Full-field bulge test for planar anisotropic tissues: Part II – A thin shell method for determining material parameters and comparison of two distributed fiber modeling approaches

Tonge, Theresa K.; Voo, Liming; Nguyen, Thao D.

doi:10.1016/j.actbio.2012.11.034

Cited by 86 publications

(76 citation statements)

References 49 publications

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“…This is currently very challenging but there are very promising emerging approaches in skin research. For example, using digital image correlation techniques it is possible to obtain full (strain) field measurements (Tonge et al, 2013a;Tonge et al, 2013b). The modelling approach adopted here is a first step towards models to assess, understand and control the effects of the structural properties of skin in medicine, biology and industrial applications.…”

Section: Discussionmentioning

confidence: 99%

“…In a finite element modelling context, it implies that using a single set of mechanical properties for the stratum corneum would limit the domain of validity of the simulation results to specific conditions. A wide array of experimental and clinical measurement techniques are used to characterise particular aspects of skin biology and biophysics (Alexiades-Armenakas, 2007;Batisse et al, 2002;Bellemere et al, 2009;Delalleau et al, 2006;Diridollou et al, 2000;Gunner et al, 1979;Hendriks et al, 2006;Jor et al, 2013;Limbert and Simms, 2013;Tonge et al, 2013a;Tonge et al, 2013b;Wan Abas, 1994). Nevertheless, complementary approaches based on mathematical and computational modelling techniques offer promising avenues to further our understanding of the skin (Areias et al, 2003;Bischoff et al, 2000;Boissieux et al, 2000;Buganza Tepole and Kuhl, 2014;Cavicchi et al, 2009;Duan et al, 2000;Evans, 2009;Flynn and McCormack, 2008a, b;Flynn andMcCormack, 2009, 2010;Hendriks et al, 2006;Hendriks et al, 2003;Kuwazuru et al, 2008;Larrabee and Galt, 1986a, b;Larrabee and Sutton, 1986;Lévêque and Audoly, 2013;Tepole et al, 2014a;Tepole et al, 2014b;Tepole et al, 2011;Zöllner et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.www.elsevier.com/locate/jmbbm 1 A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. AbstractThe study of skin biophysics has largely been driven by consumer goods, biomedical and cosmetic industries which aim to design products that efficiently interact with the skin and/or modify its biophysical properties for health or cosmetic benefits. The skin is a hierarchical biological structure featuring several layers with their own distinct geometry and mechanical properties. Up to now, no computational models of the skin have simultaneously accounted for these geometrical and material characteristics to study their complex biomechanical interactions under particular macroscopic deformation modes.The goal of this study was, therefore, to develop a robust methodology combining histological sections of human skin, image-processing and finite element techniques to address fundamental questions about skin mechanics and, more particularly, about how macroscopic strains are transmitted and modulated through the epidermis and dermis. The work hypothesis was that, as skin deforms under macroscopic loads, the stratum corneum does not experience significant strains but rather folds/unfolds during skin extension/compression.A sample of fresh human mid-back skin was processed for wax histology. Sections were stained and photographed by optical microscopy. The multiple images were stitched together to produce a larger region of interest and segmented to extract the geometry of the stratum corneum, viable epidermis and dermis. From the segmented structures a 2D finite element mesh of the skin composite model was created and geometrically non-linear plane-strain finite element analyses were conducted to study the sensitivity of the model to variations in mechanical properties.The hybrid experimental-computational methodology has offered valuable insights into the simulated mechanics of the skin, and that of the stratum corneum in particular, by providing qualitative and quantitative information on strain magnitude and distribution. Through a complex non-linear interplay, the geometry and mechanical characteristics of the skin layers (and their relative balance), play a critical role in conditioning the skin mechanical response to macroscopic in-plane compression and extension. Topographical features of the skin surface such as furrows were shown to act as an efficient means to deflec...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

View full text Add to dashboard Cite

show abstract

“…While the matrix is expected to be much softer than the collagen fibers, finding μ 1 = 0 is unrealistic and suggests that the elastin fibers and ground substance do not contribute to the overall mechanical response. Other investigators have corrected this problem by assigning a relationship between μ 1 and μ 2 [13] or by separately fitting the low strain region of the stressstrain curve using only the contribution of the matrix to the stress [32]. Since fixing the relationship between μ 1 and μ 2 would make it impossible to examine the spatial patterns in μ 1 or μ 2 the latter solution would be more suited to our approach.…”

Section: Discussionmentioning

confidence: 99%

“…Since fixing the relationship between μ 1 and μ 2 would make it impossible to examine the spatial patterns in μ 1 or μ 2 the latter solution would be more suited to our approach. For a small data set, the transition between low strain and high strain is identified by manually inspecting the curves and selecting a window that is appropriate for the data collected [32]. However, in our case, due to the abundance of data and the variety of loading regimes (Fig.…”

Section: Discussionmentioning

confidence: 99%

Local mechanical properties of human ascending thoracic aneurysms

Davis

Luo

Avril

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Ascending thoracic aortic aneurysms (ATAAs) are focal, asymmetric dilatations of the aortic wall which are prone to rupture. To identify potential rupture locations in advance, it is necessary to consider the inhomogeneity of the ATAA at the millimeter scale. Towards this end, we have developed a combined experimental and computational approach using bulge inflation tests, digital image correlation (DIC), and an inverse membrane approach to characterize the pointwise stress, strain, and hyperelastic properties of the ATAA. Using this approach, the pointwise hyperelastic material properties were identified on 10 human ATAA samples collected from patients undergoing elective surgery to replace their ATAAs with a graft. Our method was able to capture the varying levels of heterogeneity in the ATAA from regional to local. It was shown for the first time that the material properties in the ATAA are unmistakably heterogeneous at length scales between 1 mm and 1 cm, which are length scales where vascular tissue is typically treated as homogeneous. The distributions of the material properties for each patient were also examined to study the inter-and intra-patient variability. Large inter-subject variability was observed in the elastic properties.

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“…Finally, biological planar tissues are not always thin enough to be considered as membranes, leading to bending moments and out-of-plane stresses. Several studies have successfully incorporated tissue nonlinearity and anisotropy in parameter estimation schemes of bulge tests [18,19,20,21,22,23]. Yet, no study has, to the best of the authors' knowledge, addressed the effects of tissue thickness, nor has tissue prestretch been accounted for.…”

Section: Introductionmentioning

confidence: 99%

Nondestructive mechanical characterization of developing biological tissues using inflation testing

Oomen

Kelle

Oomens

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Full-field bulge test for planar anisotropic tissues: Part II – A thin shell method for determining material parameters and comparison of two distributed fiber modeling approaches

Cited by 86 publications

References 49 publications

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Local mechanical properties of human ascending thoracic aneurysms

Nondestructive mechanical characterization of developing biological tissues using inflation testing

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