Functional analysis of T lymphocytes infiltrating the dermis and epidermis of post-burn hypertrophic scar tissues

Bernabei, Paola; Rigamonti, L; Ariotti, Silvia; Stella, Maurizio; Castagnoli, Carlotta; Novelli, Francesco

doi:10.1016/s0305-4179(98)00128-4

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…This is well in line with previous limited analyses 5,16–18 . A similar association with prominent T‐cell infiltrates, both Th1 and Th2, was previously reported in HTS, during active and remission phases, respectively 10,11,44 . Furthermore, increased T cell‐mediated TGF‐β production 12,13 and compromised HTS growth in T cell‐deprived mice under mechanical tension 15 support a role for T cells in HTS pathogenesis.…”

Section: Discussionsupporting

confidence: 89%

“…5,[16][17][18] A similar association with prominent T-cell infiltrates, both Th1 and Th2, was previously reported in HTS, during active and remission phases, respectively. 10,11,44 Furthermore, increased T cell-mediated TGF-b production 12,13 and compromised HTS growth in T cell-deprived mice under mechanical tension 15 support a role for T cells in HTS pathogenesis. Thus, it is reasonable to speculate that the HTS-promoting function of T cells is further extenuated in KD, which may contribute to the prolonged fibroproliferative response in KD.…”

Section: Discussionmentioning

confidence: 87%

“…Keloid disease shares several pathobiological features, such as inflammation and excessive collagen synthesis, with other fibrotic diseases such as hypertrophic scars (HTS) and scleroderma 5–8 . Inflammatory cells have been shown to play a fundamental role in fibrosis associated with wound healing, HTS and scleroderma 5,9–16 . For example, T cell‐derived transforming growth factor (TGF)‐β in HTS can induce increased collagen synthesis, fibroblast proliferation and myofibroblast differentiation, 12,13 at least during the active phase of the fibroproliferative process 12 .…”

mentioning

confidence: 99%

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Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

Bagabir

Byers

Chaudhry

et al. 2012

British Journal of Dermatology

111

123

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

See 1 more Smart Citation

Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

Bagabir

Byers

Chaudhry

et al. 2012

British Journal of Dermatology

111

123

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“…T-cells in the wound are predominantly of a Th-1 type phenotype [47]. Bernabei et al [48] observed that active hypertrophic scar tissue was infiltrated by Th1-type T-cells, whereas the Th2-type phenotype was characteristic of the remission phase of hypertrophic scar formation.…”

Section: γδ T-cells and Wound Healingmentioning

confidence: 99%

γδ T-cells: Potential regulators of the post-burn inflammatory response

Schwacha¹

2009

Burns

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Burn injury induces an immunopathological response that can contribute to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, γδ T-cells are central in the response to injury. While γδ T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn injury. This review will focus on the potential regulator role of γδ T-cells in immunopathological response following burn injury and thereby their potential as therapeutic targets for modulation of post-burn inflammation and healing.

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“…Like keloids, HS have a definite immune response trait with characteristic immune cell infiltration comprising primarily of T cells along with macrophages and Langerhans'cells (30,71,72) in conjunction with ectopic expression of HLA class II molecules (30,56) and pro-inflammatory cytokines (30,73) (Fig. 4).…”

Section: Human Leukocyte Antigen and Hypertrophie Scarsmentioning

confidence: 99%

Influence of the Human Leukocyte Antigen Complex on the Development of Cutaneous Fibrosis: An Immunogenetic Perspective

McCarty¹,

Syed²,

Bayat³

2010

Acta Derm Venerol

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A number of aesthetically and physically distressing disorders of the skin come under the general term "cutaneous fibrosis", all sharing a common abnormal wound healing process. These disorders are often incurable and effective treatments remain to be established and, as such, they present a significant burden for patients and a therapeutic challenge for clinicians. The aim of this review is to investigate the evidence of either positive or negative associations of the human leukocyte antigen (HLA) system with various types of cutaneous fibrosis, focussing in particular on keloid scars, hypertrophic scars and scleroderma. A standard systematic literature search was performed. The strengths and limitations of studies were evaluated in terms of significance, methodology and reproducibility. There is a clear association between specific HLA alleles and predilection or protection to cutaneous fibrosis. Of these candidate HLA alleles, the class II loci seem to be the most promising in terms of a genetic biomarker, with the DQ and DR alleles having significant associations with abnormal wound healing and cutaneous fibrosis. There is strong evidence of a significant immune component in the pathogenesis of each type of fibrotic disorder explored in this review. However, the exact mechanisms remain to be elucidated, since the pathogenesis of cutaneous fibrosis and abnormal wound healing are not fully understood.

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Functional analysis of T lymphocytes infiltrating the dermis and epidermis of post-burn hypertrophic scar tissues

Cited by 25 publications

References 22 publications

Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

γδ T-cells: Potential regulators of the post-burn inflammatory response

Influence of the Human Leukocyte Antigen Complex on the Development of Cutaneous Fibrosis: An Immunogenetic Perspective

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