Function of the nephron and the formation of urine

Lawrence, Eloise; Doherty, Daniel T.; Dhanda, Raman

doi:10.1016/j.mpaic.2018.03.001

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The main structural and functional components of kidneys are nephrons, which consist of the glomerulus and Bowmans's capsule as well as renal tubules, including proximal convoluted tubule, loop of Henley and the distal convoluted tubule. 163 Blood enters the kidneys individual glomerular tuft through the afferent arteriole and exits via efferent arteriole. 164 As plasma flows through glomerular capillaries it is filtered to Bowmans capsule and enters the proximal tubule (PT) which is where molecule reabsorption occurs.…”

Section: Kidney Physiologymentioning

confidence: 99%

Regulation of Megalin and Clathrin-Mediated Endocytosis by Amp-Activated Protein Kinase

Leshchyshyn

2024

Preprint

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<p>AMP-activated protein kinase (AMPK) is a metabolic stress sensor, activated at low ATP levels. Our previous studies found AMPK activation reduced cell surface β1-integrin levels which are regulated by clathrin-mediated endocytosis (CME), an internalization mechanism dependent on adaptor proteins and triggered by cytosolic motif of a protein. This indicates that metabolic stress influences expression of some cell surface proteins, likely as a result of AMPK signaling regulating endocytosis. Integrin and Megalin both contain Dab2 recruiting NPXY motif and may both be regulated through AMPK. I confirmed that AMPK activation increased Dab2 recruitment to clathrin structures at the cell surface but decreased when ARFGAP3 and Arf6 are silenced. Using a transgenic LLC-PK1 cell-line I was able to observe increased levels of miniMegalin on cell surface after AMPK stimulation. In conclusion, this work highlights AMPK regulation of endocytic membrane traffic and that it varies depending on the cell type.</p>

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Section: Kidney Physiologymentioning

confidence: 99%

Regulation of Megalin and Clathrin-Mediated Endocytosis by Amp-Activated Protein Kinase

Leshchyshyn

2024

Preprint

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“…The filtration of blood in the kidneys results in urine production, which functions as storage of waste material from the bloodstream, such as urea and excess of nutrients, including phosphorus (Lawrence et al, 2018). Phosphorus in human urine is mostly in the soluble form (H2PO4 3-/HPO4 3at pH 6 to 7) and it fluctuates between 0.4 and 1 g per litter (0.6 to 1 g person -degradation of soil reduces the capacity for retention of nutrients in intensive agricultural areas, promoting the runoff of phosphorus (Alexander et al, 2015;Schröder et al, 2011;Squire et al, 2015).…”

Section: The Powerful Nutrient Phosphorusmentioning

confidence: 99%

Anaerobic calcium phosphate bio granulation

Cunha¹

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1 day -1 ), depending on dietary habits and where people live (Randall and Naidoo, 2018). Feces are composed of bacterial biomass, undigested food residues, macromolecules (e.g., fibers, proteins, and DNA), and other small molecules (Karu et al., 2018). In feces, phosphorus is mostly in the solid form, representing 5g kg -1 of feces (0.3 to 0.7 g person -1 day -1 ) (Kujawa-Roeleveld and Zeeman, 2006).Although humans excrete on average 95% of the phosphorus consumed, the same does not happen for plants (Wyant et al., 2013). Plants require phosphorus for all the growth and reproductive stages, and phosphorus represents 0.2% of the plant weight (McGrath et al., 2014). Moreover, plants assimilate atmospheric CO2 and sunlight to produce organic carbon and O2. Thus, plants are the primary producers in the food chain and the main source of atmospheric O2, which means that we are dependent on plants for breathing and food production, and in turn, plants are dependent on phosphorus for growth. Besides being an important element in our body, phosphorus also plays a vital role in food production.

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Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells

Qin

Niu

et al. 2020

Acta Pharmaceutica Sinica B

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Function of the nephron and the formation of urine

Cited by 3 publications

References 4 publications

Regulation of Megalin and Clathrin-Mediated Endocytosis by Amp-Activated Protein Kinase

Regulation of Megalin and Clathrin-Mediated Endocytosis by Amp-Activated Protein Kinase

Anaerobic calcium phosphate bio granulation

Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells

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