Scleral Buckling versus Vitrectomy for Retinal Detachment Repair: Comparison of Visual Fields and Nerve Fiber Layer Thickness

Koutsandrea, Chryssanthi; Kanakis, Menelaos; Papaconstantinou, Dimitris; Brοuzas, Dimitrios; Ladas, Ioannis; Petrou, Petros; Georgalas, Ilias

doi:10.1159/000439443

Cited by 11 publications

(25 citation statements)

References 28 publications

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“…Untreated RRD may lead to impairment or loss of vision, and recovery is unlikely (10). The human eye is made up of millions of non-renewable RPE cells organized into a single-cell layer (11).…”

Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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Rhegmatogenous retinal detachment (RRD) is a disorder of the eye that affects physical and mental health. Retinal pigment epithelium (RPE) is closely associated with RRD, and it is hypothesized that RPE-secreted inflammatory cytokines may induce early pathological changes of RRD and may participate in RPE proliferation and migration. The present study determined a role for interleukin (IL)‑10 as an RPE‑secreted immune regulatory factor that contributes to RRD. A rat RRD model was established and RPE cells were isolated and cultivated. RPE cells were randomly divided into four groups, three treated with different concentrations of IL‑10 (100, 50, and 20 mM) and one untreated. RPE cell proliferation was evaluated by MTT assay and the activity of caspase‑3 was also measured. RPE cell invasion was determined by Transwell assay. Vascular endothelial growth factor A (VEGF) expression was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting; IL‑1 and IL‑6 levels were measured by ELISA. IL‑10 treatment suppressed RPE cell proliferation and migration, promoted caspase‑3 activity, inhibited VEGF mRNA and protein expression, and downregulated the secretion of inflammatory cytokines IL‑1 and IL‑6 in RRD group compared with the untreated Model group. The aforementioned effects of IL‑10 became more evident with increasing IL‑10 concentration. IL‑10 suppressed inflammation, facilitated RPE cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression.

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Section: Introductionmentioning

confidence: 99%

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Zhao

Wang

2018

Mol Med Report

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“…Overall, our results seem to show that, with respect to SB surgery, vitrectomy may affect the GCL-IPL layer. Albeit, the macular GCL-IPL thinning in PPV eyes does not seem to significantly influence the final visual acuity, it may underpin a functional involvement at the level of retinal sensitivity as observed previously by static automated perimetry [20]. Thus, in this context, the prevention of ganglion cells' damage might be a good target for future neuroprotective therapies to improve visual function after RRD repair.…”

Section: Discussionmentioning

confidence: 67%

“…Overall, the results of the present study suggest that GCL-IPL thinning is a direct result of PPV surgery. In a previous prospective study, Koutsandra et al evaluated visual field defects in RD cases treated with SB versus PPV and gas injection, they found that after surgery the retinal functionality of the preoperative attached areas was worse in the PPV group compared to the SB group [20]. In agreement with this study, we postulate that, since RD primarily affect the photoreceptor layer, the GCL-IPL thinning found in our cases treated with PPV may be related to minor additional traumatizing factors related to PPV itself.…”

Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer Thickness after Macula-Off Rhegmatogenous Retinal Detachment Repair: Scleral Buckling versus Pars Plana Vitrectomy

Gharbiya

Albanese

Plateroti

et al. 2020

JCM

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(1) Background: We evaluated macular ganglion cell layer–inner plexiform layer (GCL-IPL) thickness in patients with primary macula-off rhegmatogenous retinal detachment (RRD) treated with scleral buckling (SB) or pars plana vitrectomy (PPV) using spectral domain optical coherence tomography (SD-OCT). (2) Methods: In this retrospective, observational study, we reviewed the medical records of patients undergoing SB or PPV surgery for macula-off RRD. SD-OCT was performed at three and 12 months after surgery. The central and parafoveal GCL-IPL thicknesses in treated eyes were compared with those of healthy fellow eyes. OCT measurements between the SB and PPV group were also compared using the analysis of covariance. (3) Results: Seventy-one eyes of 71 patients with a mean age of 61.2 ± 11.7 years were included. The parafoveal GCL-IPL thickness of the PPV group was significantly reduced, with respect to fellow eyes, at three and 12 months (p < 0.01). After adjusting for age, axial length, spherical equivalent, RD extent, preoperative intraretinal cysts, duration of symptoms and postoperative IOP, the parafoveal GCL-IPL thickness in the PPV group was significantly reduced with respect to the SB group, both at three and 12 months (F = 11.45, p = 0.001 and F = 12.37, p = 0.001, respectively). (4) Conclusions: In conclusion, the GCL-IPL is reduced in thickness in eyes with macula-off RRD treated with vitrectomy and is significantly thinner compared to eyes undergoing scleral buckling surgery.

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“…This phenomenon is explained by some studies through the potential retinal trauma experienced during PPV because of the liquid-air or gas change (30).…”

Section: Discussionmentioning

confidence: 99%

Minimal Surgery Technique in Rhegmatogenous Retinal Detachment

Joshi

Öztürk

2018

ijmsci

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Abstract:Objectives: The aim of our study is to emphasize that, using minimal detachment surgery in selected cases among patients diagnosed with rhegmatogenous retinal detachment, it is possible to repair the detachment with scleral buckling + cryopexy without the drainage of subretinal fluid and to minimize invasive surgery. Methods: Minimally possible detachment surgery and conventional detachment surgery were applied to 50 eyes of 50 patients between 12 and 69 years old (28 males, 22 females) who were admitted to Şişli Etfal Hospital Eye Clinic Retina Unit and diagnosed with rhegmatogenous retinal detachment, and the data were divided into two groups and analyzed retrospectively. Preoperatively, anamnesis was obtained, visual acuity was measured, biomicroscopic examination was performed, intraocular pressure was measured, detailed fundus examination was performed and the topographical drawing of fundus oculi was made. All operations were performed under local anesthesia, and in the operating room. Results: In the 1st group, minimally invasive detachment surgery was performed on 30 eyes of 30 patients. This group of patients was followed up for a minimum of 5 months and a maximum of 2 years. In these cases, the anatomical success rate was 93.3%, and the visual success rate was 80%. In the 2nd Group, conventional detachment surgery was performed on 20 eyes of 20 patients. This group of patients was followed up for a minimum of 4 months and a maximum of 1.5 years. In these cases, the anatomical success rate is 60%, and the visual success rate is 60%. Conclusion: If patients with rhegmatogenous retinal detachment apply to an ophthalmologist in a timely fashion, very good anatomical and visual success rates can be achieved with the minimally invasive surgical technique. In conditions where vitreoretinal surgery is not possible in the appropriate patient group, the first option should be minimally invasive surgical technique.

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Scleral Buckling versus Vitrectomy for Retinal Detachment Repair: Comparison of Visual Fields and Nerve Fiber Layer Thickness

Cited by 11 publications

References 28 publications

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment

Macular Ganglion Cell Layer Thickness after Macula-Off Rhegmatogenous Retinal Detachment Repair: Scleral Buckling versus Pars Plana Vitrectomy

Minimal Surgery Technique in Rhegmatogenous Retinal Detachment

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