Fullerene C60 nanomaterial induced oxidative imbalance in gonads of the freshwater fish, Anabas testudineus (Bloch, 1792)

Sumi, N.; Chitra, K. C.

doi:10.1016/j.aquatox.2019.03.003

Cited by 27 publications

(7 citation statements)

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“…[31][32][33] In other cases, the fullerenes are used as potential radical scavengers to reduce the concentration of reactive oxygen species (ROS). [34][35][36] Nevertheless, there are still few studies on investigation of quantitative structure-activity relationship for fullerene derivatives. The current study examined the relationship between the antitumor effect and the chemical nature of functional groups incorporated in the structures of water-soluble fullerenes using the approach of molecular simulations.…”

Section: Discussionmentioning

confidence: 99%

<p>Fullerene Derivatives as Lung Cancer Cell Inhibitors: Investigation of Potential Descriptors Using QSAR Approaches</p>

Huang¹,

Kraevaya²,

Voronov³

et al. 2020

IJN

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Background: Nanotechnology-based strategies in the treatment of cancer have potential advantages because of the favorable delivery of nanoparticles into tumors through porous vasculature. Materials and Methods: In the current study, we synthesized a series of water-soluble fullerene derivatives and observed their anti-tumor effects on human lung carcinoma A549 cell lines. The quantitative structure-activity relationship (QSAR) modeling was employed to investigate the relationship between anticancer effects and descriptors relevant to peculiarities of molecular structures of fullerene derivatives. Results: In the QSAR regression model, the evaluation results revealed that the determination coefficient r 2 and leave-one-out cross-validation q 2 for the recommended QSAR model were 0.9966 and 0.9246, respectively, indicating the reliability of the results. The molecular modeling showed that the lack of chlorine atom and a lower number of aliphatic single bonds in saturated hydrocarbon chains may be positively correlated with the lung cancer cytotoxicity of fullerene derivatives. Synthesized water-soluble fullerene derivatives have potential functional groups to inhibit the proliferation of lung cancer cells. Conclusion: The guidelines obtained from the QSAR model might strongly facilitate the rational design of potential fullerene-based drug candidates for lung cancer therapy in the future.

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Section: Discussionmentioning

confidence: 99%

<p>Fullerene Derivatives as Lung Cancer Cell Inhibitors: Investigation of Potential Descriptors Using QSAR Approaches</p>

Huang¹,

Kraevaya²,

Voronov³

et al. 2020

IJN

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“…For example Takahashi et al, reported that the toxicity of oral administration of fullerene C60 is relatively low and no marked changes was detected or observed in the different tissues after long-term administration of fullerene C60 in rats (18). However, Sumi et al, demonstrated that using sublethal concentrations of fullerene C60 nanoparticle in freshwater fish noticeably decreased the antioxidant enzymes activities, and increased h ydrogen peroxide production as well as lipid peroxidation in the gonads (35). Although in the current study we determined the fullerene C60 effect on the antioxidant parameters in the testes of diabetic rats, the hormonal changes, trophic factors, inflammatory and apoptotic signals as well as other parameters related to the reproductive and testicular dysfunction in diabetic condition were not determined.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Effects of Fullerene C60 on Markers of Oxidative Stress in the Testes of Streptozotocin-Induced Diabetic Rats

Ranjbar

Shahyad

Namdar

et al. 2021

J Adv Med Biomed Res

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“…Weight, overall length and body length are important index of clownfish growth state. Previous studies investigated that different concentrations fullerene nanomaterials can induce reproductive toxicity in freshwater fish [15], nanoparticles can enter cells to produce cytotoxicity [16][17][18], and hydroxylated fullerenes in rat liver lead to cell death and decreased ATP levels [19]. However, there is a close relationship between pollutant exposure concentration and health.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Characterizations of Fullerene Nanomaterials Potentiate Muscle of Clownfish (Amphiprion Ocellaris)

Huang¹,

Zhao²,

Lin³

et al. 2021

Preprint

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Fullerene nanomaterials exposure often causes a variety of diseases. Many studies have pointed out that fullerene nanomaterials can be studied in fish. However, there are few studies on health risk assessment of clownfish with lower doses of fullerene nanoparticles or different exposure durations. In this study, we set 1.5% and 3.0% for low- and high-dose fullerene nanomaterials exposure concentrations, respectively. Meanwhile, we performed a time-series analysis to investigate that the activation of lipid and amino acids metabolism after fullerene nanomaterials exposure in clownfish. 1368 metabolites were detected from clownfish by using liquid chromatography-mass spectrometry (LC-MS) analyses. Our results suggest that exposure to lower fullerenes nanoparticles may have a certain promoting effect on clownfish overall length, body length and weight. At the same time, the activation of potential metabolic pathways enriched by different metabolites in KEGG pathway may also indicate the positive promoting effect of fullerene nanoparticles after exposure. The present work indicates that it is particularly important to find the concentration window for fullerene nanomaterials to improve government safety guidelines, especially when these are applied to assess the health risk of human.

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Fullerene C60 nanomaterial induced oxidative imbalance in gonads of the freshwater fish, Anabas testudineus (Bloch, 1792)

Cited by 27 publications

References 50 publications

<p>Fullerene Derivatives as Lung Cancer Cell Inhibitors: Investigation of Potential Descriptors Using QSAR Approaches</p>

<p>Fullerene Derivatives as Lung Cancer Cell Inhibitors: Investigation of Potential Descriptors Using QSAR Approaches</p>

Assessing the Effects of Fullerene C60 on Markers of Oxidative Stress in the Testes of Streptozotocin-Induced Diabetic Rats

Metabolomic Characterizations of Fullerene Nanomaterials Potentiate Muscle of Clownfish (Amphiprion Ocellaris)

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