Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure

Huo, Shuaidong; Jiang, Ying; Gupta, Akash; Jiang, Ziwen; Landis, Ryan F.; Hou, Singyuk; Liang, Xing‐Jie; Rotello, Vincent M.

doi:10.1021/acsnano.6b04207

Cited by 118 publications

(114 citation statements)

References 40 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Developments in nanotechnology have revealed metal nanoparticles as promising new generation antibacterial agents 7–9 . However, the mechanism of action of nanoparticles remains enigmatic.…”

Section: Introductionmentioning

confidence: 99%

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Ahmed

Raman

Veerappan

2018

Sci Rep

View full text Add to dashboard Cite

Bacterial resistance is a major clinical problem, which is compounded by both a lack of new antibiotics and emergence of multi- and extremely-drug resistant microbes. In this context, non-toxic nanoparticles could play an important role in conferring protection against bacterial infections and in this study we have made an attempt to show the usefulness of jacalin capped platinum nanoparticles in protecting zebrafish against multiple infections with Aeromonas hydrophila. Our results also indicate that use of nanoparticles promotes adaptive immune response against the pathogen, so much so that zebrafish is able to survive repetitive infection even after twenty one days of being treated with jacalin-capped platinum nanoparticles. This is significant given that platinum salt is not antibacterial and jacalin is non-immunogenic. Our study for the first time reveals a novel mechanism of action of nanoparticles, which could form an alternate antibacterial strategy with minimal bacterial resistance.

show abstract

Section: Introductionmentioning

confidence: 99%

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Ahmed

Raman

Veerappan

2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Loss of membrane potential and disruption of respiratory chain has also been observed with Au, 43 Cu 37 and NiO NPs. 44 …”

Section: Agmentioning

confidence: 95%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

397

233

View full text Add to dashboard Cite

Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

show abstract

“…Cationic NPs act as self‐therapeutic, anti‐microbial systems, penetrating bacterial membranes and causing membrane disruption. They are also substantially toxic to mammalian cells, being able to induce homolysis …”

Section: Selection Of Nanoparticle Typementioning

confidence: 99%

“…Rotello et al. suggest Zwitterionic ligand‐capped AuNPs as an ideal option to increase circulation time, as zwitterionic surfaces inhibit bacterial adhesion, prevent biofilm formation and allow for a correct orientation, due to their charge . In a study employing polymeric NPs loaded with Camptothecin (CPT; (S)‐(+)‐4‐ethyl‐4‐hydroxy‐1H‐pyrano [3′, 4′ : 6,7] indolizino [1, 2‐b] quinoline‐3,14‐(4H,12H)‐dione) (Figure ), it was specified that a zeta potential under 15 mV and a particle size of 150 nm favors NP accumulation in tumors in a more efficient way than elevated surface charges and large peptide sizes, which are phagocyted more efficiently .…”

Section: Selection Of Nanoparticle Typementioning

confidence: 99%

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

et al. 2018

View full text Add to dashboard Cite

To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological systems and liberation mechanisms into the target cells, also need to be taken into account. Multiple advantages arise from the use of nanoparticles, such as the capability to solubilize hydrophobic compounds and an increased bioavailability. Those advantages justify the extensive and delicate study that should be undertaken in order to use them as drug delivery agents. One of the most important factors for the design of a drug delivery system with nanoparticles is achieving a high drug-to-nanoparticle ratio. In this Minireview, all of these key factors, both physicochemical and biological, are described, and special emphasis is placed on loading methods employed to introduce drugs into nanoparticles.

show abstract

Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure

Cited by 118 publications

References 40 publications

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Nanomaterials for alternative antibacterial therapy

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

Contact Info

Product

Resources

About