Fumonisin affects performance and modulates the gene expression of IGF-1 and GHR in Nile tilapia fingerlings and juveniles

Silva, Stefania Caroline Claudino da; Lala, Bruno; Carniatto, Caio Henrique de Oliveira; Schamber, Christiano Rodrigues; Nascimento, Carlos Souza do; Braccini, Graciela Lucca; Porto, Carla; Roldi, Gabriel; Tanamati, Fernanda; Gasparino, Eliane

doi:10.1016/j.aquaculture.2019.04.027

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…When the S6K1 protein is activated in the cell, it phosphorylates several sites, including ribosomal protein S6, to promote the formation of the translation initiation complex ( 49 ). Silva found that IGF-1 is sensitive to changes in nutrients, especially amino acids ( 50 ). The relatively complex interaction between different hormones affects the growth regulation of hormones, among which GH, GHR, and IGF-1 are considered to be the most important growth-regulating genes.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary phenylalanine on growth performance and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) in low fishmeal diets

et al. 2023

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This study aimed to investigate the effects of phenylalanine on the growth, digestive capacity, antioxidant capability, and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) fed a low fish meal diet (15%). Five isonitrogenous and isoenergetic diets with different dietary phenylalanine levels (1.82, 2.03, 2.29, 2.64, and 3.01%) were fed to triplicate groups of 20 fish (initial mean body weight of 36.76 ± 3.13 g). The weight gain rate and specific growth rate were significantly lower (p < 0.05) in the 3.01% group. The trypsin activity in the 2.03% group was significantly higher than that in the control group (p < 0.05). Amylase activity peaked in the 2.64% treatment group. Serum superoxide dismutase, catalase, and lysozyme had the highest values in the 2.03% treatment group. Liver superoxide dismutase and catalase reached their maximum values in the 2.03% treatment group, and lysozyme had the highest value in the 2.29% treatment group. Malondialdehyde levels in both the liver and serum were at their lowest in the 2.29% treatment group. Interleukin factors IL-1β and IL-6 both reached a minimum in the 2.03% group and were significantly lower than in the control group, while IL-10 reached a maximum in the 2.03% group (p < 0.05). The tight junction protein-related genes occludin, claudin-1, and ZO-1 all attained their highest levels in the 2.03% treatment group and were significantly higher compared to the control group (p < 0.05). The intestinal villi length and muscle layer thickness were also improved in the 2.03% group (p < 0.05). In conclusion, dietary phenylalanine effectively improved the growth, digestion, absorption capacity, antioxidant capacity, and intestinal health of O. mykiss. Using a quadratic curve model analysis based on WGR, the dietary phenylalanine requirement of triploid O. mykiss fed a low fish meal diet (15%) was 2.13%.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary phenylalanine on growth performance and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) in low fishmeal diets

et al. 2023

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“…The two genes, GHR and IGF2 , are involved in the growth of fish (Schlueter et al 2007 ; Besseau et al 2013 ; Claudino da Silva et al 2019 ). Investigations of gilthead sea bream ( Sparus aurata ) demonstrated a positive correlation between the expression of GHR and a growth spurt during summer months (Calduch-Giner et al 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro

Schäfer

Kaya

Rebl

et al. 2021

Fish Physiol Biochem

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There are still numerous difficulties in the successful farming of pikeperch in the anthropogenic environment of various aquaculture systems, especially during early developmental steps in the hatchery. To investigate the physiological processes involved on the molecular level, we determined the basal expression patterns of 21 genes involved in stress and immune responses and early ontogenesis of pikeperch between 0 and 175 days post hatch (dph). Their transcription patterns most likely reflect the challenges of growth and feed conversion. The gene coding for apolipoprotein A (APOE) was strongly expressed at 0 dph, indicating its importance for yolk sac utilization. Genes encoding bone morphogenetic proteins 4 and 7 (BMP4, BMP7), creatine kinase M (CKM), and SRY-box transcription factor 9 (SOX9) were highly abundant during the peak phases of morphological changes and acclimatization processes at 4–18 dph. The high expression of genes coding for peroxisome proliferator-activated receptors alpha and delta (PPARA, PPARD) at 121 and 175 dph, respectively, suggests their importance during this strong growth phase of juvenile stages. As an alternative experimental model to replace further in vivo investigations of ontogenetically important processes, we initiated the first approach towards a long-lasting primary cell culture from whole pikeperch embryos. The present study provides a set of possible biomarkers to support the monitoring of pikeperch farming and provides a first basis for the establishment of a suitable cell model of this emerging aquaculture species.

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“…The occurrence of fumonisins have been reported in edible plants like onion, garlic, asparagus, and pea seed [108,109]; in other cereals, mainly in wheat [84,110] as well as in crops like sorghum, beans (white, adzuki, mung), barley, soybean, asparagus spears, and figs [111,112]. Besides this, fumonisins have been found to impact the performance of aquatic animals like the Nile tilapia fingerlings and juveniles [113]. Fumonisins affected the hepatic expression of growth hormone receptor (GHR) and insulin like growth factor 1 (IGF-1) in these species, which is an indication that other aquatic animals and plants could also be affected by fumonisins posing a serious threat to food safety and security.…”

Section: Effects On Agriculture and Foodmentioning

confidence: 99%

Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies

Kamle

Mahato

Devi³

et al. 2019

Toxins

168

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The fumonisins producing fungi, Fusarium spp., are ubiquitous in nature and contaminate several food matrices that pose detrimental health hazards on humans as well as on animals. This has necessitated profound research for the control and management of the toxins to guarantee better health of consumers. This review highlights the chemistry and biosynthesis process of the fumonisins, their occurrence, effect on agriculture and food, along with their associated health issues. In addition, the focus has been put on the detection and management of fumonisins to ensure safe and healthy food. The main focus of the review is to provide insights to the readers regarding their health-associated food consumption and possible outbreaks. Furthermore, the consumers’ knowledge and an attempt will ensure food safety and security and the farmers’ knowledge for healthy agricultural practices, processing, and management, important to reduce the mycotoxin outbreaks due to fumonisins.

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Fumonisin affects performance and modulates the gene expression of IGF-1 and GHR in Nile tilapia fingerlings and juveniles

Cited by 7 publications

References 19 publications

Effect of dietary phenylalanine on growth performance and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) in low fishmeal diets

Effect of dietary phenylalanine on growth performance and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) in low fishmeal diets

Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro

Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies

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