Sulphur‐35 in connective‐tissue formation

Js, Kennedy

doi:10.1002/path.1700800220

Cited by 12 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fibroblasts actively utilise 35S04 in new connective-tissue formation. This has been demonstrated in a variety of experimental lesions associated with fibrogenesis, such as the repair of wounds (Layton, 1950), experimental silicosis (Curran and Kennedy, 1955) and the carrageenin granuloma (Kennedy, 1960). I n steroid hypertension multiplication of fibroblasts occurs in the media of arteries and arterioles, in the myocardium, and in the interstitial tissue of the kidney.…”

Section: Discussionmentioning

confidence: 95%

Sites of mucopolysaccharide synthesis in the lesions of experimental hypertension in rats

Crane

1962

J. Pathol.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Sites of mucopolysaccharide synthesis in the lesions of experimental hypertension in rats

Crane

1962

J. Pathol.

View full text Add to dashboard Cite

“…It is well established in 36S-sodium sulphate incorporation studies that fibroblasts can synthesize sulphated mucopolysaccharides both in healing wounds and in vitro Kennedy, 1960; Mancini, Vilar, Stein & Fiorini, 1961 ;Glucksmann, 1964). There is no evidence, however, that these substances play an active role in collagen formation.…”

Section: Mucopolysaccharides In Healing Woundsmentioning

confidence: 99%

“…The turnover of both cells and collagen in the intact adult dermis is relatively low (Neuberger & Slack, 1953;Neuberger, 1955; Thompson & Ballou, 1956; Gerber, Gerber & Altman, 1960;Delaunay & Bazin, 1958), whereas the turnover of polysaccharides is quite high (Glucksmann, Howard & Pelc, 1956; Kennedy, 1960; Montagna & Hill, 1957; Glucksmann, 1964). Some adult tissues do display a rapid turnover of collagen.…”

Section: Turnover Of Extracellular Substancesmentioning

confidence: 99%

The Fibroblast and Wound Repair

Ross¹

1968

Biological Reviews

402

128

View full text Add to dashboard Cite

Summary This review of connective tissue repair has attempted to place into historical perspective information obtained by newer approaches. The literature review is incomplete, as it was unfortunately necessary to leave many interesting studies out of the discussion. Emphasis has been placed upon what is known of the inflammatory response, the fine structure of the connective tissue cells in healing wounds and with correlated chemical findings in these tissues. An optimal inflammatory response appears to be an important, rapid, non‐specific stimulus for fibroplasia. It is not clear how inflammation exerts this effect. The inflammatory cells and their enzymes markedly alter the extracellular matrix of injured tissue. The matrix of connective tissue may itself participate in the control of its own synthesis and degradation. It is possible that modification of this environment by injury and/or inflammation with ensuing matrix alteration may provide a stimulus for cell migration and protein synthesis. The converse may also be true, that is, a given level of matrix concentration may have an inhibitory effect upon the connective tissue cells. The inter‐relationships between the connective tissue matrix and the cells, and the possibilities of feedback mechanisms playing a role in maintaining a balance between these two are important areas for future investigation. In this regard, additional questions may be asked concerning the role of the fibroblast in remodelling and degradation of connective tissue. It is not yet clear how important a balance between collagenolytic enzymes and the solubility states, or stability, of collagen are in each connective tissue. It will be interesting to determine which cells make collagenolytic and/or proteolytic enzymes upon appropriate stimulus. It is possible to distinguish between the fibroblast and the monocyte, or potential macrophage with the electron microscope. The rough endoplasmic reticulum with its large numbers of attached ribosomes is extensively developed in the fibroblast in contrast to the monocyte. The endoplasmic reticulum sequesters collagen precursors and other secretory proteins for transport either directly to the extracellular space, as appears to be the case for collagen, or to the Golgi complex as is the case for other exportable proteins. Collagen precursors are secreted into the environment and are not shed from within the cell surface. A number of cytoplasmic alterations have been described for fibroblasts and other cells during various pathological states. The significance of these alterations is not clear. It will be important to distinguish between specific and non‐specific responses to injury, if these alterations are to aid us in understanding the various cellular responses. The source of the fibroblasts in granulation tissue appears to be mesenchymal cells from adjacent tissues rather than blood‐borne precursors. Although contact inhibition can be demonstrated in vitro, it is not clear how important this phenomenon is in vivo, nor are the reasons for the...

show abstract

“…These cells are the sole manufacturers of collagen (1-3), and the synthesizers of essential components of the ground substance such as glycosaminoglycans (3)(4)(5). The rates at which the entrance and multiplication of fibroblasts occur in wounds under normal circumstances are well known.…”

mentioning

confidence: 99%