Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Ley, Sebastian; Zaporozhan, J.; Morbach, Andreas E.; Eberle, Balthasar; Gast, Klaus; Heußel, Claus Peter; Biedermann, Alexander; Mayer, Eckhard; Schmiedeskamp, Joerg; Stepniak, Andreas; Schreiber, Laura M.; Kauczor, Hans‐Ulrich

doi:10.1097/01.rli.0000129468.79005.1d

Cited by 57 publications

(35 citation statements)

References 28 publications

(47 reference statements)

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“…A comparison of healthy non-smokers and smokers demonstrated an increase in the mean ADC and heterogeneity in the smokers . Several studies (Kauczor et al 1996;Saam et al 2000;Ley et al 2004) have been performed on patient and animal models with varying degrees of severity of emphysema using ventilation distribution and ADC maps. There appears to be relatively good correlation between PFTs, CT, histology and ADC measurements, with hyperpolarized helium being more sensitive for disease detection than CT and PFTs (Salerno et al 2002;Peces-Barba et al 2003;Woods et al 2006;Tanoli et al 2007).…”

Section: (B ) Clinical Applicationsmentioning

confidence: 99%

“…This effect was first suggested by Chen et al (1999) and Saam et al (2000) and later derived by Yablonskiy et al (2002). Using different MRI pulse sequences, a range of measurements can be performed including spin density, dynamic ventilation, oxygen-sensitive imaging and diffusion-weighted (DW) imaging (Pineda et al 1984;Eberle et al 2000;Schreiber et al 2000;Kauczor et al 2002;Ley et al 2004). In this paper, we will focus on the latter technique, as it is the most relevant one to assess pulmonary airspaces at the levels of bronchioles and alveoli.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry

Plotkowiak

Burrowes

Wolber³

et al. 2009

Phil. Trans. R. Soc. A.

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Both the development of accurate models of lung function and their quantitative validation can be significantly enhanced by the use of functional imaging techniques. The advent of hyperpolarized noble gas magnetic resonance imaging (MRI ) technology has increased the amount of local, functional information we can obtain from the lung. In particular, application of 3 He to measure apparent diffusion coefficients has enabled some measure of lung microstructure and airspace size within the lung. Models mimicking image acquisition in hyperpolarized gas MRI can improve understanding of the relationship between image findings and lung structure, and can be used to improve the definition of imaging protocols. In this paper, we review the state of the art in hyperpolarized gas MRI modelling. We also present our own results, obtained using a Monte Carlo approach and a realistic alveolar sac geometry, which has previously been applied in functional lung studies. In this way, we demonstrate the potential for models combining lung function and image acquisition, which could provide valuable tools in both basic studies and clinical practice.

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Section: (B ) Clinical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry

Plotkowiak

Burrowes

Wolber³

et al. 2009

Phil. Trans. R. Soc. A.

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show abstract

“…In clinical studies, the regional measurement of 3He ADC values has been used to evaluate the severity of emphysema in patients [54][55][56]. This approach is supported by the good correlation observed between the 3He ADC values and alveolar dimensions [40].…”

Section: Clinical Applicationsmentioning

confidence: 81%

Functional MRI of the Lung

Berthezène

2010

TONMEDJ

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Abstract:Imaging of the pulmonary parenchyma represents a unique challenge for MRI. Limited signal is caused by low proton density, susceptibility artefacts, and physiological motion (cardiac pulsation, respiration). Improvements in MRI techniques have extended the potential for investigations of pulmonary parenchymal disease with the evaluation of lung perfusion. More recently inhalation of non proton-MRI nuclei such as hyperpolarized gases (3He or 129Xe) can provide functional ventilation images.

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“…Die einzige bildgebende Alternative ist die Dünn-schicht-CT mit anschließender Berechnung des Emphysemindex. Dementsprechend konnte auch eine gute Korrelation von r = 0,8 zwischen ADC und Emphysemindex aus der HRCT berechnet werden [61]. Da die CT das morphologische Substrat des Emphysems darstellt und der ADC-Wert auf dem ventilierten Anteil des Emphysems basiert, korreliert der ADC-Wert noch besser mit der forcierten exspiratorischen Einsenkundenkapazität (FEV 1 ; r = -0,93) [58].…”

Section: Abbildung 7 Histogramm Der Adc-werte Der 61-jährigen Lungenunclassified

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

Gast

Morbach²,

Kauczor

et al. 2005

Med Klin

Self Cite

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Lung imaging is traditionally done using X-ray-based methods, since MRI is limited by low proton density as well as inherent magnetic field inhomogeneities of the lung tissue. After introduction of MRI using hyperpolarized noble gases, a totally new field of MRI of the chest has rapidly evolved. These techniques reveal new functional information of the lungs, which could not be obtained before. The first part of this review describes the underlying MR technology explaining distribution of static ventilation, dynamic distribution of ventilation, lung microstructure (apparent diffusion coefficient [ADC]), measurement of oxygen partial pressure (pO(2)), and safety. The clinical potential is afterwards demonstrated in the second part. Therefore, the effort in normal lungs and the mainly focused diseases chronic obstructive pulmonary disease (COPD), smoker's lung, cystic fibrosis, asthma, lung transplantation, and pulmonary embolism are reported.

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Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests

Abstract: In this initial study, He-MRI yield good correlations with HRCT and agrees better than HRCT with the functional characterization of emphysema regarding hyperinflation, large and small airway disease as provided by LFT.

Cited by 57 publications

References 28 publications

Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry

Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry

Functional MRI of the Lung

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

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