Fully automated magnetically controlled capsule endoscopy for examination of the stomach and small bowel: a prospective, feasibility, two-centre study

Xiao, Yufeng; Wu, Zhiguang; He, Song; Zhou, Yuanyuan; Zhao, Yue; He, Jialin; Xue, Peng; Yang, Zhaoxia; Lv, Qing-Jian; Yang, Huan; Bai, Jianying; Fan, Chaoqiang; Tang, Bo; Hu, C.; Jie, Meng-Meng; Liu, En; Lin, Hui; Koulaouzidis, Anastasios; Zhao, Xiao‐Fan; Yang, Shi‐Ming; Xie, Xia

doi:10.1016/s2468-1253(21)00274-0

Cited by 29 publications

(21 citation statements)

References 29 publications

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“…Consequently, it is expected that a genuinely “panenteric” (mouth-to-anus) capsule endoscope will be available in the near future 298 . In addition, magnetically guided capsule endoscopy has been developed and clinically assessed for examination of the stomach or combined stomach and small bowel 299 300 . However, active capsules with embedded AI, microbiota or tissue sampling, or therapeutic options, are still in the early stages of development 300 .…”

Section: Innovationsmentioning

confidence: 99%

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022

et al. 2022

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Main Recommendations MR1 ESGE recommends small-bowel capsule endoscopy as the first-line examination, before consideration of other endoscopic and radiological diagnostic tests for suspected small-bowel bleeding, given the excellent safety profile of capsule endoscopy, its patient tolerability, and its potential to visualize the entire small-bowel mucosa.Strong recommendation, moderate quality evidence. MR2 ESGE recommends small-bowel capsule endoscopy in patients with overt suspected small-bowel bleeding as soon as possible after the bleeding episode, ideally within 48 hours, to maximize the diagnostic and subsequent therapeutic yield.Strong recommendation, high quality evidence. MR3 ESGE does not recommend routine second-look endoscopy prior to small-bowel capsule endoscopy in patients with suspected small-bowel bleeding or iron-deficiency anemia.Strong recommendation, low quality evidence. MR4 ESGE recommends conservative management in those patients with suspected small-bowel bleeding and high quality negative small-bowel capsule endoscopy.Strong recommendation, moderate quality evidence. MR5 ESGE recommends device-assisted enteroscopy to confirm and possibly treat lesions identified by small-bowel capsule endoscopy.Strong recommendation, high quality evidence. MR6 ESGE recommends the performance of small-bowel capsule endoscopy as a first-line examination in patients with iron-deficiency anemia when small bowel evaluation is indicated.Strong recommendation, high quality evidence. MR7 ESGE recommends small-bowel capsule endoscopy in patients with suspected Crohn’s disease and negative ileocolonoscopy findings as the initial diagnostic modality for investigating the small bowel, in the absence of obstructive symptoms or known bowel stenosis.Strong recommendation, high quality evidence. MR8 ESGE recommends, in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging, small-bowel capsule endoscopy as a subsequent investigation if deemed likely to influence patient management.Strong recommendation, low quality evidence. MR9 ESGE recommends, in patients with established Crohn’s disease, the use of a patency capsule before small-bowel capsule endoscopy to decrease the capsule retention rate.Strong recommendation, moderate quality evidence. MR10 ESGE recommends device-assisted enteroscopy (DAE) as an alternative to surgery for foreign bodies retained in the small bowel requiring retrieval in patients without acute intestinal obstruction.Strong recommendation, moderate quality evidence. MR11 ESGE recommends DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy (except for Billroth II patients).Strong recommendation, moderate quality evidence.

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Section: Innovationsmentioning

confidence: 99%

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022

et al. 2022

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“…There will likely be differences between learning curves, and therefore, the cost of training endoscopist in MACE may be cheaper than conventional endoscopy. A fully automated MACE procedure was recently described and may further reduce the cost of MACE by leveraging artificial intelligence 25. Regardless, the cost of capsule endoscopes will need to be reduced significantly before MACE can be adopted in routine practice.…”

Section: Discussionmentioning

confidence: 99%

Cost comparison of oral, transnasal and magnet assisted capsule endoscopy in the examination of the upper gastrointestinal tract in patients with dyspepsia

Tai

Healy

Thokala

et al. 2022

Frontline Gastroenterol

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IntroductionConventional oral upper gastrointestinal (GI) endoscopy can obe uncomfortable. By comparison, transnasal endoscopy (TNE) and magnet assisted capsule endoscopy (MACE) have superior tolerability. A cost comparison of competing upper GI endoscopic modalities have yet to be performed.MethodsWe performed a cost comparison study of oral, TNE and MACE by a combination of activity-based costing and averaging of fixed costs over 24 481 upper GI endoscopies performed for dyspepsia over a 10-year period.ResultsOn average, 9.4 procedures were performed daily. TNE was cheapest at €125.90 per procedure, costing 30% less than oral endoscopy at €184.10 and threefold cheaper than MACE at €407.10. Flexible endoscope reprocessing cost €53.80. TNE was cheaper than oral endoscopy as sedation was not required. Oral endoscopies have a further rate of infectious complications, estimated to cost €16.20 per oral procedure in inpatient admissions. Oral and TNE equipment are more expensive to purchase and maintain than MACE costing €79 330 and €81 819, respectively compared with MACE at €15 420 per annum. However, capsule endoscopes cost significantly more per procedure at €369.00 than the consumables for flexible endoscopy (per oral €12.30, TNE €5.30).ConclusionsTNE cost less to perform than conventional per oral endoscopy. The cost of capsule endoscopes will need to be reduced significantly if routine use is to be expected.

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“…The stomach has a certain storage capacity, which creates suitable conditions for the retention of sensor materials. At present, capsule endoscopy can remain in the stomach after oral administration to image the cancer, ulcers and bleeding in the stomach [46,47]. Further laboratory research can even detect physicochemical changes in gastric temperature, gas components, etc, which could be used to monitor the living habits and health of the patient [48,49].…”

Section: Construction Of the Digestive Tractmentioning

confidence: 99%

Developing sensor materials for screening intestinal diseases

Zhao¹,

Zhang²,

Chen³

et al. 2022

Mater. Futures

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Intestinal diseases have always been the focus of clinicians and scientific researchers, which have high mortality and morbidity rates, and bring huge encumbrance on the public medical system and economy worldwide. In the progression of many intestinal diseases, early diagnosis and intervention are valuable. Fortunately, the emergence of sensor materials can effectively assist clinical early diagnosis and health monitoring. By accurately locating the lesion and sensitively analyzing the level of disease markers, these sensor materials can help to precisely diagnose the stage and state of lesions, thereby avoiding delaying the treatment. In this review, we provide a comprehensive and in-depth knowledge into diagnosing and monitoring intestinal diseases with the assistance of sensor materials, particularly emphasizing the design and application of them in bioimaging and biodetection. This review is dedicated to conveying the practical applications of sensor materials in the intestine, a critical analysis of their mechanisms and applications, and discussion of their future roles in medicine. We believe that this review would promote the multidisciplinary communication between material science, medicine, and the relevant engineering fields, thus improving the clinical translation of sensor materials

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Fully automated magnetically controlled capsule endoscopy for examination of the stomach and small bowel: a prospective, feasibility, two-centre study

Cited by 29 publications

References 29 publications

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022

Cost comparison of oral, transnasal and magnet assisted capsule endoscopy in the examination of the upper gastrointestinal tract in patients with dyspepsia

Developing sensor materials for screening intestinal diseases

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