Functional Analysis in Single-Lung Transplant Recipients

Zaporozhan, J.; Ley, Sebastian; Gast, Klaus; Schmiedeskamp, Jörg; Biedermann, Alexander; Eberle, Balthasar; Kauczor, Hans‐Ulrich

doi:10.1378/chest.125.1.173

Cited by 53 publications

(21 citation statements)

References 26 publications

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“…33 Therefore, no ADC values can be measured in these areas (Fig. 1B) because the signal intensity in the diffusion weighted image is too low to calculate an ADC value.…”

Section: Discussionmentioning

confidence: 99%

Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Ley

Zaporozhan²,

Morbach³

et al. 2004

Investigative Radiology

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“…33 Therefore, no ADC values can be measured in these areas (Fig. 1B) because the signal intensity in the diffusion weighted image is too low to calculate an ADC value.…”

Section: Discussionmentioning

confidence: 99%

Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Ley

Zaporozhan²,

Morbach³

et al. 2004

Investigative Radiology

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“…In healthy smokers with normal lung function even subtle ventilation defects were visualized, demonstrating the high sensitivity of the technique [60]. Volume of ventilated lung areas on 3 He-MRI correlated well with vital capacity (r=0.9) and the amount of non-emphysematous volume on CT (r=0.7) in patients with severe emphysema following single lung transplantation [61]. Quantification of ventilatory impairment can be achieved by automatic segmentation of the lung allowing for precise pre-and post-therapeutic comparison of ventilation [62].…”

Section: Mrimentioning

confidence: 85%

Morphological and functional imaging in COPD with CT and MRI: present and future

2007

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway collapse), the parenchyma (i.e. hyperinflation, air trapping and emphysematous destruction) as well as the vasculature (i.e. hypoxic vasoconstriction, rarefication and pulmonary arterial hypertension) with different severity during the course of the disease. These different aspects of COPD can be best addressed by imaging using a combination of morphological and functional techniques. Three-dimensional high-resolution computed tomography (3D-HRCT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about perfusion, regional lung mechanics, and ventilation mainly provided by MRI. The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization and dedicated therapy monitoring of COPD as presented in this review.

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“…Recently, others measured ventilated lung volumes using a hyperpolarized 3 He MRI scan, which showed a good correlation with nonemphysematous lung volume as measured by CT scan [16]. The investigators used it to determine split-lung volumes in single-lung transplant recipients, where standard pulmonary function tests are insufficient to assess the left-right distribution.…”

Section: Discussionmentioning

confidence: 99%

Alveolar Volume Determined by Single-Breath Helium Dilution Correlates with the High-Resolution Computed Tomography-Derived Nonemphysematous Lung Volume

Lee

Es²,

Noordmans³

et al. 2006

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Background: The alveolar volume (V_A), determined by single-breath helium dilution, is a measure for the total lung capacity (TLC) that is very sensitive to ventilatory disturbances. In chronic obstructive pulmonary disease (COPD), the emphysematous lung parts are less accessible to test gas; therefore, the V_A is smaller than TLC measured by multiple-breath helium dilution (TLC_He). Objectives: The aim of this study was to investigate whether the V_A represents the nonemphysematous lung parts. Methods: We measured V_A as part of the diffusing capacity for carbon monoxide (DL_CO), TLC_He and spirometry in 50 patients with COPD. High-resolution computed tomography (HRCT) scans of all subjects were analyzed with the density mask method, where parts with an attenuation of less than –950 Hounsfield units were considered as emphysematous. Results: A strong correlation was observed between the V_A (mean 5.2 liters) and nonemphysematous HRCT lung volume (mean 5.2 liters, r² = 0.9) and between the TLC_He (mean 6.6 liters) and total HRCT lung volume (mean 6.4 liters, r² = 0.9). Bland-Altman plots showed considerable disagreement between the V_A and the nonemphysematous HRCT lung volume. A weak correlation between the forced expiratory volume in 1 s (mean 46% predicted) and DL_CO (mean 46% predicted) versus the HRCT emphysema ratio (nonemphysematous/total HRCT lung volume) was observed (r² = 0.3 and 0.3, respectively). Conclusion: We concluded that the V_A correlates with the nonemphysematous HRCT lung volume, although the two measurements are not equivalent, possibly due to technical factors.

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Functional Analysis in Single-Lung Transplant Recipients

Cited by 53 publications

References 26 publications

Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Morphological and functional imaging in COPD with CT and MRI: present and future

Alveolar Volume Determined by Single-Breath Helium Dilution Correlates with the High-Resolution Computed Tomography-Derived Nonemphysematous Lung Volume

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