Fulminant neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccination: A need for reconsideration?

Motahharynia, Ali; Naghavi, Saba; Shaygannejad, Vahid; Adibi, Iman

doi:10.1016/j.msard.2022.104035

Cited by 9 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, it was necessary to consider whether the COVID-19 vaccination would lead to a relapse of NMOSD (31,32). On the other hand, some patients would have new-onset NMOSD after the COVID-19 vaccination (33)(34)(35)(36). This is why COVID-19 became a hot topic in NMOSD research.…”

Section: Discussionmentioning

confidence: 99%

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Ruan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a demyelinating syndrome of the central nervous system. A tremendous amount of literature on NMOSD has been published. This study aimed to perform a bibliometric analysis of the publications on NMOSD and show its hotspots and development trends.MethodsWe used the Web of Science Core Collection as a database and searched the literature published between 2002 and 2022. CiteSpace, VOSviewer, online bibliometric platform, and R-bibliometrix were used to conduct bibliometric analysis and network visualization, including the number of publications, citations, countries/regions, institutions, journals, authors, references, and keywords.ResultsA total of 3,057 publications on NMOSD were published in 198 journals by 200 authors at 200 institutions from 93 countries/regions. The United States published the most literature and made great contributions to this field. The Mayo Clinic was the institution with the largest number of publications. The journal with the most publications was Multiple Sclerosis and Related Disorders, and the most co-cited journal was Neurology. The author with the most publications was Fujihara, K., while the most frequently co-cited author was Wingerchuk, DM. The current research hotspots may be focused on “efficacy,” “multicenter,” “interleukin-6 receptor blockade,” “safety,” “azathioprine,” “tolerance,” and “adult”.ConclusionThis study was the first bibliometric analysis of publications on the NMOSD field, visualizing its bibliometric characteristics and gaining insight into the direction, hotspots, and development of global NMOSD research, which may provide helpful information for researchers. Future research hotspots might be conducting randomized controlled trials on targeted immunotherapy in the NMOSD field.

show abstract

Section: Discussionmentioning

confidence: 99%

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Ruan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Molecular mimicry of SARS-CoV2 antigens and neurological self-antigens is another potential mechanism. It was reported that both natural SARS-CoV-2 infection and SARS-CoV-2 vaccination can induce the formation of AQP-4 Ab and lead to newly diagnosed NMOSD, or it can also trigger a relapse in patients who already had an established diagnosis [5,[10][11][12][13]. Of note, the postimmunization NMOSD cases are not limited to a certain type or certain company-made vaccine [10].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Karaca¹

2022

J Neurol Psychol

View full text Add to dashboard Cite

Background: Development of autoimmune neurological disorders after Coronavirus Disease 2019 (COVID-19) has been reported. Though many cases of multiple sclerosis developing after COVID-19 are present in current literature, Neuromyelitis Optica Spectrum Disorder (NMOSD) is much rarer sequela of the disease.Methods: Two cases that meet the international consensus diagnostic criteria for NMOSD were encountered at a regional hospital in West Texas in the same month. Both were preceded by acute SARS-CoV-2 infection and developed newly diagnosed NMOSD with Aquaporin-4 Protein Antibody seropositivity.Results: Case 1 was a 28-year-old Hispanic female who presented with opsoclonus and ophthalmoplegia; Case 2 was a 20-year-old African American female who presented with transverse myelitis. Both patients had no neurological co morbidities or symptoms prior to SARS-CoV-2 infection. Neither of them was vaccinated for COVID-19, and both were of non-Caucasian ethnicity. They presented with a typical features including younger onset, ocular presentation of opsoclonus, negative neuroimaging, no response to steroids, and relapse after a short interval. Conclusion: New developments of NMOSD in previously healthy individuals can be a neurological sequela of COVID-19, especially among unvaccinated individuals. The correlation and pathophysiology of NMOSD after COVID-19 are not fully understood, but molecular mimicry of the virus and cytokine storm are postulated mechanisms. Additional observational studies are needed to further explore the correlation between acute COVID-19 infection and NMOSD.

show abstract

“…Moreover, the symptoms of MOGAD appeared after a mean ± SD of 16.6 ± 14.9 days after the onset of COVID-19, while in other demyelinating diseases, onset symptoms occurred following about 10 days. [80][81][82][83][84] According to a systematic review of CNS demyelination published by Ismail et al in 2021, 54 3 cases of MOGAD have been reported. Although our research supports the findings of the previous systematic review, we report more cases than the previous studies.…”

Section: Mogad Diagnosis Following Covid-19 Infectionmentioning

confidence: 99%

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and COVID-19: A Systematic Review

Mirmosayyeb

Ghaffary

Dehghan

et al. 2023

J Cent Nerv Syst Dis

Self Cite

View full text Add to dashboard Cite

Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an uncommon neurological disease affecting the central nervous system (CNS). Numerous neurological disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), acute transverse myelitis (ATM), and MOGAD, have been reported following the COVID-19 infection during the current COVID-19 pandemic. On the other hand, it has been suggested that patients with MOGAD may be at greater risk for infection (particularly in the current pandemic). Objective In this systematic review, we gathered separately 1) MOGAD cases following COVID-19 infection as well as 2) clinical course of patients with MOGAD infected with COVID-19 based on case reports/series. Methods 329 articles were collected from 4 databases. These articles were conducted from inception to March 1st, 2022. Results Following the screening, exclusion criteria were followed and eventually, 22 studies were included. In 18 studies, a mean ± SD time interval of 18.6 ± 14.9 days was observed between infection with COVID-19 and the onset of MOGAD symptoms. Symptoms were partially or completely recovered in a mean of 67 days of follow-up. Among 4 studies on MOGAD patients, the hospitalization rate was 25%, and 15% of patients were hospitalized in the intensive care unit (ICU). Conclusion Our systematic review demonstrated that following COVID-19 infection, there is a rare possibility of contracting MOGAD. Moreover, there is no clear consensus on the susceptibility of MOGAD patients to severe COVID-19. However, obtaining deterministic results requires studies with a larger sample size.

show abstract

Fulminant neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccination: A need for reconsideration?

Cited by 9 publications

References 5 publications

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Emerging trends and research foci of neuromyelitis optica spectrum disorder: a 20-year bibliometric analysis

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and COVID-19: A Systematic Review

Contact Info

Product

Resources

About