Functional Activity of Lymphocytes of Healthy Donors and Cancer Patients After Culturing with IL-2 and IL-15

Gelm, Yu. V.; Кузьмина, Е. Г.; Абакушина, Е. В.

doi:10.1007/s10517-019-04556-3

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The average diameter of lymphocytes is 7–15 µm. Lymphocytes are mainly found in the circulation and central lymphoid organs such as the spleen, tonsils, and lymph nodes (Gel’m et al., 2019 ). There are three main subtypes of lymphocytes, including T-cells, B-cells, and natural killer cells.…”

Section: Cells Used For Cell-mediated Drug Deliverymentioning

confidence: 99%

Cell-mediated targeting drugs delivery systems

Yang

et al. 2020

Drug Delivery

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Drug delivery systems have shown tremendous promise to improve the diagnostic and therapeutic effects of drugs due to their special property. Targeting tissue damage, tumors, or drugs with limited toxicity at the site of infection is the goal of successful pharmaceuticals. Targeted drug delivery has become significantly important in enhancing the pharmaceutical effects of drugs and reducing their side effects of therapeutics in the treatment of various disease conditions. Unfortunately, clinical translation of these targeted drug delivery system mechanisms faces many challenges. At present, only a few targeted drug delivery systems can achieve high targeting efficiency after intravenous injection, even though numerous surface markers and targeting approaches have been developed. Thus, cellmediated drug-delivery targeting systems have received considerable attention for their enhanced therapeutic specificity and efficacy in the treatment of the disease. This review highlights the recent advances in the design of the different types of cells that have been explored for cell-mediated drug delivery and targeting mechanisms. A better understanding of cell biology orientation and a new generation of delivery strategies that utilize these endogenous approaches are expected to provide better solutions for specific site delivery and further facilitate clinical translation.

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Section: Cells Used For Cell-mediated Drug Deliverymentioning

confidence: 99%

Cell-mediated targeting drugs delivery systems

Yang

et al. 2020

Drug Delivery

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Nano-engineered immune cells as “guided missiles” for cancer therapy

Zhang

Tai

Cui

et al. 2022

Journal of Controlled Release

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Activation of lymphocytes in vitro for immunotherapy of patients with melanoma

Абакушина

Gelm

Lyssuk

2021

Medicinskij alfavit

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This article describes a method for activating lymphocytes isolated from the peripheral blood of melanoma patients and cultured in a medium supplemented with IL‑2 and IL‑15. It was shown that in these terms, lymphocytes have an increased proliferative and activation potential. The combination of cytokines has a positive effect on cytotoxicity, viability and the expression of activation markers (CD38, CD69, CD25, HLA-DR and NKG2D) on NK- and T-lymphocyte, and may be recommended for the culture of lymphocytes in melanoma patients for the purpose of adoptive immunotherapy.

show abstract

Functional Activity of Lymphocytes of Healthy Donors and Cancer Patients After Culturing with IL-2 and IL-15

Cited by 3 publications

References 7 publications

Cell-mediated targeting drugs delivery systems

Cell-mediated targeting drugs delivery systems

Nano-engineered immune cells as “guided missiles” for cancer therapy

Activation of lymphocytes in vitro for immunotherapy of patients with melanoma

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