Full thickness macular hole following intravitreal ranibizumab injection for diabetic macular edema; a rare complication or coincidence?

Arifoğlu, Hasan Basri; Haşhaş, Arzu Seyhan Karatepe; Erşekerci, Tülay Karacan; Ataş, Mustafa

doi:10.4103/0301-4738.158109

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…6 There have also been occasional reports of macular hole development following anti-vascular endothelial growth factor injections for diabetic macular edema. 9,10 In summary, we present two patients who developed full-thickness macular holes 6 months after PRP. The relationship between hole formation and previous PRP in these two cases is unclear and possibly coincidental.…”

Section: Discussionmentioning

confidence: 96%

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Full-Thickness Macular Hole Formation Following Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Alsberge¹,

McDonald

2023

RETINAL Cases &Amp; Brief Reports

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Purpose: To report two patients who developed full-thickness macular holes following panretinal photocoagulation for proliferative diabetic retinopathy.Methods: Case series.Results: Case 1 was a 58-year-old woman with Type 1 diabetes mellitus and proliferative diabetic retinopathy and Case 2, a 72-year-old man with Type 2 diabetes mellitus and proliferative diabetic retinopathy. Before panretinal photocoagulation, each patient had an epiretinal membrane and an irregular foveal contour noted on optical coherence tomography. At 2 months follow-up, each patient showed foveal floor thinning and Case 2 also had a lamellar macular hole. At 6 months follow-up, each patient had a fullthickness macular hole. Each were successfully repaired with vitrectomy, membrane peeling, and gas tamponade. Conclusion:The relationship between hole formation and previous panretinal photocoagulation in the patients reported here is unclear and possibly coincidental.

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Section: Discussionmentioning

confidence: 96%

“…6 There have also been occasional reports of macular hole development following anti–vascular endothelial growth factor injections for diabetic macular edema. 9,10…”

Section: Discussionmentioning

confidence: 99%

Full-Thickness Macular Hole Formation Following Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Alsberge¹,

McDonald

2023

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

show abstract

Ranibizumab

2017

Reactions Weekly

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Two cases of diabetic macular edema complicated by an atypical macular hole

et al. 2020

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Background: Here we report two patients who developed an atypical macular hole (MH) during the treatment course for diabetic macular edema (DME). Case presentations: Patient 1 was a 73-year-old male. Optical coherence tomography (OCT) revealed perifoveal retinoschisis (RS) in addition to cystoid macular edema and serous retinal detachment (SRD) in his left eye, and that an MH had developed during the clinical course. A convex surface was formed at the MH margin toward the vitreous cavity, and granular shadows were observed in the fluid cuff. Intraoperative findings revealed a thin epiretinal macular membrane (ERM) around the MH. Patient 2 was a 79-year-old male. Although the patient underwent pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) in both eyes, RS and a thin ERM in addition to SRD was observed in his left eye after surgery, and an MH developed during the clinical course. As in Patient 1, a convex surface was formed at the fluid cuff margin toward the vitreous cavity. Conclusions: Both patients had persistent DME, SRD, RS, and a thin ERM before the development of the MH. OCT revealed the formation of a convex surface at the MH margin toward the vitreous cavity, suggesting that the fragility of the layered structure of the retina combined with tangential retinal traction may have been involved in the atypical MH form.

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Full thickness macular hole following intravitreal ranibizumab injection for diabetic macular edema; a rare complication or coincidence?

Cited by 3 publications

References 4 publications

Full-Thickness Macular Hole Formation Following Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Full-Thickness Macular Hole Formation Following Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Ranibizumab

Two cases of diabetic macular edema complicated by an atypical macular hole

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