier. In conclusion, epithelial barrier dysfunction in the distal small intestine plays an important role in alcohol-induced gut leakiness, and zinc deficiency attributable to oxidative stress may interfere with the intestinal barrier function by a direct action on tight junction proteins or by sensitizing to the effects of alcohol.

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“…Kapszulaendoszkópián átesett májcirrhosisos betegek kétharmadában találtak gyulladásos nyálkahár-tya-eltéréseket [31]. Továbbá különféle morfológiai elváltozások is leírásra kerültek a vékonybélben, mint pél-dául részleges boholyatrophia, enyhe-közepes fokú lamina propria sejtes infi ltráció és intraepithelialis lymphocytaszaporulat [32]. A bélbarrier integritásának károsodásáért a nyálkahártya vérátáramlásának megvál-tozása, az oxidatív stressz, a megnövekedett proinfl ammatorikus citokinkoncentráció és a nitrogén-oxid felelő-sek elsősorban [33,34].…”

Section: Coeliakia Morbus Crohn Májcirrhosisunclassified

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

et al. 2016

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DebrecenAz intestinalis zsírsavkötő fehérje a zsírsavkötő fehérjék családjába tartozó, a vékony-és vastagbél enterocytáinak citoszoljában termelődő, kis molekulasúlyú fehérje. Az enterocytasejtek membránintegritásának megbomlását köve-tően megjelenik a szisztémás keringésben, és a vesék glomerularis szűrőjén keresztül kiválasztódik a vizeletbe. A szerzők akut és krónikus enterocytakárosodással járó gastrointestinalis kórképekben az intestinalis zsírsavkötő fehérje biomarkerként való használatával kapcsolatos vizsgálatokat tekintik át. Orv. Hetil., 2016, 157(2), 59-64.Kulcsszavak: intestinalis zsírsavkötő fehérje, nekrotizáló enterocolitis, akut mesenterialis ischaemia, coeliakia, gyulladásos bélbetegség, bakteriális transzlokáció Intestinal fatty acid binding protein: marker of enterocyte damage in acute and chronic gastroenterological diseasesIntestinal fatty acid binding protein, a small cytosolic protein abundantly present in mature enterocytes of small and large intestine, has proven to be a sensitive marker for damage to the intestinal epithelium. Upon cellular damage of the enterocyte, intestinal fatty acid binding protein is readily released into the systemic circulation, passes through the glomerular fi lter and can be detected in the urine. In this review, the authors review studies on the application of this protein as a biomarker in acute and chronic gastrointestinal diseases.

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Functional and morphological alterations in small intestine mucosa of chronic alcoholics

Abstract: The study brought out the changes in small bowel of chronic alcoholics having ALD at both cellular and subcellular levels which correlated significantly.

Cited by 37 publications

References 24 publications

Abnormal ultrastructure of intestinal epithelial barrier in mice with alcoholic steatohepatitis

Abnormal ultrastructure of intestinal epithelial barrier in mice with alcoholic steatohepatitis

The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

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