Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns

Abstract

In the biomedical sector the availability of engineered scaffolds and dressings that control and reduce inflammatory states is highly desired, particularly for the management of burn wounds. In this work, we demonstrate for the first time, to the best of our knowledge, that electrospun fibrous dressings of poly(octyl cyanoacrylate) (POCA) combined with polypropylene fumarate (PPF) possess anti-inflammatory activity and promote the fast and effective healing of mild skin burns in an animal model. The fibers produced had an average diameter of (0.8 ± 0.1) µm and they were able to provide a conformal coverage of the injured tissue. The application of the fibrous mats on the burned tissue effectively reduced around 80% of the levels of pro-inflammatory cytokines in the first 48 h in comparison with un-treated animals, and enhanced skin epithelialization. From histological analysis, the skin thickness of the animals treated with POCA : PPF dressings appeared similar to that of one of the naïve animals: (13.7 ± 1.4) µm and (14.3 ± 2.5) µm for naïve and treated animals, respectively. The density of dermal cells was comparable as well: (1100 ± 112) cells mm−2 and (1358 ± 255) cells mm−2 for naïve and treated mice, respectively. The results demonstrate the suitability of the electrospun dressings in accelerating and effectively promoting the burn healing process.

Anomaly Detection in Nanofibrous Materials by CNN-Based Self-Similarity

“…[ 19 , 20 ]), synthetic polymers, both organic and inorganic (such as polystyrene, polyamidimide, polyacrylonitrile, polysiloxanes, etc.) [ 21 , 22 ], and metallic polymers such as silver, gold, manganese, etc. [ 23 ].…”

Recent Advances in Experimental Burn Models

“…Anti-inflammatory strategies Silibinin-loaded pomegranate oil + nanocapsules [17] Topical Fumarate + poly nanofibers [18] Topical Bromelain + chitosan nanofibers [9] Topical IgM-N2 peptide [40] Intravenous infusion…”

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

“…The mice dorsal skin was shaved with an electric clipper, and the burn wounds were induced as previously reported. 45 Briefly, mice were covered and orientated in order to have only the desired portion of skin (approximately 1.5 cm 2 ) exposed to a narrow band UVB light source (TL01 fluorescent tubes, Philips, UK, l max = 312 nm), able to produce an even field of irradiation (maximal dose of 500 mJ cm À2 ). Following the burn induction, the exposed area was immediately treated by placing KC0 and KC10 fibers and protected with Tegardermt to avoid the removal of the matrices.…”