Fully Electrical Microarrays

Hintsche, R.; Elsholz, Bruno; Piechotta, G.; Woerl, R.; Schabmueller, C G J; Albers, Jörg; Dharuman, Venkataraman; Nebling, Eric; Hanisch, Anke; Blohm, Lars; Hofmann, Franz; Holzapfl, B.; Frey, Alexander; Paulus, Christian; Schienle, M.; Thewes, R.

doi:10.1016/s1871-0069(05)01006-2

Cited by 3 publications

(2 citation statements)

References 97 publications

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“…In collaboration with Siemens AG (Erlangen, Germany) and Infineon Technologies AG (Munich, Germany), a 128 position sensor array chip [ 139 ] and a 16 position chip were developed [ 140 , 141 ] carrying interdigitated microelectrodes ( Figure 6 B). Quite early during development, the first applications based on this electrochemical biochip technology focused on multiplex detection of security sensitive toxins were developed using a prototype reader platform (ePaTox system) [ 142 , 143 ]. Based on these promising results, Bruker developed a portable and ruggedized platform for on-site usage called pBDi as well as several commercially available detection kits for the detection of security sensitive proteotoxins, bacteria and orthopox viruses [ 92 , 93 ].…”

Section: Portable Immunoassay Techniques With Multiplexing Capabilmentioning

confidence: 99%

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Pöhlmann

Elßner

2020

Toxins

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Biological toxins are a heterogeneous group of high molecular as well as low molecular weight toxins produced by living organisms. Due to their physical and logistical properties, biological toxins are very attractive to terrorists for use in acts of bioterrorism. Therefore, among the group of biological toxins, several are categorized as security relevant, e.g., botulinum neurotoxins, staphylococcal enterotoxins, abrin, ricin or saxitoxin. Additionally, several security sensitive toxins also play a major role in natural food poisoning outbreaks. For a prompt response to a potential bioterrorist attack using biological toxins, first responders need reliable, easy-to-use and highly sensitive methodologies for on-site detection of the causative agent. Therefore, the aim of this review is to present on-site immunoassay platforms for multiplex detection of biological toxins. Furthermore, we introduce several commercially available detection technologies specialized for mobile or on-site identification of security sensitive toxins.

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Section: Portable Immunoassay Techniques With Multiplexing Capabilmentioning

confidence: 99%

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Pöhlmann

Elßner

2020

Toxins

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“…At a low-density chip, the transducer is realized in several array positions (e.g., of 0.5-mm diameter) with inter-digitated electrode (e.g., of 800-nm width separated by 400-nm-wide gaps) [41]. Such microarrays can be freely designed for the particular use.…”

Section: Commentmentioning

confidence: 99%

Electrochemical nucleic acid-based biosensors: Concepts, terms, and methodology (IUPAC Technical Report)

Labuda

Oliveira-Brett

Evtugyn

et al. 2010

Pure and Applied Chemistry

213

113

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An electrochemical nucleic acid (NA)-based biosensor is a biosensor that integrates a nucleic acid as the biological recognition element and an electrode as the electrochemical signal transducer. The present report provides concepts, terms, and methodology related to biorecognition elements, detection principles, type of interactions to be addressed, and construction and performance of electrochemical NA biosensors, including their critical evaluation, which should be valuable for a wide audience, from academic, biomedical, environmental, and food-testing, drug-developing, etc. laboratories to sensor producers.

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Multiplex Detection of Biothreat Agents Using an Automated Electrochemical ELISA Platform

Pöhlmann

Bellanger

Drevinek

et al. 2017

Procedia Technology

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Fully Electrical Microarrays

Cited by 3 publications

References 97 publications

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Electrochemical nucleic acid-based biosensors: Concepts, terms, and methodology (IUPAC Technical Report)

Multiplex Detection of Biothreat Agents Using an Automated Electrochemical ELISA Platform

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