“…This finding is potentially relevant to understanding smoking patterns in schizophrenia. In schizophrenia, hypofrontality is perhaps the most frequently reported electrophysiological symptom (see Buchsbaum, 1990 for review), and impaired AS performance has been clearly demonstrated (Arolt et al, 1998;Crawford et al, 1995;Fukushima et al, 1988;Fukushima et al, 1990a;Fukushima et al, 1990b;Karoumi et al, 1998;Sereno and Holzman, 1995;Thacker et al, 1989). Furthermore, this population shows a much greater rate of cigarette smoking than the norm (deLeon, 1996;deLeon et al, 1995;Hughes et al, 1986;Lawrie et al, 1995;Lohr and Flynn, 1992;O'Farrell et al, 1983;Ziedonis et al, 1994).…”