Quantitative EEG in Schizophrenic Patients before and during Pharmacotherapy

Begić, Dražen; Hotujac, Ljubomir; Jokić‐Begić, Nataša

doi:10.1159/000026650

Cited by 19 publications

(11 citation statements)

References 28 publications

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“…Altered theta activity in schizophrenia has been documented irrespective of medication and duration of illness (Begic, Hotujac, & Jokic-Begic, 2000;Boutros, et al, 2008;Fehr et al, 2001). Medication with atypical neuroleptics (as predominatly administred in this patients group) may even lead to normalisation of the observed theta response (Czobor & Volavka, 1993).…”

Section: Limitations Of the Studymentioning

confidence: 79%

Theta response in schizophrenia is indifferent to perceptual illusion

Mathes

Schmiedt-Fehr

Kedilaya

et al. 2016

Clinical Neurophysiology

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Section: Limitations Of the Studymentioning

confidence: 79%

Theta response in schizophrenia is indifferent to perceptual illusion

Mathes

Schmiedt-Fehr

Kedilaya

et al. 2016

Clinical Neurophysiology

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“…Delta power is shown to decrease with initiation of pharmacotherapy. 63 Further, lower delta power has been shown to be associated with better treatment response. 56 The results of our study which link higher delta power with negative symptoms may suggest an expected poorer treatment response in such patients.…”

Section: Figure 2 Delta Power: Schizophrenia Patients Versus Healthymentioning

confidence: 99%

EEG Power Spectra Differentiate Positive and Negative Subgroups in Neuroleptic-Naive Schizophrenia Patients

John

Rangaswamy²,

Thennarasu³

et al. 2009

JNP

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Electroencephalogram spectral power was estimated at 30 scalp locations in 28 neuroleptic-naive, recent-onset schizophrenia (NRS) patients and 25 healthy comparison subjects in the resting eyes closed condition. Weighted relative power values in the various bandwidths were initially compared between NRS subjects and comparison subjects and subsequently between the positive symptom subgroup, negative symptom subgroup, and comparison subjects, to look for characteristic spectral power profiles of the homogeneous symptom subgroups. Significant differences were noted especially in alpha2, delta, and theta bands between NRS patients and healthy comparison subjects, while the positive symptom and negative symptom subgroups showed characteristic spectral power profiles in alpha1, alpha2, delta, and theta bands.

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“…Similarly, clozapine treatment led to a background slowing (i.e., shift towards lower frequencies) in the theta range, and often also in the delta range [Malow et al, 1994]. In fact, what seems to be a common feature of neuroleptic drugs is a reduction of spectral activity in the slow frequencies and an increase of spectral activity in the alpha frequencies [Begic et al, 2000b].…”

Section: Discussionmentioning

confidence: 99%

Nongenetic pathologic developments of brain‐wave patterns in monozygotic twins discordant and concordant for schizophrenia

Weisbrod

Hill

Sauer

et al. 2003

American J of Med Genetics Pt B

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Evidence from previous studies has suggested that the inter-individual differences in human brain-wave patterns (EEG) are predominantly determined by genetic factors. In particular, the within-pair EEG concordance of monozygotic (mz) twins was found to be typically as high as r = 0.81 across channels and frequency bands, thus being comparable to that between repeated assessments on the same individual with typically r = 0.83. Yet our investigations into mz twins discordant and concordant for schizophrenia yielded a significantly reduced within-pair EEG concordance for both, the pairs discordant for schizophrenia and the pairs concordant for schizophrenia (with concordance for schizophrenia assessed through a syndrome-oriented approach). A multivariate discriminant function of EEG parameters distinguished in a reproducible way between affected and unaffected subjects at an overall performance of >75% correctly classified subjects, while the severity of illness, as derived from EEG-differences between affected and unaffected subjects, was closely related to the severity of illness as provided by psychopathology syndrome scores. Consequently, EEG anomalies associated with schizophrenia and manifested differently in the mz co-twins concordant for schizophrenia are likely the effect of nongenetic, pathologic processes that evolved independently in the co-twins' genetically identical brains once the illness began to progress. The existence of such nongenetic processes would suggest a modification of the standard phenotype-to-genotype search strategies of molecular-genetic studies that aim to link the schizophrenia phenotype to genetic vulnerability factors.

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Quantitative EEG in Schizophrenic Patients before and during Pharmacotherapy

Cited by 19 publications

References 28 publications

Theta response in schizophrenia is indifferent to perceptual illusion

Theta response in schizophrenia is indifferent to perceptual illusion

EEG Power Spectra Differentiate Positive and Negative Subgroups in Neuroleptic-Naive Schizophrenia Patients

Nongenetic pathologic developments of brain‐wave patterns in monozygotic twins discordant and concordant for schizophrenia

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