Fuel oxidation under the control of mitochondrial shape and dynamics

Abstract

How mitochondrial shape and substrate‐specific metabolism are related has been a difficult question to address. Here, new work by Ngo et al (2023) reports that mitochondrial shape—long versus fragmented—determines the activity of β‐oxidation of long‐chain fatty acids, supporting a novel role for mitochondrial fission products as β‐oxidation hubs.