Function of Mast-Cells

Campani, M

doi:10.1016/s0140-6736(51)92231-3

Cited by 6 publications

(1 citation statement)

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“…Asboe-Hansen (1951 states even more emphatically that the mast cell, under hormonal control, secretes the hyaluronic acid of the ground substance, perhaps by way of a heparin-like precursor. But the facts ( 1 ) that in normal development in the embryo and in chronic inflammation in the adult, the metachromatic ground substance is laid down before the mast cells appear, and (2) that fibroblasts and synovial cells in vitro are capable of forming hyaluronic acid in the medium without the participation of mast cells, both tend to shift the initiation of the production of ground substance to the connective tissue cells themselves (Campani, 1951;Grossfield et al, 1955; Taylor and Saunders, 1956;Castor, 1957). According to Meyer (1950, p. 32): 'fibroblasts secrete large amounts of acid mucopolysaccharides together with a globular native protein, the precollagen.…”

Section: Mast Cells and The Connective Tissuesmentioning

confidence: 99%

The mast cells

Riley¹

1959

252

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'coarse granulocyte' in echinoderms is first recognizable as a connective tissue cell with clear cytoplasm, and thus corresponds to the 'hyaline cell' of Kollmann (1908). Under conditions of good feeding the cell develops bulky refractile spherules which stain with basic dyes. The spherules then progressively become yellow and shrunken; finally often red and acidophilic. Thus the intermediate coarse granulocyte in invertebrates, the cell with colourless, basophilic spherules, bears the most obvious resemblance to the mast cell of higher animals. Kollmann found these cells in the connective tissues of various invertebrate forms which he examined. 'Les cellules spheruleuses. .. restent habituellement cantonnees dans le tissu conjonctif. On peut vraisemblement les comparer aux Mastzellen des Vertebres' (Kollmann, p. 200). Thus it will be observed from the standpoint of comparative morphology that mast cells are regularly demonstrable before the demand for oxygen and nutriment has led to the evolution of a definitive blood-vascular system. Whatever may be the function of the mast cells in these simple organisms it can hardly be concerned with the blood. The common blood cell of many insects appears to be concerned function-* Ehrich's 'Mastzellen' are variously described by later investigators as 'cellules isoplastiques Adrenals, mast cells in, 22 Alimentary tract, lower vertebrates, mast cells in, 9 Amino acids, basic, in mast cell, 125, 126, 162 Amoebocyte with spherules, 6 Amphibia, blood formation in, 7 mast cells in, 7

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Section: Mast Cells and The Connective Tissuesmentioning

confidence: 99%