With the rapid advancement in artificial intelligence, wearable electronic skins have attracted substantial attention. However, the fabrication of such devices with high elasticity and breathability is still a challenge and highly desired. Here, a route to develop an all-fiber structured electronic skin with a scalable electrospinning fabrication technique is reported. The fabricated electronic skin is demonstrated to exhibit high pressure sensing with a sensitivity of 0.18 V kPa −1 in the detection range of 0-175 kPa. This wearable device could maintain prominent sensing performance and mechanical stability in the presence of large deformation, even when the elastic deformation is up to 50%. The electronic skin is easily conformable on different desired objects for real-time spatial mapping and long-term tactile sensing. Besides, it possesses high gas permeability with a water vapor transmittance rate of 10.26 kg m −2 d −1 . More importantly, the electronic skin is capable of working in a self-powered manner and even serves as a reliable power source to effectively drive small electronics. Possessing several compelling features, such as high sensitivity, high elasticity, high breathability as well as being self-powered and scalable in fabrication, the presented device paves a pathway for smart electronic skins.