Full cDNA of a novel HLA‐B39 subtype, B*39061

Zhao, Wei; Fernandez-Vina, M; Lázaro, A. M.; Araujo, H. Andres; Miller, Sharon A.; Šťastný, Peter

doi:10.1111/j.1399-0039.1996.tb02582.x

Cited by 7 publications

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“…Serological data ( 10, 12–17) and more recently, DNA‐sequence data ( 11, 18–22) suggest that few allelic lineages are present in the Amerindian HLA gene pools. In spite of this, many novel HLA‐class I alleles have been identified in indigenous tribes of North and South America ( 18–33). Some investigators have suggested that the HLA‐B locus is evolving more rapidly than the other loci in South American Indian tribes ( 8, 18, 21, 22).…”

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Novel HLA‐A and HLA‐B alleles in South American Indians

et al. 1999

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The human leukocyte antigen (HLA) complex includes the most polymorphic genes in humans. More than 600 allelic variants have been described in different populations. The HLA-B locus has contributed the largest number of alleles. Although Native American populations display a restricted number of HLA-alleles, many novel HLA class I alleles have been identified in indigenous communities of Central and South America. We have studied 248 unrelated individuals from three tribes of North-East Argentina and one from South-West Brazil, as well as 80 related individuals from the Brazilian tribe. In the course of this work, we found 8 new B-locus alleles and 2 novel A-locus alleles in these populations. Here we report the nucleotide sequences of A*0219, A*0222, B*3519, B*3520, B*3521, B*3912, B*4009 and B*4803 and we show their relationship with similar alleles. The new alleles B*35092 and B*3518 have been described by us in a previous paper. The possible mechanisms that may have produced these alleles over evolutionary time are discussed.

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confidence: 99%