Fulminant Deletion of Myoglobin From Myocardial Fibres in State of Acute Cardiac Failure Inducing Sudden Cardiac Arrest

Ishiyama, Ikuo; Kamiya, M.; Rose, Michael; Komuro, E.; Takatsu, Akihiro

doi:10.1016/s0140-6736(82)91376-9

Cited by 18 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Myoglobin is the oxygen carrier protein in cardiac and skeletal muscles and the release of myoglobin from heart muscle is one of the earliest signs of ischaemic injury [5,9,10]. The release of myoglobin from skeletal muscles has been found to be associated with a variety of types of rhabdomyolysis [16] and also with electrical injury [8].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigations to demonstrate vital direct traumatic damage of skeletal muscle

et al. 1991

View full text Add to dashboard Cite

The muscle proteins actin, myosin, desmin and myoglobin were investigated in traumatically damaged human and animal skeletal muscle using an immunohistochemical PAP-method. A depletion of all the proteins investigated was observed in muscle fibres damaged in the antemortem period. The antigens could however also be demonstrated in the otherwise empty sarcolemma, the discoid disintegration zones of the fibres and between the fibres. The depletion begins immediately after the trauma and myoglobin is the first to be affected. No such changes could be observed after post mortem muscle damage. The antigens could be demonstrated until 72 hours post mortem. The demonstration of protein depletion is an important addition to the light microscopical findings in vital muscle alterations.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigations to demonstrate vital direct traumatic damage of skeletal muscle

et al. 1991

View full text Add to dashboard Cite

show abstract

“…They proposed the hypothesis that elevated plasma remnant lipoprotein levels might impair endothelium‐dependent vasorelaxation in narrowed coronary arteries as an early event, and activated LOX‐1 receptor and Rho‐kinase pathway in smooth muscle cells then cause coronary artery vasospasm and cardiac arrest. Coronary artery vasospasm could result in multiple necroses of cardiomyocytes, with potassium released from necrotic sites causing VA …”

Section: Pathogenetic Hypotheses About Sundsmentioning

confidence: 99%

“…2 They proposed the hypothesis that elevated plasma remnant lipoprotein levels might impair endotheliumdependent vasorelaxation in narrowed coronary arteries as an early event, and activated LOX-1 receptor and Rho-kinase pathway in smooth muscle cells then cause coronary artery vasospasm and cardiac arrest. Coronary artery vasospasm could result in multiple necroses of cardiomyocytes, with potassium released from necrotic sites causing VA. 42 Others risk factors, such as excessive vanadium intake, inhibition of Na, K-ATPase and H, K-ATPase activity, 43 rapid eye movement bursts, 14,44 plasma testosterone, 45 epilepsy, 46,47 diabetes mellitus, 48 melioidosis bacteria, 49 toxic shock, 50 etc, may also be involved in the pathogenesis of SUNDS. In general, SUNDS specifically happens during nocturnal sleep, suggesting that the unique Hmong sleep disorder profile of a high prevalence of sleep apnea, sleep paralysis, nightmares, and other rapid eye movement-related sleep abnormalities 41 plays an important role in SUNDS attacks.…”

Section: Remnant Lipoproteins and Coronary Artery Vasospasmmentioning

confidence: 99%

Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma

Zheng

et al. 2018

JAHA

View full text Add to dashboard Cite

“…edema, wavy fibres and contraction bands, even when due to coronary artery disease (CAD), are often sparsely detected with the common staining methods such as hematoxylin-eosin. With other methods, especially the immunohistochemical ones, early ischaemic lesions and acute myocardial infarctions (AMI) can sometimes be diagnosed [5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

TUNEL: a useful screening method in sudden cardiac death

Edston

Gröntoft

Johnsson

2002

International Journal of Legal Medicine

View full text Add to dashboard Cite

The primary objective of this study was to investigate if detection of apoptosis in the heart can be used to diagnose early myocardial ischaemia. The material consisted of myocardial tissue from autopsy cases: 10 cases with occlusive, thrombotic coronary artery disease and acute myocardial infarction, 10 cases of sudden cardiac death without coronary artery disease (CAD) and 8 controls without cardiovascular disease and with known causes of death. Necrotic changes in the myocardium were detected with hematoxylin-erythrosin-saffron, Mallory's PTAH stain and with antibodies against complement 9. Apoptotic nuclei were visualised with two different kits using the terminal deoxynucleotidyl transferase-mediated desoxyuridinetriphosphate nick end-labeling (TUNEL) method on histological sections. In the patients with CAD, early myocardial infarction was found in one defined area of the ventricular wall; apoptotic myocyte nuclei were observed not in the necrotic lesions, but evenly spread usually without a gradient, all over the myocardium with a mean number per high power field of 29% (range 3-56%) of the total number of myocyte nuclei. In the sudden cardiac deaths without CAD, necrosis was scarce and distributed both focally and irregularly in both the left and right ventricular walls. With few exceptions, the percentage of apoptotic myocyte nuclei exceeded 20% in all sections (mean 24%, range 0-68%). No difference was seen between patients with CAD and those without CAD (p > 0.05). With the TUNEL method, positively stained nuclei were seen very early and extensively all over the myocardium. It is not certain that they represent true apoptosis induced by ischemia, but TUNEL appears to be a useful screening method in cases where sudden cardiac death is suspected.

show abstract

Fulminant Deletion of Myoglobin From Myocardial Fibres in State of Acute Cardiac Failure Inducing Sudden Cardiac Arrest

Cited by 18 publications

References 7 publications

Immunohistochemical investigations to demonstrate vital direct traumatic damage of skeletal muscle

Immunohistochemical investigations to demonstrate vital direct traumatic damage of skeletal muscle

Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma

TUNEL: a useful screening method in sudden cardiac death

Contact Info

Product

Resources

About