Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form

Darwish, Hany W.; Elzanfaly, Eman S.; Saad, Ahmed S.; Abdel-Aleem, Abdel-Aziz E

doi:10.1016/j.saa.2016.06.001

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…The measured spectrum of SAP is presented in Graphical abstract. Based on literature data the observed band at 240 nm has been assigned to both betamethasone sodium phosphate and betamethasone dipropionate [28,29,30]. No additional peaks in the wavelength range 200–900 nm at the used conditions were observed.…”

Section: Methodsmentioning

confidence: 76%

Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee

et al. 2019

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Implants are readily applied as a convenient method of therapy. There is great interest in the prolonged release of active substances from implants. The objective of this work was to evaluate the dissolution kinetics of steroidal anti-inflammatory preparation (SAP) released from novel implants, and to test the influence of the technology on SAP release kinetics. The proposed long-acting preparations may overcome difficulties resulting from repeated injections and often visits to ambulatory clinic, as the stabilizing function of the artificial ligament would be enriched with pharmacological activity. The potential advantages provided by the new coatings of knee implants include the continuous, sustained, and prolonged release of an active substance. The study was carried out using a modified United States Pharmacopoeia (USP) apparatus 4. The amount of SAP was measured spectroscopically. It was revealed that the transport of the drug was mainly a diffusion process. The drug release kinetics was analyzed using zero-, first-, and second-order kinetics as well as Korsmeyer-Peppas, Higuchi, and Hixon-Crowell models. The highest values of the release rate constants were k0 = (7.49 ± 0.05) × 10−5 mg × min−1, k1 = (6.93 ± 0.05) × 10−6 min−1, and k2 = (7.70 ± 0.05) × 10−7 mg−1 × min−1 as calculated according to zero-, first-, and second-order kinetics equations, respectively. The values of the rate constants obtained for the slowest process were k0 = (3.63 ± 0.06) × 10−5 mg × min−1, k1 = (2.50 ± 0.03) × 10−6 min−1, and k2 = (2.80 ± 0.03) × 10−7 mg−1 × min−1. They may suggest the possibility of sustained release of betamethasone from the system. Due to the statistical analysis, differences were observed between most of the studied implants. Incubation, temperature, time of stabilization of layers, and the method of SAP deposition on the matrix affected the drug release.

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Section: Methodsmentioning

confidence: 76%

Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee

et al. 2019

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“…The previous literature describes only one mathematical UV method [ 20 ] and five chemometric methods [ 37 ] for the analysis of pharmaceutical preparation containing only BET, CLO, and BEN without the presence of GEN, the USP describes an HPLC approach for the quantification of BET and CLO in cream preparations [ 38 ], another HPLC method [ 39 ] was reported for their quantification in a cream formulation.…”

Section: Introductionmentioning

confidence: 99%

A new selective colorimetric method coupled with a high-resolution UV method for the consecutive quantification of three drugs in semi-solid preparations

Sakur

Zakri

2022

Heliyon

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“…Chemometrics is the science that accords with extracting valuable information from the raw data. PCR and PLSR calibration methods are intended to be full spectrum computational procedures [8].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Acetylsalicylic Acid, Paracetamol and Ascorbic Acid by Chemometric Methods

Ertokuş¹,

Tuğrul²

2018

ChChT

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Acetylsalicylic acid, paracetamol, and ascorbic acid which are used for the pain reliever and fever reducer were analyzed without any prior reservation by means of spectrophotometry-chemometry. The experimental calibration matrix was designed by measuring the absorbance within the range of 200-400 nm for 19 samples of acetylsalicylic acid, paracetamol, and ascorbic acid. Absorbance and concentration values were analyzed using Minitab and other chemometric programs to calculate estimated concentrations by PCR and PLSR. In the first step the synthetic mixtures including acetylsalicylic acid, paracetamol, and ascorbic acid were prepared and absorbance values were obtained according to spectrophotometry. In the second step, amounts of acetylsalicylic acid, paracetamol, and ascorbic acid were calculated in effervescent tablet (Afebryl®). Standard deviations were accomplished. This study encouraged us to apply the developed methods for drug analysis. The methods presented in this paper are rapid and do not need any separation process or preliminary treatments for the analysis.

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Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form

Cited by 10 publications

References 21 publications

Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee

Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee

A new selective colorimetric method coupled with a high-resolution UV method for the consecutive quantification of three drugs in semi-solid preparations

Spectrophotometric Determination of Acetylsalicylic Acid, Paracetamol and Ascorbic Acid by Chemometric Methods

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