Functional and anatomical remodeling in human retinal detachment

Souza, Clairton F. de; Kalloniatis, Michael; Polkinghorne, Philip J; McGhee, Charles N J; Acosta, Mónica L.

doi:10.1016/j.exer.2012.02.009

Cited by 29 publications

(31 citation statements)

References 77 publications

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“…These ages precede Müller cell gliosis signified by increased immunoreactivity of GFAP, mostly evident at P18-30 (Strettoi et al, 2002Goel and Dhingra, 2012). Upregulation of GFAP and other intermediate proteins in astrocytes and Müller cells is a common finding in a range of retinal conditions associated with gliosis response (Ekstrom et al, 1988;Strettoi et al, 2002Strettoi et al, , 2003Lewis and Fisher, 2003;de Souza et al, 2012). The earlier change in amino acid levels in Müller cells suggest that altered amino acid homeostasis is an earlier indicator of impending glial dysfunction.…”

Section: Amino Acid Neurochemistrymentioning

confidence: 93%

“…Similar to other rodent retinas (Fletcher andKalloniatis, 1996, 1997a,b), the mouse retina displays distinct cellular location during development, identified using pattern recognition of amino acid labeling patterns (Chua, 2008;Kalloniatis et al, 2012). Soma size, dendritic disposition, and labeling intensity are also supportive components in cellular classification (Sun et al, 2007b).…”

Section: Immunocytochemical Analysismentioning

confidence: 95%

“…Functional changes of inner retinal neurons following photoreceptor loss have been reported secondary to inherited retinal dystrophies, light-induced photoreceptor death, and retinal detachment (Varela et al, 2003;Marc et al, 2007;Barhoum et al, 2008;Chua et al, 2009;de Souza et al, 2012;Jones et al, 2012;Lin et al, 2012). Although cone survival persists for several months (Lin et al, 2009), bipolar cell responses in rd1 mice (C3H mice) are affected as early as postnatal day 14 , suggesting there is postreceptoral dysfunction in the cone pathway from an early stage of degeneration.…”

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confidence: 97%

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Functional and neurochemical development in the normal and degenerating mouse retina

Gibson

Fletcher

Vingrys

et al. 2013

J of Comparative Neurology

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The rd1 mouse is a well-established animal model for human retinitis pigmentosa (RP). We used electroretinography (ERG) to evaluate retinal function and postembedding immunocytochemistry to determine the changes in cellular amino acid expression in the normal (C57Bl6) and degenerating mouse retina (rd1), as a function of age during development and the onset of degeneration. In the normal mouse retina, photoreceptoral and post-photoreceptoral ERG responses improved simultaneously from eye-opening until adult levels were achieved at approximately postnatal day (P) 30. Maturation of amino acid neurochemistry preceded the development of retinal function in the normal retina. Amino acid levels increased immediately from birth and reached stable levels by eye-opening. In contrast, in the rd1 mouse, both rod and cone pathway function rapidly reduced from eye-opening and by P21 became undetectable. Interestingly, at P18 cone responses were still comparable between the normal and degenerating retina. Before eye opening, the pattern of amino acid immunoreactivity in the rd1 retina was similar to the normal retina. Alterations in neurochemistry were observed after the onset of rod photoreceptor cell death. The most obvious change was the reduction in neurotransmitter immunoreactivity within the synaptic layers and some cell classes of the rd1 retina. Reduction of glutamine and glutamate was observed in Müller cells before established gliosis markers. Overall, these results suggest the rapid maturation of neurochemistry by eye opening followed by functional maturation by P30 in the normal retina. The dystrophic retina displays similar neurochemistry to control retina before eye opening but a subsequent decline. J. Comp. Neurol. 521:1251-1267, 2013

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Section: Amino Acid Neurochemistrymentioning

confidence: 93%

Section: Immunocytochemical Analysismentioning

confidence: 95%

mentioning

confidence: 97%

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Functional and neurochemical development in the normal and degenerating mouse retina

Gibson

Fletcher

Vingrys

et al. 2013

J of Comparative Neurology

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“…Pattern standard deviation values were also significantly higher in the PPV group, indicating a more localized reduction in sensitivity. In order to rule out any effect of the detachment and its extent on mean deviation values,we separately studied the preoperative attached and detached areas of the retina at least 9 months postoperatively [4,5,6,7]. …”

Section: Discussionmentioning

confidence: 99%

“…Changes regarding photoreceptor degeneration, loss of ganglion cell axons and subsequent degeneration of the ganglion cell layer, which may be spread beyond the border of the detached retina, have been documented in experimental models [2,3,4,5,6,7]. Furthermore, surgical manipulations [8,9], intraocular pressure (IOP) variation during surgery [10,11], toxic effect of C 3 F 8 [12] and retinal dehydration caused by air infusion during PPV [13,14,15,16,17] may have deleterious effects on neural tissue, presenting as visual field defects in cases of macular holes, treated by PPV and intraocular gas.…”

Section: Introductionmentioning

confidence: 99%

Scleral Buckling versus Vitrectomy for Retinal Detachment Repair: Comparison of Visual Fields and Nerve Fiber Layer Thickness

Koutsandrea

Kanakis²,

Papaconstantinou³

et al. 2015

Ophthalmologica

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Purpose: To compare visual field loss and retinal nerve fiber layer (RNFL) defects in cases of rhegmatogenous retinal detachment (RRD) treated with scleral buckle (SB) versus pars plana vitrectomy (PPV) and C₃F₈ injection. Methods: This was a prospective, comparative interventional study of 50 eyes with primary RRD, treated with PPV (25 eyes) or SB (25 eyes). All measurements took place at least 9 months following successful and uncomplicated surgical treatment. The visual field total deviation (TD) values for preoperative attached and detached areas were calculated and compared separately. The optic nerve head morphology was studied with Heidelberg retinal tomography (HRT), and the RNFL using spectral-domain optical coherence tomography. Results: The preoperative detached areas demonstrated more affected TD values (in dB) compared to the preoperative attached areas (-6.9 ± 5.2 vs. -4.3 ± 3.3 for the SB group and -9.6 ± 5.2 vs. -7.8 ± 5.1 for the PPV group; p = 0.001) in both groups. The preoperative attached areas of the SB group showed better TD values (calculated mean values) compared to the preoperative attached areas of the PPV group (-4.3 ± 3.3 vs. -7.8 ± 5.1, p = 0.007). The RNFL and HRT values showed no statistically significant difference between the two groups. Conclusions: It seems that the preoperative detached retina, despite successful reattachment, suffers permanent damage as a result of the detachment, irrespective of the method of treatment. In the PPV group, the postoperative functionality of the preoperative attached areas was detected to be worse compared to the postoperative functionality of the preoperative attached areas of the SB group. We postulate that this fact could be attributed to an additional traumatizing factor (possibly fluid-air exchange or gas injection) in patients with RRD treated with PPV.

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Pathogenesis, Histopathology, and Classification of PVR

Pastor

2022

Retinal Detachment Surgery and Proliferative Vitreoretinopathy

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Functional and anatomical remodeling in human retinal detachment

Cited by 29 publications

References 77 publications

Functional and neurochemical development in the normal and degenerating mouse retina

Functional and neurochemical development in the normal and degenerating mouse retina

Scleral Buckling versus Vitrectomy for Retinal Detachment Repair: Comparison of Visual Fields and Nerve Fiber Layer Thickness

Pathogenesis, Histopathology, and Classification of PVR

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