Functional aliphatic polyesters for biomedical and pharmaceutical applications

Seyednejad, Hajar; Ghassemi, Amir H.; Nostrum, Cornelus F. van; Vermonden, Tina; Hennink, Wim E.

doi:10.1016/j.jconrel.2010.12.016

Cited by 370 publications

(318 citation statements)

References 92 publications

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“…However, the coagulation was at a rate that was more suited to a vertically oriented fiber spinning setup. In this setup, which we have reported previously [46,70,72] , the spinning solution is injected from the top and into a vertical glass column containing the IPA coagulation bath. As the spinning solution is extruded from the spinneret, the coagulation process occurs smoothly after which the gel fiber continues to solidify and is stretched by gravity.…”

Section: Wet-spinning Of Graphene-plga Biomimetic Fibersmentioning

confidence: 99%

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Esrafilzadeh

Jalili

Stewart

et al. 2016

Adv Funct Materials

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The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, it is demonstrated that with the aid of rheological insights, optimized formulations of graphene containing spinnable poly(lactic-co-glycolic acid) (PLGA) dopes can be made possible. This helps extend the general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solutionprocessed graphene into the design process and practical fiber architectural engineering. The as-produced fibers are found to exhibit excellent electrical conductivity and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt%), the conductivity of as-prepared fibers is as high as 150 S m-1 (more than two orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber are enhanced 647-and 59-folds, respectively, through addition of graphene. Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsEsrafilzadeh, D., Jalili, R., Stewart, E. M., Aboutalebi, S. H., Razal, J. M., Moulton, S. The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, we demonstrate that with the aid of rheological insights, optimized formulations of graphene 2 containing spinnable Poly Lactic-co-Glycolic Acid (PLGA) dopes can be made possible. This helps us extend our general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solution-processed graphene into the design process and practical fiber architectural engineering. The asproduced fibers were found to exhibit excellent electrical conductivity, and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt. %), the conductivity of as-prepared fibers was as high as 150 S m −1 (more than 2 orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber were enhanced 647-and 59-folds, respectively, through addition of graphene.

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Section: Wet-spinning Of Graphene-plga Biomimetic Fibersmentioning

confidence: 99%

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Esrafilzadeh

Jalili

Stewart

et al. 2016

Adv Funct Materials

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“…Applications range from materials for solving "white pollution concerns" caused by non-degradable polymers to materials with good properties to fulfil, for example, the highly restrictive requirements of the biomedical field [1][2][3]. The most common polyesters are prepared by ring-opening polymerization of lactones (e.g., polyglycolide, polylactide, and poly(ε-caprolactone)) [4,5], but the production of poly(alkylene dicarboxylate)s has attracted a great deal of attention as well, especially for commodity applications [6].…”

Section: Introductionmentioning

confidence: 99%

“…HAp (Ca 10 (PO 4 ) 6 (OH) 2 ) is a bioceramic that forms part of the majority of the inorganic components of hard and connective tissues such as bones, teeth, and tendons. Nowadays, development of Hap-based nanocomposites and biodegradable polymers is attracting increasing interest since the presence of hydroxyl groups in the added nanoparticles may enhance polymer degradation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxyapatite Nanoparticles on the Degradability of Random Poly(butylene terephthalate-co-aliphatic dicarboxylate)s Having a High Content of Terephthalic Units

et al. 2016

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Copolyesters derived from 1,4-butanediol and constituted also of aliphatic and aromatic dicarboxylate units in a molar ratio of 3:7 were synthesized by a two-step polycondensation procedure. Succinic, adipic, and sebacic acids were specifically selected as the aliphatic component whereas terephthalic acid was chosen as the aromatic moiety. The second synthesis step was a thermal transesterification between the corresponding homopolymers, always attaining a random distribution as verified by NMR spectroscopy. Hybrid polymer composites containing 2.5 wt % of hydroxyapatite (HAp) were also prepared by in situ polymerization. Hydroxyl groups on the nanoparticle surface allowed the grafting of polymer chains in such a way that composites were mostly insoluble in the typical solvents of the parent copolyesters. HAp had some influence on crystallization from the melt, thermal stability, and mechanical properties. HAp also improved the biocompatibility of samples due to the presence of Ca 2+ cations and the damping effect of phosphate groups. Interestingly, HAp resulted in a significant increase in the hydrophilicity of samples, which considerably affected both enzymatic and hydrolytic degradability. Slight differences were also found in the function of the dicarboxylic component, as the lowest degradation rates was found for the sample constituted of the most hydrophobic sebacic acid units.

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“…In recent years, there has been a renewed interest in polyesters as drug delivery devices due to their favorable biocompatibility and controllable biodegradation profiles [1][2][3][4]. Accordingly, polyester materials are regarded as a material of choice for biomedical applications including drug delivery [5][6][7][8][9], as diagnostic agents [10,11] and for tissue engineering [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…More recently, there has been a strong economic and ecological drive for polymer precursors to be derived from sustainable building blocks, and for polymers to be produced with minimal use of solvents [19]. The synthesis of polyesters for drug delivery has been very thoroughly explored, with many variations around the use of poly(lactides), poly(caprolactone) and poly(carbonates) [3,20,21]. However, these polyesters by themselves are not easy to formulate into nanoparticles that are stable for storage in solution or for intravenous injection.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers

Kakde

Powell

Bansal

et al. 2016

Journal of Controlled Release

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Functional aliphatic polyesters for biomedical and pharmaceutical applications

Cited by 370 publications

References 92 publications

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Effect of Hydroxyapatite Nanoparticles on the Degradability of Random Poly(butylene terephthalate-co-aliphatic dicarboxylate)s Having a High Content of Terephthalic Units

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers

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